Clinical Advances of Recent Discoveries about the Interaction between Circadian and Serotoninergic Systems

The circadian rhythm and the serotonergic system have anatomical connections and convergent functional association influencing the functioning of the central nervous system. Serotonin is present in several areas of the brain that regulate the circadian rhythm and deregulations in the levels of dopamine have been associated with neurological disorders such as autism, depression, and anxiety. New discoveries have been made about the association of serotonin and circadian rhythm. Thus, the objective of the study was to address the clinical advances on the interaction of these two systems. For this, a bibliographic review in databases Scielo, PubMed, Lilacs and Cochrane was carried out, in which 40 full articles were used. Through genetic, physiological and clinical evidence, the 5-HT and circadian systems of the brain are connected to each other and converge to regulate affective behaviors and pathologies. Rates ever-increasing related to use of selective inhibitors of serotonin reuptake and other drug classes of serotonergic influences are observed, as well as an increasing prevalence of circadian disorders, especially linked to sleep problems.

[1]  Seung-Gul Kang,et al.  Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity , 2016, Scientific Reports.

[2]  A. Gauthier,et al.  Is there a circadian rhythm of postural control and perception of the vertical? , 2016, Chronobiology international.

[3]  M. Margaglione,et al.  The Relationship between Personality Traits, the 5HTT Polymorphisms, and the Occurrence of Anxiety and Depressive Symptoms in Elite Athletes , 2016, PloS one.

[4]  Jiwen Liu,et al.  Effect of 5-HT2A receptor polymorphisms and occupational stress on self-reported sleep quality: a cross-sectional study in Xinjiang, China. , 2016, Sleep medicine.

[5]  Kerang Zhang,et al.  Psychosocial mechanisms of serotonin transporter's genetic polymorphism in susceptibility to major depressive disorder: mediated by trait coping styles and interacted with life events. , 2016, American journal of translational research.

[6]  J. Gooley.  How Much Day-To-Day Variability in Sleep Timing Is Unhealthy? , 2016, Sleep.

[7]  H. Landolt,et al.  Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy. , 2016, Annual review of pharmacology and toxicology.

[8]  D. Pollak,et al.  Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior , 2015, Annals of medicine.

[9]  Takayuki Ishiwata,et al.  Influence of circadian disruption on neurotransmitter levels, physiological indexes, and behaviour in rats , 2015, Chronobiology international.

[10]  A. Kalsbeek,et al.  Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease , 2015, Neuroscience.

[11]  R. Dyck,et al.  Effects of lighting condition on circadian behavior in 5-HT1A receptor knockout mice , 2015, Physiology & Behavior.

[12]  G. Martinotti,et al.  Agomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression , 2015, International journal of molecular sciences.

[13]  M. Gahr.  Agomelatine in the Treatment of Major Depressive Disorder: An Assessment of Benefits and Risks , 2014, Current neuropharmacology.

[14]  R. Zhong,et al.  The Association of 5-HT2A, 5-HTT, and LEPR Polymorphisms with Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis , 2014, PloS one.

[15]  S. Kuo,et al.  Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. , 2014, Journal of affective disorders.

[16]  T. Partonen,et al.  CRY2 Genetic Variants Associate with Dysthymia , 2013, PloS one.

[17]  D. McMahon,et al.  Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues , 2011, Neuroscience.

[18]  S Hartley,et al.  Circadian rhythms, melatonin and depression. , 2011, Current pharmaceutical design.

[19]  John C. Axley,et al.  Perinatal photoperiod imprints the circadian clock , 2010, Nature Neuroscience.

[20]  Christian Otte,et al.  Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction , 2010, Biological Psychology.

[21]  P. Gorwood.  Review: Restoring circadian rhythms: a new way to successfully manage depression , 2010, Journal of psychopharmacology.

[22]  L. Peltonen,et al.  An Association Analysis of Circadian Genes in Anxiety Disorders , 2010, Biological Psychiatry.

[23]  T. Paunio,et al.  CRY2 Is Associated with Depression , 2010, PloS one.

[24]  Matcheri Keshavan,et al.  Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. , 2009, Bipolar disorders.

[25]  M. Ikeda,et al.  CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients , 2009, NeuroMolecular Medicine.

[26]  S. Kasper,et al.  Beyond the monoaminergic hypothesis: Agomelatine, a new antidepressant with an innovative mechanism of action , 2009, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[27]  Mario Maj,et al.  The circadian basis of mood disorders: Recent developments and treatment implications , 2008, European Neuropsychopharmacology.

[28]  P. Nolan,et al.  When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing , 2008, PLoS genetics.

[29]  P. Pévet,et al.  Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. , 2007, Endocrinology.

[30]  T. Paunio,et al.  Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression , 2007, Annals of medicine.

[31]  J. Sprouse,et al.  Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing , 2006, Biological Psychiatry.

[32]  G. E. Pickard,et al.  Photic Entrainment Is Altered in the 5-HT 1B Receptor Knockout Mouse , 2006, Journal of biological rhythms.

[33]  H. Manev,et al.  Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum , 2005, Neuroscience.

[34]  T. Kendrick,et al.  Selective serotonin reuptake inhibitors , 2005, British medical journal.

[35]  P. Pévet,et al.  Circadian tryptophan hydroxylase levels and serotonin release in the suprachiasmatic nucleus of the rat , 2002, The European journal of neuroscience.

[36]  Yoshiyuki Sakaki,et al.  Circadian Rhythms in Isolated Brain Regions , 2002, The Journal of Neuroscience.

[37]  G. E. Pickard,et al.  TFMPP, a 5HT1B receptor agonist, inhibits light-induced phase shifts of the circadian activity rhythm and c-Fos expression in the mouse suprachiasmatic nucleus , 1997, Neuroscience Letters.

[38]  J. Zeitzer.  Control of sleep and wakefulness in health and disease. , 2013, Progress in molecular biology and translational science.

[39]  M. Popoli.  Agomelatine , 2009, CNS drugs.