Cancer stem cell-directed therapies: recent data from the laboratory and clinic.

[1]  O. Er,et al.  Cancer Stem Cells in Solid Tumors , 2009, Oncology Research and Treatment.

[2]  Sabine Riethdorf,et al.  Review: Biological relevance of disseminated tumor cells in cancer patients , 2008, International journal of cancer.

[3]  M. Todaro,et al.  Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity , 2008, Proceedings of the National Academy of Sciences.

[4]  J. Gribben,et al.  Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. , 2008, Blood.

[5]  M. Clarke,et al.  Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy , 2008, PloS one.

[6]  Ian A. White,et al.  CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. , 2008, The Journal of clinical investigation.

[7]  Susan G Hilsenbeck,et al.  Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. , 2008, Journal of the National Cancer Institute.

[8]  Ruud H. Brakenhoff,et al.  Detection, clinical relevance and specific biological properties of disseminating tumour cells , 2008, Nature Reviews Cancer.

[9]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[10]  M. Biffoni,et al.  Identification and expansion of the tumorigenic lung cancer stem cell population , 2008, Cell Death and Differentiation.

[11]  S. Fan,et al.  Significance of CD90+ cancer stem cells in human liver cancer. , 2008, Cancer cell.

[12]  Mohamed H. Sayegh,et al.  Identification of cells initiating human melanomas , 2008, Nature.

[13]  P. Lichter,et al.  Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients , 2008, Clinical Cancer Research.

[14]  M. Brittan,et al.  CD133: molecule of the moment , 2008, The Journal of pathology.

[15]  M. Carroll,et al.  An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. , 2007, Blood.

[16]  Xiaojie Li,et al.  Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). , 2007, Blood.

[17]  J. Dick,et al.  Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells" , 2007, Science.

[18]  John W M Martens,et al.  Circulating tumour cell detection on its way to routine diagnostic implementation? , 2007, European journal of cancer.

[19]  B. Ang,et al.  Cancer stem cell: target for anti‐cancer therapy , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  I. Weissman,et al.  Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. , 2007, Cell stem cell.

[21]  Daniel Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[22]  Satoshi Tanaka,et al.  Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region , 2007, Nature Biotechnology.

[23]  R. V. van Etten,et al.  Right on target: eradicating leukemic stem cells. , 2007, Trends in molecular medicine.

[24]  Michael F Clarke,et al.  The biology of cancer stem cells. , 2007, Annual review of cell and developmental biology.

[25]  M. Todaro,et al.  Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. , 2007, Cell stem cell.

[26]  C. Heeschen,et al.  Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. , 2007, Cell stem cell.

[27]  M. Mimeault,et al.  Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers , 2007, Journal of cellular and molecular medicine.

[28]  Aleksandar Dakic,et al.  Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells , 2007, Science.

[29]  A. López-Guillermo,et al.  The clinical use of antibodies in haematological malignancies. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.

[30]  Michael F. Clarke,et al.  Phenotypic characterization of human colorectal cancer stem cells , 2007, Proceedings of the National Academy of Sciences.

[31]  A. Cheung,et al.  Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential , 2007, Leukemia.

[32]  F. Michor.  Chronic Myeloid Leukemia Blast Crisis Arises from Progenitors , 2007, Stem cells.

[33]  C. Huff,et al.  Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma , 2007, Proceedings of the National Academy of Sciences.

[34]  P. Dirks,et al.  Cancer stem cells: at the headwaters of tumor development. , 2007, Annual review of pathology.

[35]  G. Sherlock,et al.  The prognostic role of a gene signature from tumorigenic breast-cancer cells. , 2007, The New England journal of medicine.

[36]  I. Weissman,et al.  Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma , 2007, Proceedings of the National Academy of Sciences.

[37]  P. Kearns,et al.  Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. , 2007, Blood.

[38]  M. Clarke,et al.  Cancer stem cells: models and concepts. , 2007, Annual review of medicine.

[39]  L. Ricci-Vitiani,et al.  Identification and expansion of human colon-cancer-initiating cells , 2007, Nature.

[40]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[41]  D. Printz,et al.  Expression of the target receptor CD33 in CD34+/CD38−/CD123+ AML stem cells , 2007, European journal of clinical investigation.

[42]  Frank Pajonk,et al.  The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. , 2006, Journal of the National Cancer Institute.

[43]  G. Broggi,et al.  Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells , 2006, Nature.

[44]  Mark W. Dewhirst,et al.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response , 2006, Nature.

[45]  K. Black,et al.  Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma , 2006, Molecular Cancer.

[46]  John Calvin Reed,et al.  Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. , 2006, Cancer cell.

[47]  Irving L Weissman,et al.  Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. , 2006, Cancer research.

[48]  J. Dick,et al.  Targeting of CD44 eradicates human acute myeloid leukemic stem cells , 2006, Nature Medicine.

[49]  D. Stearns,et al.  Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. , 2006, Cancer research.

[50]  L. Ricci-Vitiani,et al.  Chemotherapy resistance of glioblastoma stem cells , 2006, Cell Death and Differentiation.

[51]  C. Huff,et al.  Strategies to eliminate cancer stem cells: clinical implications. , 2006, European journal of cancer.

[52]  S. Morrison,et al.  Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells , 2006, Nature.

[53]  Xi C. He,et al.  PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention , 2006, Nature.

[54]  M. Clarke,et al.  Stem Cells and Cancer: Two Faces of Eve , 2006, Cell.

[55]  H. Li,et al.  Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells , 2006, Oncogene.

[56]  J. Nolta,et al.  Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells. , 2006, Blood.

[57]  R. Hill.  Identifying cancer stem cells in solid tumors: case not proven. , 2006, Cancer research.

[58]  Max S Wicha,et al.  Cancer stem cells: an old idea--a paradigm shift. , 2006, Cancer research.

[59]  T. Lister,et al.  AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. , 2006, Blood.

[60]  S. Hammond,et al.  MicroRNAs as oncogenes. , 2006, Current opinion in genetics & development.

[61]  T. Lister,et al.  Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. , 2005, Blood.

[62]  N. Maitland,et al.  Prospective identification of tumorigenic prostate cancer stem cells. , 2005, Cancer research.

[63]  P. Dalerba,et al.  Identification of pancreatic cancer stem cells. , 2006, Cancer research.

[64]  I. Weissman,et al.  Stem cell research: paths to cancer therapies and regenerative medicine. , 2005, JAMA.

[65]  Q. Waisfisz,et al.  High Stem Cell Frequency in Acute Myeloid Leukemia at Diagnosis Predicts High Minimal Residual Disease and Poor Survival , 2005, Clinical Cancer Research.

[66]  Martin A. Nowak,et al.  Dynamics of chronic myeloid leukaemia , 2005, Nature.

[67]  D. Gary Gilliland,et al.  Cancer biology: Summing up cancer stem cells , 2005, Nature.

[68]  K. Anderson,et al.  Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia , 2005, Nature Medicine.

[69]  T. Lister,et al.  Characterization of Cells with a High Aldehyde Dehydrogenase Activity from Cord Blood and Acute Myeloid Leukemia Samples , 2005, Stem cells.

[70]  Michael Dean,et al.  Tumour stem cells and drug resistance , 2005, Nature Reviews Cancer.

[71]  D. Gilliland,et al.  Leukaemia stem cells and the evolution of cancer-stem-cell research , 2005, Nature Reviews Cancer.

[72]  C. Eaves,et al.  Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease , 2005, Leukemia.

[73]  Maria Athelogou,et al.  Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[74]  M. Stojkovic,et al.  Phenotypic Characterization of Murine Primitive Hematopoietic Progenitor Cells Isolated on Basis of Aldehyde Dehydrogenase Activity , 2004, Stem cells.

[75]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[76]  N. Goulden,et al.  Characterization of acute lymphoblastic leukemia progenitor cells. , 2004, Blood.

[77]  Sanghyuk Lee,et al.  MicroRNA genes are transcribed by RNA polymerase II , 2004, The EMBO journal.

[78]  C. Jordan,et al.  Mechanisms controlling pathogenesis and survival of leukemic stem cells , 2004, Oncogene.

[79]  J. Nolta,et al.  Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. , 2004, Blood.

[80]  Laurie E Ailles,et al.  Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. , 2004, The New England journal of medicine.

[81]  K. Kinzler,et al.  Cancer genes and the pathways they control , 2004, Nature Medicine.

[82]  H. Zhang,et al.  Isolation and characterization of the CD133+ precursors from the ventricular zone of human fetal brain by magnetic affinity cell sorting , 2004, Biotechnology Letters.

[83]  Richard J. Jones,et al.  Cancer stem cells: are we missing the target? , 2004, Journal of the National Cancer Institute.

[84]  C. Huff,et al.  Characterization of clonogenic multiple myeloma cells. , 2004, Blood.

[85]  Irving L Weissman,et al.  Biology of hematopoietic stem cells and progenitors: implications for clinical application. , 2003, Annual review of immunology.

[86]  Daniel H. Geschwind,et al.  Cancerous stem cells can arise from pediatric brain tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[87]  Cynthia Hawkins,et al.  Identification of a cancer stem cell in human brain tumors. , 2003, Cancer research.

[88]  Y. Guan,et al.  Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). , 2003, Blood.

[89]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[90]  W. Hiddemann,et al.  Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group studies. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[91]  D. Howard,et al.  Preferential induction of apoptosis for primary human leukemic stem cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[92]  M. Slovak,et al.  Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. , 2002, Blood.

[93]  Mina J Bissell,et al.  Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. , 2002, Genes & development.

[94]  B. E. C. Oiffier,et al.  CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma , 2002 .

[95]  T. Barbui,et al.  CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. , 2001, Blood.

[96]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[97]  T. Tuschl,et al.  Identification of Novel Genes Coding for Small Expressed RNAs , 2001, Science.

[98]  Elise C. Kohn,et al.  The microenvironment of the tumour–host interface , 2001, Nature.

[99]  D. Olive,et al.  Human acute myeloid leukemia CD34+/CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. , 2000, Cancer research.

[100]  I. Weissman,et al.  AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[101]  I. Weissman,et al.  Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer. , 2000, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[102]  D. Olive,et al.  The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): reduced immunogenicity and high frequency of CD34+/CD38− leukemic progenitors , 1999, Leukemia.

[103]  C. Eaves,et al.  Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. , 1999, Blood.

[104]  J. Ritz,et al.  PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. , 1999, Human molecular genetics.

[105]  C. Eaves,et al.  Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. , 1998, Differentiation; research in biological diversity.

[106]  T. Matsuda,et al.  Lack of prognostic significance of CD34 expression in adult AML when FAB M0 and M3 are excluded , 1998, American journal of hematology.

[107]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[108]  J. Matthews,et al.  Prognostic value of immunophenotyping in acute myeloid leukemia. Australian Leukaemia Study Group. , 1994, Blood.

[109]  M. Caligiuri,et al.  A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.

[110]  R. Notaro,et al.  PROGNOSTIC IRRELEVANCE OF CD34 IN ACUTE MYELOID LEUKAEMIA , 1992, British journal of haematology.

[111]  I. Weissman,et al.  Isolation of a candidate human hematopoietic stem-cell population. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[112]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[113]  D. Tarin,et al.  Low incidence of tumourigenicity in agarose colonies from spontaneous murine mammary tumours. , 1989, Differentiation; research in biological diversity.

[114]  J. Griffin,et al.  Clonogenic cells in acute myeloblastic leukemia. , 1986, Blood.

[115]  J. Griffin,et al.  Heterogeneity of clonogenic cells in acute myeloblastic leukemia. , 1985, The Journal of clinical investigation.

[116]  E. McCulloch,et al.  Mouse myeloma tumor stem cells: a primary cell culture assay. , 1971, Journal of the National Cancer Institute.

[117]  R. H. Levin,et al.  The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. , 1965, Blood.

[118]  W. R. Bruce,et al.  A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivo , 1963, Nature.

[119]  C. Southam,et al.  Quantitative studies of autotransplantation of human cancer. Preliminary report , 1961 .

[120]  J. Lederberg,et al.  REPLICA PLATING AND INDIRECT SELECTION OF BACTERIAL MUTANTS , 1952, Journal of bacteriology.

[121]  E. Lagasse,et al.  Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer , 2008, Gene Therapy.

[122]  C. Huff,et al.  Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. , 2008, Cancer research.

[123]  I. Bayazitov,et al.  A perivascular niche for brain tumor stem cells. , 2007, Cancer cell.

[124]  W. V. Van Schooten,et al.  The future of antibody therapy. , 2006, Ernst Schering Foundation symposium proceedings.

[125]  Lurias,et al.  MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE’-’ , 2003 .

[126]  T. Holyoake,et al.  Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. , 2002, Blood.

[127]  Pierre Morel,et al.  CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. , 2002, The New England journal of medicine.

[128]  D. Neal,et al.  Summary of the , 1994 .

[129]  M. Héry,et al.  In vitro clonogenicity in relation to kinetic and clinicopathological features of breast cancer. , 1988, Bulletin du cancer.

[130]  C. Southam,et al.  QUANTITATIVE STUDIES OF AUTOTRANSPLANTATION OF HUMAN CANCER , 1961 .