The effects of connexin phosphorylation on gap junctional communication.

[1]  A. Lau,et al.  Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. , 1993, Molecular biology of the cell.

[2]  D. Laird,et al.  Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells , 1995, The Journal of cell biology.

[3]  T. Shimazu,et al.  Phosphorylation of the 27-kDa gap junction protein by protein kinase C in vitro and in rat hepatocytes. , 1989, Journal of biochemistry.

[4]  B. Giepmans,et al.  Acute loss of Cell–Cell Communication Caused by G Protein–coupled Receptors: A Critical Role for c-Src , 1998, The Journal of cell biology.

[5]  P. Lampe,et al.  Analysis of connexin phosphorylation sites. , 2000, Methods.

[6]  H. Jongsma,et al.  TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels. , 1995, Experimental cell research.

[7]  T. Takeya,et al.  Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells , 2002, FEBS letters.

[8]  J. Reynhout,et al.  Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP , 2001, The Journal of cell biology.

[9]  T. W. White.  Unique and Redundant Connexin Contributions to Lens Development , 2002, Science.

[10]  J. Burt,et al.  Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.

[11]  S. Taffet,et al.  A 17mer peptide interferes with acidification-induced uncoupling of connexin43. , 1998, Circulation research.

[12]  B. Nicholson,et al.  Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels , 1999, The Journal of cell biology.

[13]  E E Daniel,et al.  Gap junctions: their presence and necessity in myometrium during parturition. , 1977, Science.

[14]  P. Lampe,et al.  The gap-junction protein connexin 56 is phosphorylated in the intracellular loop and the carboxy-terminal region. , 1997, European journal of biochemistry.

[15]  P. Lampe,et al.  Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation , 2003, Journal of Cell Science.

[16]  A. Nairn,et al.  Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. , 1997, Journal of molecular and cellular cardiology.

[17]  A. Lau,et al.  Tyrosine Phosphorylation of Connexin 43 by v-Src Is Mediated by SH2 and SH3 Domain Interactions* , 1997, The Journal of Biological Chemistry.

[18]  A. Jagdale,et al.  Mitogen‐activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet‐derived growth factor and tetradecanoylphorbol acetate , 1999, Journal of cellular physiology.

[19]  G. Sandusky,et al.  Protein Kinase C- α and - ϵ Modulate Connexin-43 Phosphorylation in Human Heart , 2001 .

[20]  S. Mollerup,et al.  Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells. , 1998, Cell adhesion and communication.

[21]  R. Ruch,et al.  Gap‐junction disassembly and connexin 43 dephosphorylation induced by 18β‐glycyrrhetinic acid , 1996, Molecular carcinogenesis.

[22]  C. Zuppan,et al.  Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality. , 1995, The New England journal of medicine.

[23]  R. Weingart,et al.  Effects of phorbol ester on gap junctions of neonatal rat heart cells , 1993, Pflügers Archiv.

[24]  E. Hertzberg,et al.  Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+. , 1992, European journal of cell biology.

[25]  T. Oite,et al.  PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells. , 2000, Kidney international.

[26]  T. Husøy,et al.  Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. , 2001, Experimental cell research.

[27]  A. Boynton,et al.  Platelet‐derived growth factor‐induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen‐activated protein kinase , 1998, Journal of cellular physiology.

[28]  H. Piwnica-Worms,et al.  Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication. , 1990, Cell regulation.

[29]  D. Goodenough,et al.  Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation , 1990, The Journal of Membrane Biology.

[30]  A. Villalobo,et al.  The epidermal growth factor receptor tyrosine kinase phosphorylates connexin32 , 1998, Molecular and Cellular Biochemistry.

[31]  K. Willecke,et al.  Unique and shared functions of different connexins in mice , 2000, Current Biology.

[32]  G. Sandusky,et al.  Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart. , 2001, Journal of molecular and cellular cardiology.

[33]  T. Husøy,et al.  Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase C beta I and mu. , 2001, Carcinogenesis.

[34]  A. Boynton,et al.  Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet‐derived growth factor in T51B rat liver epithelial cells expressing platelet‐derived growth factor receptor , 1998, Journal of cellular physiology.

[35]  J. Hervé,et al.  Endogenous protein phosphatase 1 runs down gap junctional communication of rat ventricular myocytes. , 2001, American journal of physiology. Cell physiology.

[36]  Andrew N. Carr,et al.  Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. , 2002, Cardiovascular research.

[37]  B. Giepmans,et al.  Interaction of c-Src with Gap Junction Protein Connexin-43 , 2001, The Journal of Biological Chemistry.

[38]  L. Klotz,et al.  2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. , 2002, Cancer research.

[39]  M. Chanson,et al.  cAMP promotes gap junctional coupling in T84 cells. , 1996, The American journal of physiology.

[40]  A. Lau,et al.  In vivo association of pp60v‐src and the gap‐junction protein connexin 43 in v‐src–transformed fibroblasts , 1999, Molecular carcinogenesis.

[41]  E. Rivedal,et al.  Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells. , 2001, Carcinogenesis.

[42]  J. Nagy,et al.  Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition , 2000, The European journal of neuroscience.

[43]  V. Cruciani,et al.  Phosphatases involved in modulation of gap junctional intercellular communication and dephosphorylation of connexin43 in hamster fibroblasts: 2B or not 2B? , 1999, Experimental cell research.

[44]  H. Jongsma,et al.  Human connexin40 gap junction channels are modulated by cAMP. , 2000, Cardiovascular research.

[45]  R. Burghardt,et al.  Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of connexin43 , 1995, The Journal of Membrane Biology.

[46]  A. Lau,et al.  pp60src -mediated Phosphorylation of Connexin 43, a Gap Junction Protein (*) , 1995, The Journal of Biological Chemistry.

[47]  T. Husøy,et al.  Phosphatase inhibitors, gap junctional intercellular communication and [125I]-EGF binding in hamster fibroblasts. , 1993, Carcinogenesis.

[48]  G. Morley,et al.  Intramolecular interactions mediate pH regulation of connexin43 channels. , 1996, Biophysical journal.

[49]  J. Loturco,et al.  Differential regulation of connexin 26 and 43 in murine neocortical precursors. , 1999, Cerebral cortex.

[50]  C. Louis,et al.  Functional Effects of Casein Kinase I-Catalyzed Phosphorylation on Lens Cell-to-Cell Coupling , 2001, The Journal of Membrane Biology.

[51]  D. Walsh,et al.  In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C , 1993, Molecular and Cellular Biochemistry.

[52]  N. Gilula,et al.  The Gap Junction Communication Channel , 1996, Cell.

[53]  J. Revel,et al.  Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. , 1991, The Biochemical journal.

[54]  J. Saffitz,et al.  Expression of multiple connexins in cultured neonatal rat ventricular myocytes. , 1995, Circulation research.

[55]  K. Ballmer-Hofer,et al.  VEGF transiently disrupts gap junctional communication in endothelial cells. , 2001, Journal of cell science.

[56]  J. Reynhout,et al.  An activator of protein kinase C inhibits gap junction communication between cultured bovine lens cells. , 1992, Experimental cell research.

[57]  J. Revel,et al.  Identification of intermediate forms of connexin43 in rat cardiac myocytes , 1993 .

[58]  D. Kiang,et al.  Cyclic AMP modifies the cellular distribution of connexin43 and induces a persistent increase in the junctional permeability of mouse mammary tumor cells. , 1995, Journal of cell science.

[59]  A. Moreno,et al.  Gap Junctions between Cells Expressing Connexin 43 or 32 Show Inverse Permselectivity to Adenosine and ATP* , 2002, The Journal of Biological Chemistry.

[60]  L. Wagner,et al.  Effect of protein kinase Cgamma on gap junction disassembly in lens epithelial cells and retinal cells in culture. , 2002, Molecular vision.

[61]  D. Paul,et al.  Connexins, connexons, and intercellular communication. , 1996, Annual review of biochemistry.

[62]  M. Mercola,et al.  Gap junctions are involved in the early generation of left-right asymmetry. , 1998, Developmental biology.

[63]  J. Trosko,et al.  Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation , 2001, Journal of cellular biochemistry.

[64]  W. Jiang,et al.  Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[65]  P. Greengard,et al.  Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. , 1990, European journal of biochemistry.

[66]  H. Huynh,et al.  Deficiency of connexin43 gap junctions is an independent marker for breast tumors. , 1999, Cancer research.

[67]  K. Willecke,et al.  Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes , 1989, The Journal of cell biology.

[68]  David L. Paul,et al.  Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block , 1998, Current Biology.

[69]  B. Rose,et al.  Transcription of the gene for the gap junctional protein connexin43 and expression of functional cell-to-cell channels are regulated by cAMP. , 1992, Molecular biology of the cell.

[70]  J. Degen,et al.  Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome , 2002, Biological chemistry.

[71]  P. Meda,et al.  Cell uncoupling and protein kinase C: correlation in a cell line but not in a differentiated tissue. , 1988, The American journal of physiology.

[72]  R. Lin,et al.  v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication , 2001, The Journal of cell biology.

[73]  D. Kelsell,et al.  Connexin 26 mutations in hereditary non-syndromic sensorineural deafness , 1997, nature.

[74]  B. Doble,et al.  The ε Subtype of Protein Kinase C Is Required for Cardiomyocyte Connexin-43 Phosphorylation , 2000 .

[75]  P. Lampe,et al.  Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication , 2000, The Journal of cell biology.

[76]  A. Kazlauskas,et al.  Disruption of Gap Junctional Communication by the Platelet-derived Growth Factor Is Mediated via Multiple Signaling Pathways* , 1999, The Journal of Biological Chemistry.

[77]  K. Willecke,et al.  Transplacental Uptake of Glucose Is Decreased in Embryonic Lethal Connexin26-deficient Mice , 1998, The Journal of cell biology.

[78]  P. Lampe,et al.  Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein (*) , 1996, The Journal of Biological Chemistry.

[79]  C. Joe,et al.  PKC phosphorylation disrupts gap junctional communication at G0/S phase in clone 9 cells , 1997, Molecular and Cellular Biochemistry.

[80]  D. Le Paslier,et al.  Lack of evidence for connexin 43 gene mutations in human autosomal recessive lateralization defects. , 1997, Journal of molecular and cellular cardiology.

[81]  P. Lampe,et al.  Regulation of gap junctions by phosphorylation of connexins. , 2000, Archives of biochemistry and biophysics.

[82]  S. Taffet,et al.  A particle-receptor model for the insulin-induced closure of connexin43 channels. , 1998, Circulation research.

[83]  H. Jongsma,et al.  Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation. , 2000, Cardiovascular research.

[84]  M. Hori,et al.  c-Src Regulates the Interaction between Connexin-43 and ZO-1 in Cardiac Myocytes* , 2001, The Journal of Biological Chemistry.

[85]  J. Saffitz,et al.  Rapid turnover of connexin43 in the adult rat heart. , 1998, Circulation research.

[86]  D. Goodenough,et al.  Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques , 1991, The Journal of cell biology.

[87]  W. Loewenstein,et al.  Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[88]  G M Edelman,et al.  Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines , 1990, The Journal of cell biology.

[89]  L. Leinwand,et al.  Functional analysis of human cardiac gap junction channel mutants. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[90]  P. Lampe,et al.  Casein Kinase 1 Regulates Connexin-43 Gap Junction Assembly* , 2002, The Journal of Biological Chemistry.

[91]  D C Spray,et al.  Structure-activity relations of the cardiac gap junction channel. , 1990, The American journal of physiology.

[92]  A. Lau,et al.  p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src. , 1994, Oncogene.

[93]  K. Fischbeck,et al.  Connexin mutations in X-linked Charcot-Marie-Tooth disease. , 1993, Science.

[94]  A. Boynton,et al.  Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. , 1992, Molecular biology of the cell.

[95]  G. Dotto,et al.  The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins , 1991 .

[96]  P. Lampe,et al.  Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking. , 2000, Journal of cell science.

[97]  E. Beyer,et al.  PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication. , 2000, Investigative ophthalmology & visual science.

[98]  V. Hu,et al.  A Mitosis-specific Phosphorylation of the Gap Junction Protein Connexin43 in Human Vascular Cells: Biochemical Characterization and Localization , 1997, The Journal of cell biology.

[99]  V. Lee,et al.  Epidermal Growth Factor Enhances Expression of Connexin 43 Protein in Cultured Porcine Preantral Follicles1 , 2002, Biology of reproduction.

[100]  D. S. Crow,et al.  Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts , 1990, Molecular and cellular biology.

[101]  A. Nairn,et al.  Rat connexin43: regulation by phosphorylation in heart , 1993 .

[102]  B L Langille,et al.  Cardiac malformation in neonatal mice lacking connexin43. , 1995, Science.

[103]  D. Lidington,et al.  Lipopolysaccharide‐induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin 43 , 2002, Journal of cellular physiology.

[104]  S. Lye,et al.  Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio. , 1993, Endocrinology.

[105]  J. Burt,et al.  Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication. , 2003, American journal of physiology. Cell physiology.

[106]  K. Willecke,et al.  Phosphorylated Carboxy Terminal Serine Residues Stabilize the Mouse Gap Junction Protein Connexin45 Against Degradation , 1998, The Journal of Membrane Biology.

[107]  A. Buchmann,et al.  The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains. , 1999, Carcinogenesis.

[108]  P. Lampe.  Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly , 1994, The Journal of cell biology.

[109]  M. Shah,et al.  The connexin43 gap junction protein is phosphorylated by protein kinase A and protein kinase C: In vivo and in vitro studies , 2002, Molecular and Cellular Biochemistry.

[110]  Kurata We,et al.  p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src. , 1994 .

[111]  M Delmar,et al.  PH regulation of connexin43: molecular analysis of the gating particle. , 1996, Biophysical journal.

[112]  J. Sáez,et al.  Regulation of gap junctions by protein phosphorylation. , 1998, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[113]  G. Dotto,et al.  The Tumor Promoter 12-0-Tetradecanoylphorbol-13-Acetate and the ras Oncogene Modulate Expression and Phosphorylation of Gap Junction Proteins , 2022 .

[114]  P. Greengard,et al.  cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[115]  Jean X. Jiang,et al.  The Development-associated Cleavage of Lens Connexin 45.6 by Caspase-3-like Protease Is Regulated by Casein Kinase II-mediated Phosphorylation* , 2001, The Journal of Biological Chemistry.

[116]  A. Mikhailov,et al.  Dynamics of gap junctions observed in living cells with connexin43-GFP chimeric protein. , 1999, European journal of cell biology.

[117]  W. Fletcher,et al.  The hormone-induced regulation of contact-dependent cell-cell communication by phosphorylation. , 1990, Endocrine reviews.

[118]  P. Lampe,et al.  Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase. , 1998, Journal of cell science.

[119]  B. Doble,et al.  The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. , 2000, Circulation research.

[120]  C. Joe,et al.  Gating Connexin 43 Channels Reconstituted in Lipid Vesicles by Mitogen-activated Protein Kinase Phosphorylation* , 1999, The Journal of Biological Chemistry.