Inhibition of LRRK2 kinase activity stimulates macroautophagy
暂无分享,去创建一个
P. Giunti | A. Mamais | C. Manzoni | P. Lewis | S. Tooze | M. Soutar | R. Bandopadhyay | H. Plun-Favreau | S. Dihanich | R. Abeti
[1] A. Mamais,et al. Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations , 2012, PloS one.
[2] C. Manzoni. LRRK2 and autophagy: a common pathway for disease. , 2012, Biochemical Society transactions.
[3] E. Greggio. Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease. , 2012, Biochemical Society transactions.
[4] N. Gray,et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. , 2012, Bioorganic & medicinal chemistry letters.
[5] C. Thompson,et al. Therapeutic targets in cancer cell metabolism and autophagy , 2012, Nature Biotechnology.
[6] M. Memo,et al. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease , 2012, EMBO molecular medicine.
[7] Eun-Young Kim,et al. Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia , 2012, PloS one.
[8] D. Jewell,et al. Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease , 2012, Inflammatory bowel diseases.
[9] M. Cookson,et al. Parkinson disease, cancer, and LRRK2 , 2012, Neurology.
[10] M. Cookson,et al. Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? , 2012, BMC Medicine.
[11] D. Standaert,et al. LRRK2 Inhibition Attenuates Microglial Inflammatory Responses , 2012, The Journal of Neuroscience.
[12] C. Manzoni,et al. LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? , 2012, Science Signaling.
[13] H. Cai,et al. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway , 2012, Molecular Neurodegeneration.
[14] S. Bruley des Varannes,et al. Parkinson disease , 2011, Neurology.
[15] G. Drewes,et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. , 2011, ACS chemical biology.
[16] G. Churchill,et al. Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP , 2011, Human molecular genetics.
[17] J. Ioannidis,et al. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study , 2011, The Lancet Neurology.
[18] A. West,et al. Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. , 2011, Journal of molecular biology.
[19] M. Cookson,et al. LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding , 2011, PloS one.
[20] Carolinne de Sales Marques,et al. Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome. , 2011, Future microbiology.
[21] David S. Park,et al. Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures , 2011, Journal of Neural Transmission.
[22] Y. Liu,et al. Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2 , 2011, PloS one.
[23] D. Rubinsztein,et al. Protein misfolding disorders and macroautophagy , 2011, Current opinion in cell biology.
[24] N. Gray,et al. Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2 , 2011, Nature chemical biology.
[25] Mohamad Saad,et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies , 2011, The Lancet.
[26] N. Mizushima,et al. p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding , 2011, The Journal of cell biology.
[27] V. Baekelandt,et al. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant , 2011, Journal of neurochemistry.
[28] Mark R. Cookson,et al. The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease , 2010, Nature Reviews Neuroscience.
[29] Mark J Daly,et al. LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens , 2010, The Journal of Immunology.
[30] D. Rigden,et al. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation , 2010, Autophagy.
[31] R. J. Kelleher,et al. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice , 2010, Proceedings of the National Academy of Sciences.
[32] A. Gitler,et al. GTPase Activity Plays a Key Role in the Pathobiology of LRRK2 , 2010, PLoS genetics.
[33] M. Cookson,et al. The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation , 2010, PloS one.
[34] D. Klionsky,et al. Regulation mechanisms and signaling pathways of autophagy. , 2009, Annual review of genetics.
[35] Richard Wade-Martins,et al. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. , 2009, Human molecular genetics.
[36] A. Wittinghofer,et al. It takes two to tango: regulation of G proteins by dimerization , 2009, Nature Reviews Molecular Cell Biology.
[37] P. Lewis. The function of ROCO proteins in health and disease , 2009, Biology of the cell.
[38] M. Cookson,et al. Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions , 2009, ASN neuro.
[39] M. Duchen,et al. CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia , 2008, The Journal of Neuroscience.
[40] R. Takahashi,et al. Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila , 2008, The EMBO journal.
[41] Daniel J Klionsky,et al. The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy , 2008, EMBO reports.
[42] Judy H. Cho,et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease , 2008, Nature Genetics.
[43] Guillermo Repetto,et al. Neutral red uptake assay for the estimation of cell viability/cytotoxicity , 2008, Nature Protocols.
[44] Ivan Dikic,et al. Atypical ubiquitin chains: new molecular signals , 2008, EMBO reports.
[45] C. Chu,et al. Role of autophagy in G2019S‐LRRK2‐associated neurite shortening in differentiated SH‐SY5Y cells , 2008, Journal of neurochemistry.
[46] C. Olanow,et al. Leucine‐rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson’s disease R1441C/G mutants , 2007, Journal of neurochemistry.
[47] M. Cookson,et al. The R1441C mutation of LRRK2 disrupts GTP hydrolysis. , 2007, Biochemical and biophysical research communications.
[48] C. Ross,et al. Kinase activity of mutant LRRK2 mediates neuronal toxicity , 2006, Nature Neuroscience.
[49] David W. Miller,et al. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin , 2006, Neurobiology of Disease.
[50] C. Ross,et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[51] G. Schackert,et al. Identification of Uncommon Chromosomal Aberrations in the Neuroglioma Cell Line H4 by Spectral Karyotyping , 2001, Journal of Neuro-Oncology.
[52] J. M. Bravo-San Pedro,et al. The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway , 2012, Cellular and Molecular Life Sciences.
[53] M. Netea,et al. Genomewide association study of leprosy. , 2010, The New England journal of medicine.
[54] R. Huebner,et al. Propagation of human tumors in antithymocyte serum-treated mice. , 1974, Journal of the National Cancer Institute.