Translational Defects in a Mutant Deficient in YajL, the Bacterial Homolog of the Parkinsonism-Associated Protein DJ-1

ABSTRACT We report here that YajL is associated with ribosomes and interacts with many ribosomal proteins and that a yajL mutant of Escherichia coli displays decreased translation accuracy, as well as increased dissociation of 70S ribosomes into 50S and 30S subunits after oxidative stress.

[1]  P. Bouloc,et al.  Protein Aggregation in a Mutant Deficient in YajL, the Bacterial Homolog of the Parkinsonism-associated Protein DJ-1 , 2010, The Journal of Biological Chemistry.

[2]  J. Rousset,et al.  Nucleotide modifications in three functionally important regions of the Saccharomyces cerevisiae ribosome affect translation accuracy , 2009, Nucleic acids research.

[3]  A. Al Refaii,et al.  Ribosome biogenesis is temperature‐dependent and delayed in Escherichia coli lacking the chaperones DnaK or DnaJ † , 2009, Molecular microbiology.

[4]  Ming Zhan,et al.  RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways , 2008, Proceedings of the National Academy of Sciences.

[5]  C. Grant,et al.  The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. , 2008, The Biochemical journal.

[6]  T. Caldas,et al.  YhbO Protects Cells against Multiple Stresses , 2007, Journal of bacteriology.

[7]  T. Dawson,et al.  DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase , 2007, Proceedings of the National Academy of Sciences.

[8]  M. Kaczanowska,et al.  Ribosome Biogenesis and the Translation Process in Escherichia coli , 2007, Microbiology and Molecular Biology Reviews.

[9]  Roxana Nechifor,et al.  Crosslinking of translation factor EF-G to proteins of the bacterial ribosome before and after translocation. , 2007, Journal of molecular biology.

[10]  Jing Zhang,et al.  Identification of Novel Proteins Associated with Both α-Synuclein and DJ-1*S , 2007, Molecular & Cellular Proteomics.

[11]  D. Andersson,et al.  Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19. , 2007, Journal of molecular biology.

[12]  G. Culver,et al.  A novel single amino acid change in small subunit ribosomal protein S5 has profound effects on translational fidelity. , 2006, RNA.

[13]  T. Mak,et al.  DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 , 2006, Proceedings of the National Academy of Sciences.

[14]  V. Bolanos-Garcia,et al.  Structural analysis and classification of native proteins from E. coli commonly co-purified by immobilised metal affinity chromatography. , 2006, Biochimica et biophysica acta.

[15]  Koichi Ito,et al.  Ribosomal protein L11 mutations in two functional domains equally affect release factors 1 and 2 activity , 2006, Molecular microbiology.

[16]  Mark A. Wilson,et al.  The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein , 2006 .

[17]  H. Mori,et al.  Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection , 2006, Molecular systems biology.

[18]  M. Ehrenberg,et al.  The Role of Ribosomal Protein L11 in Class I Release Factor-mediated Translation Termination and Translational Accuracy* , 2006, Journal of Biological Chemistry.

[19]  Gregory A Petsko,et al.  The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. , 2005, Journal of molecular biology.

[20]  Xin Zhao,et al.  Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Maki Maeda,et al.  The GTP binding protein Obg homolog ObgE is involved in ribosome maturation , 2005, Genes to cells : devoted to molecular & cellular mechanisms.

[22]  M. Widerak,et al.  U2552 methylation at the ribosomal A-site is a negative modulator of translational accuracy. , 2005, Gene.

[23]  H. Mori,et al.  Peptidase Activity of the Escherichia coli Hsp31 Chaperone* , 2004, Journal of Biological Chemistry.

[24]  A. Abeliovich,et al.  DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation , 2004, PLoS biology.

[25]  David W. Miller,et al.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Dreyfus,et al.  CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit. , 2004, Nucleic acids research.

[27]  G. Petsko,et al.  The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[28]  V. Ramakrishnan,et al.  Insights into the decoding mechanism from recent ribosome structures. , 2003, Trends in biochemical sciences.

[29]  Konstantin Korotkov,et al.  The 1.6-Å crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  F. Baneyx,et al.  Hsp31, the Escherichia coli yedU Gene Product, Is a Molecular Chaperone Whose Activity Is Inhibited by ATP at High Temperatures* , 2002, The Journal of Biological Chemistry.

[31]  N. Ban,et al.  L23 protein functions as a chaperone docking site on the ribosome , 2002, Nature.

[32]  U. Jakob,et al.  Overexpression of Two Different GTPases Rescues a Null Mutation in a Heat-Induced rRNA Methyltransferase , 2002, Journal of bacteriology.

[33]  M. Rodnina,et al.  Ribosome fidelity: tRNA discrimination, proofreading and induced fit. , 2001, Trends in biochemical sciences.

[34]  E. Binet,et al.  Translational defects of Escherichia coli mutants deficient in the Um(2552) 23S ribosomal RNA methyltransferase RrmJ/FTSJ. , 2000, Biochemical and biophysical research communications.

[35]  J. F. Atkins,et al.  A three-way junction and constituent stem-loops as the stimulator for programmed -1 frameshifting in bacterial insertion sequence IS911. , 1999, Journal of molecular biology.

[36]  B. Golden,et al.  Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance. , 1998, Journal of molecular biology.

[37]  Claes Gustafsson,et al.  Identification of the rrmA Gene Encoding the 23S rRNA m1G745 Methyltransferase in Escherichia coli and Characterization of an m1G745-Deficient Mutant , 1998, Journal of bacteriology.

[38]  R. Wickner,et al.  5 S rRNA is involved in fidelity of translational reading frame. , 1995, Genetics.

[39]  A. E. Dahlberg,et al.  Mutations at U2555, a tRNA-protected base in 23S rRNA, affect translational fidelity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. O'Connor,et al.  A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA. , 1992, Nucleic acids research.

[41]  T. Nagatsu.  [Biochemistry of Parkinson's disease]. , 1988, Seikagaku. The Journal of Japanese Biochemical Society.

[42]  D. Dunn,et al.  Reading frame switch caused by base‐pair formation between the 3′ end of 16S rRNA and the mRNA during elongation of protein synthesis in Escherichia coli. , 1988, The EMBO journal.

[43]  D. Primerano,et al.  Role of Acetohydroxy Acid Isomeroreductase in Biosynthesis of Pantothenic Acid in Salmonella typhimurium , 1983, Journal of bacteriology.

[44]  W. Held,et al.  Reconstitution of Escherichia coli 30 S ribosomal subunits from purified molecular components. , 1973, The Journal of biological chemistry.

[45]  D. Mash,et al.  Multiregional gene expression profiling identifies MRPS6 as a possible candidate gene for Parkinson's disease. , 2006, Gene expression.

[46]  G. Petsko,et al.  The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. , 2006, Journal of molecular biology.

[47]  Claire Bertrand,et al.  Influence of the stacking potential of the base 3' of tandem shift codons on -1 ribosomal frameshifting used for gene expression. , 2002, RNA.

[48]  H. Noller,et al.  Ribosomes and translation. , 1997, Annual review of biochemistry.