RELAY, Ramucirumab Plus Erlotinib (RAM+ERL) in Untreated Metastatic EGFR-Mutant NSCLC (EGFR+ NSCLC): Association Between TP53 Status and Clinical Outcome.
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S. Novello | L. Paz-Ares | M. Nishio | M. Reck | E. Garon | S. Popat | C. Visseren-Grul | M. Ceccarelli | Kazuhiko Nagakawa | Hillary T. Graham | H. Graham
[1] M. Oki,et al. Phase 3 Clinical Trial for the Combination of Erlotinib plus Ramucirumab Compared with Osimertinib in Previously Untreated Advanced or Recurrent Non–Small Cell Lung Cancer Positive for the L858R Mutation of EGFR: REVOL858R (WJOG14420L) , 2021, Clinical Lung Cancer.
[2] G. Shapiro,et al. 516MO Phase I/II study of eprenetapopt (APR-246) in combination with pembrolizumab in patients with solid tumor malignancies , 2021, Annals of Oncology.
[3] C. Gridelli,et al. 1207O Bevacizumab + erlotinib vs erlotinib alone as first-line treatment of pts with EGFR mutated advanced non squamous NSCLC: Final analysis of the multicenter, randomized, phase III BEVERLY trial , 2021, Annals of Oncology.
[4] Ying Cheng,et al. Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study. , 2021, Cancer cell.
[5] R. Stahel,et al. VP3-2021: A randomized phase II study of second-line osimertinib (Osi) and bevacizumab (Bev) versus Osi in advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and T790M mutations (mt): Results from the ETOP BOOSTER trial , 2021, Annals of Oncology.
[6] G. Blandino. Drugging the Master Regulator TP53 in Cancer: Mission Possible? , 2021, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] N. Hanna,et al. P76.62 RAMOSE: An Open-Label Randomized Phase II Study of Osimertinib with or without Ramucirumab in TKI-Naïve EGFR-Mutant Metastatic NSCLC , 2021 .
[8] Jiqiang Yao,et al. Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes , 2021, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] K. Kiura,et al. VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene‐driven non‐small‐cell lung cancers , 2021, Cancer science.
[10] Cheng-Bo Han,et al. Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review , 2020, Frontiers in Oncology.
[11] Yi-long Wu,et al. Predictive and Prognostic Potential of TP53 in Patients With Advanced Non-Small-Cell Lung Cancer Treated With EGFR-TKI: Analysis of a Phase III Randomized Clinical Trial (CTONG 0901). , 2020, Clinical lung cancer.
[12] X. Le,et al. Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC. , 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[13] L. Spaggiari,et al. Understanding EGFR heterogeneity in lung cancer , 2020, ESMO Open.
[14] M. Duffy,et al. Targeting p53 for the treatment of cancer. , 2020, Seminars in cancer biology.
[15] M. Fassan,et al. TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy , 2020, Cancers.
[16] K. Nishio,et al. RELAY+: Exploratory study of ramucirumab plus gefitinib in untreated patients (pts) with epidermal growth factor receptor (EGFR)-mutated metastatic non-small cell lung cancer (NSCLC). , 2020 .
[17] L. Landi,et al. Concomitant TP53 Mutation Confers Worse Prognosis in EGFR-Mutated Non-Small Cell Lung Cancer Patients Treated with TKIs , 2020, Journal of clinical medicine.
[18] H. Hou,et al. Prognostic value of TP53 concurrent mutations for EGFR- TKIs and ALK-TKIs based targeted therapy in advanced non-small cell lung cancer: a meta-analysis , 2019, BMC Cancer.
[19] J. Shih,et al. Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial. , 2019, The Lancet. Oncology.
[20] Yufen Zhao,et al. Association between TP53 mutations and efficacy of Osimertinib for brain metastasis from EGFR-mutant lung cancer , 2019, Annals of Oncology.
[21] D. Pe’er,et al. Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes. , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[22] E. Giovannetti,et al. Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer , 2019, British Journal of Cancer.
[23] R. Kurzrock,et al. Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues , 2019, Cancer biology & therapy.
[24] R. Franco,et al. Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications , 2019, International journal of medical sciences.
[25] Chuantao Zhang,et al. Concurrent TP53 mutations predict poor outcomes of EGFR-TKI treatments in Chinese patients with advanced NSCLC , 2019, Cancer management and research.
[26] T. Yamanaka,et al. A multicenter, open label, randomized phase II study of osimertinib plus ramucirumab versus osimertinib alone as initial chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer: TORG1833. , 2019, Journal of Clinical Oncology.
[27] T. Yamanaka,et al. The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV , 2019, International Journal of Clinical Oncology.
[28] A. Gemma,et al. Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial. , 2019, The Lancet. Oncology.
[29] Matthew P. Goetz,et al. NCCN CLINICAL PRACTICE GUIDELINES IN ONCOLOGY , 2019 .
[30] C. Langer,et al. Influence of TP53 Mutation on Survival in Patients With Advanced EGFR-Mutant Non-Small-Cell Lung Cancer. , 2018, JCO precision oncology.
[31] Ying Cheng,et al. Osimertinib in Untreated EGFR‐Mutated Advanced Non–Small‐Cell Lung Cancer , 2018, The New England journal of medicine.
[32] B. Han,et al. First-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance therapy for patients with advanced EGFR mutation-positive lung adenocarcinoma (CONVINCE): a phase 3, open-label, randomized study , 2017, Annals of oncology : official journal of the European Society for Medical Oncology.
[33] S. Kobayashi,et al. Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes. , 2017, Lung cancer.
[34] Matteo Canale,et al. Impact of TP53 Mutations on Outcome in EGFR-Mutated Patients Treated with First-Line Tyrosine Kinase Inhibitors , 2016, Clinical Cancer Research.
[35] R. Yelensky,et al. TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics , 2016, Molecular Cancer Therapeutics.
[36] T. Yen,et al. Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma , 2016, Oncotarget.
[37] D. Liebner,et al. TP53 mutational status is predictive of pazopanib response in advanced sarcomas. , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.
[38] S Senan,et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[39] L. Sequist,et al. Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. , 2015, The Lancet. Oncology.
[40] Pierre Validire,et al. VEGF-A Expression Correlates with TP53 Mutations in Non-Small Cell Lung Cancer: Implications for Antiangiogenesis Therapy. , 2015, Cancer research.
[41] R. Rosell,et al. Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer , 2014, Clinical Cancer Research.
[42] G. Bhanot,et al. Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway , 2012, British Journal of Cancer.
[43] A. Mes-Masson,et al. p53 inhibits angiogenesis by inducing the production of Arresten. , 2012, Cancer research.
[44] Akira Mogi,et al. TP53 Mutations in Nonsmall Cell Lung Cancer , 2011, Journal of biomedicine & biotechnology.
[45] N. Ridgway,et al. Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update. , 2011, Journal of thoracic disease.
[46] H. Greulich,et al. The genomics of lung adenocarcinoma: opportunities for targeted therapies. , 2010, Genes & cancer.
[47] Y. Yatabe,et al. EGFR T790M mutation: a double role in lung cancer cell survival? , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[48] J. Manola,et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. , 2007, The New England journal of medicine.
[49] Michael R. Green,et al. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome , 2007, Journal of Molecular Medicine.
[50] J. Bergh,et al. The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.