Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction

Visual Abstract

[1]  J. Cohn,et al.  Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. , 2000, Journal of the American College of Cardiology.

[2]  E. Marbán,et al.  Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology. , 2016, Annual review of physiology.

[3]  E. Marbán,et al.  Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens , 2007, Circulation.

[4]  V. Wedeen,et al.  Diffusion MR tractography of the heart , 2009, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[5]  Han Wen,et al.  In vivo study of microcirculation in canine myocardium using the IVIM method † , 2003, Magnetic resonance in medicine.

[6]  G. Dai,et al.  Diffusion MRI Tractography of the Developing Human Fetal Heart , 2013, PloS one.

[7]  E. Marbán,et al.  Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction , 2016, European heart journal.

[8]  I. Efimov,et al.  Resolution of Established Cardiac Hypertrophy and Fibrosis and Prevention of Systolic Dysfunction in a Transgenic Rabbit Model of Human Cardiomyopathy Through Thiol-Sensitive Mechanisms , 2009, Circulation.

[9]  Holden H. Wu,et al.  Convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion–compensated diffusion‐weighted MRI , 2017, Magnetic resonance in medicine.

[10]  E. Marbán,et al.  Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy , 2014, PloS one.

[11]  M. Zile,et al.  Cardiosphere-Derived Cells Reverse Heart Failure With Preserved Ejection Fraction in Rats by Decreasing Fibrosis and Inflammation , 2016, JACC. Basic to translational science.

[12]  Sebastian Kozerke,et al.  Microstructural Impact of Ischemia and Bone Marrow–Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo , 2014, Circulation.

[13]  E. Marbán,et al.  In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance , 2014, Journal of Cardiovascular Magnetic Resonance.

[14]  Udo Hoffmann,et al.  Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation , 2012, Journal of Cardiovascular Magnetic Resonance.

[15]  Ahmad Raza Khan,et al.  3D structure tensor analysis of light microscopy data for validating diffusion MRI , 2015, NeuroImage.

[16]  Tetsuo Sasano,et al.  Engraftment, Differentiation, and Functional Benefits of Autologous Cardiosphere-Derived Cells in Porcine Ischemic Cardiomyopathy , 2009, Circulation.

[17]  Edward W Hsu,et al.  Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. , 2005, The Journal of thoracic and cardiovascular surgery.

[18]  E. Marbán,et al.  Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction , 2013, Circulation.

[19]  Tevfik F Ismail,et al.  In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy , 2014, Journal of Cardiovascular Magnetic Resonance.

[20]  M. Budde,et al.  Quantification of anisotropy and fiber orientation in human brain histological sections , 2012, Front. Integr. Neurosci..

[21]  Gregory M. Fomovsky,et al.  Regional mechanics determine collagen fiber structure in healing myocardial infarcts. , 2012, Journal of molecular and cellular cardiology.

[22]  V. Wedeen,et al.  Diffusion Tensor Magnetic Resonance Imaging Mapping the Fiber Architecture Remodeling in Human Myocardium After Infarction: Correlation With Viability and Wall Motion , 2006, Circulation.

[23]  E. Marbán,et al.  Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles. , 2015, Journal of the American College of Cardiology.

[24]  Yin Wu,et al.  MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model , 2007, Magnetic resonance in medicine.

[25]  Rohan Dharmakumar,et al.  In vivo three‐dimensional high resolution cardiac diffusion‐weighted MRI: A motion compensated diffusion‐prepared balanced steady‐state free precession approach , 2014, Magnetic resonance in medicine.

[26]  K. Cheng,et al.  Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy , 2015, Stem cells international.

[27]  E. Marbán,et al.  Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy , 2014, Stem cell reports.

[28]  Laurence Zitvogel,et al.  Exosomes: composition, biogenesis and function , 2002, Nature Reviews Immunology.

[29]  Douglas Losordo,et al.  Exosomes and cardiac repair after myocardial infarction. , 2014, Circulation research.

[30]  David Atkinson,et al.  Second‐order motion‐compensated spin echo diffusion tensor imaging of the human heart , 2016, Magnetic resonance in medicine.

[31]  Matthew D. Budde,et al.  Examining brain microstructure using structure tensor analysis of histological sections , 2012, NeuroImage.

[32]  R. Bonow,et al.  Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction). , 2014, Journal of the American College of Cardiology.

[33]  Yong Chen,et al.  The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation in Hearts with Postinfarct LV Remodeling , 2015, Cell Transplantation.

[34]  Elena Aikawa,et al.  Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers in Infarcted Myocardium , 2009, Circulation. Cardiovascular imaging.

[35]  Himanshu Bhat,et al.  Diffusion MRI in the heart , 2015, NMR in biomedicine.

[36]  E. Marbán,et al.  Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair. , 2014, JACC. Heart failure.

[37]  E. McVeigh,et al.  Phase‐sensitive inversion recovery for detecting myocardial infarction using gadolinium‐delayed hyperenhancement † , 2002, Magnetic resonance in medicine.

[38]  H. Perlman,et al.  Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity , 2011, Circulation research.

[39]  D. Altman,et al.  Agreement Between Methods of Measurement with Multiple Observations Per Individual , 2007, Journal of biopharmaceutical statistics.

[40]  E. Marbán,et al.  Intracoronary Delivery of Self-Assembling Heart-Derived Microtissues (Cardiospheres) for Prevention of Adverse Remodeling in a Pig Model of Convalescent Myocardial Infarction , 2015, Circulation. Cardiovascular interventions.

[41]  Debiao Li,et al.  In vivo diffusion‐tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion‐preparation approach , 2016, Magnetic resonance in medicine.

[42]  Shihua Zhao,et al.  Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance , 2015, Journal of Cardiovascular Magnetic Resonance.

[43]  Jeffrey W Holmes,et al.  Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts , 2012, The Journal of physiology.

[44]  M. Friedrich,et al.  Comparison of long and short axis quantification of left ventricular volume parameters by cardiovascular magnetic resonance, with ex-vivo validation , 2011, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[45]  Thorsten Feiweier,et al.  In vivo diffusion tensor MRI of the human heart: Reproducibility of breath‐hold and navigator‐based approaches , 2013, Magnetic resonance in medicine.

[46]  Debiao Li,et al.  High efficiency coronary MR angiography with nonrigid cardiac motion correction , 2016, Magnetic resonance in medicine.

[47]  Theo Gasser,et al.  Assessing intrarater, interrater and test–retest reliability of continuous measurements , 2002, Statistics in medicine.

[48]  Scott D Flamm,et al.  Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing , 2013, Journal of Cardiovascular Magnetic Resonance.

[49]  Daniel Berman,et al.  Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial , 2012, The Lancet.