论文信息 - Response to Letter Regarding Article, “The Inflammatory Hypothesis: Any Progress in Risk Stratification and Therapeutic Targets?”

Response to Letter Regarding Article, “The Inflammatory Hypothesis: Any Progress in Risk Stratification and Therapeutic Targets?”

We thank Drs Ridker and Everett for their interest in our work,1 and we commend Ridker’s pioneering work describing an association between C-reactive protein (CRP) and the risk of myocardial infarction or stroke. Subsequent studies have both confirmed and refuted these original observations. The former studies “controlled” or “adjusted” for fewer other risk factors; when they did so, they dichotomized variables (a weaker approach) rather than using them as continuous variables. By contrast, the latter studies have incorporated adjustments for other markers (especially of abdominal obesity, because visceral fat …

S. Yusuf | S. Blankenberg

[1] S. Yusuf,et al. The Inflammatory Hypothesis: Any Progress in Risk Stratification and Therapeutic Targets? , 2006, Circulation.

[2] A. Hofman,et al. High Serum C-Reactive Protein Level Is Not an Independent Predictor for Stroke: The Rotterdam Study , 2006, Circulation.

[3] Juan P Casas,et al. Insight into the nature of the CRP-coronary event association using Mendelian randomization. , 2006, International journal of epidemiology.

[4] S. Yusuf,et al. Comparative Impact of Multiple Biomarkers and N-Terminal Pro-Brain Natriuretic Peptide in the Context of Conventional Risk Factors for the Prediction of Recurrent Cardiovascular Events in the Heart Outcomes Prevention Evaluation (HOPE) Study , 2006, Circulation.

[5] Lu Tian,et al. Narrative Review: Assessment of C-Reactive Protein in Risk Prediction for Cardiovascular Disease , 2006, Annals of Internal Medicine.

[6] Vilmundur Gudnason,et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. , 2004, The New England journal of medicine.