Endothelial dysfunction and type of cigarette smoked: the impact of ‘light’ versus regular cigarette smoking

Acute cigarette smoking leads to temporary endothelial dysfunction, which is an early event in atherogenesis. Sufficient data concerning the effect of cigarettes with low tar and nicotine yield are lacking. Seventeen healthy individuals (nine women, eight men, aged 27.8 3.6 years) were subjected to evaluation of endothelial function by means of endothelium-dependent, flow-mediated dilatation (FMD) of the brachial artery, before, immediately after and 30, 60 and 90 min after smoking a regular cigarette (nicotine 0.9 mg, tar 12 mg) or the corresponding ‘light’ cigarette (nicotine 0.6 mg, tar 8 mg). The following day, measurements were repeated after smoking the opposite kind of cigarette. Baseline FMD was 6.1 1.6% and 7.2 2.0% in the light and regular cigarette groups, respectively (p 1/4 NS). The overall effect of the regular cigarette over time on FMD compared with the light cigarette was significantly different (F 1/4 3.039, p 1/4 0.023). FMD was significantly depressed after smoking both types (light: F 1/4 8.192, p < 0.001; regular: F 1/4 16.698, p < 0.001). Immediately after smoking, FMD declined in both groups (light: 3.0 2.4% and regular: 1.6 3.2%, p < 0.001 and p < 0.001, respectively), and it remained significantly depressed in the regular cigarette group at 30 min (0.75 1.5%, p < 0.001) and 60 min (3.5 3.1%, p 1/4 0.024), while in the light cigarette group FMD differences were abolished at 30, 60 and 90 min after smoking. In conclusion, acute smoking of both regular and light cigarettes leads to temporary vasomotor dysfunction; its duration is shorter after smoking a ‘light’ cigarette.

[1]  E. Benjamin,et al.  Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. , 2002, Journal of the American College of Cardiology.

[2]  M. Woodward Is compulsory restriction of tar yield of cigarettes a worthwhile public health policy? , 2001, American journal of preventive medicine.

[3]  A. Avcı,et al.  Acute effects of smoking of cigarettes with different tar content on plasma oxidant/antioxidant status. , 2000, Inhalation toxicology.

[4]  J. Lekakis,et al.  Effects of acute cigarette smoking on endothelium-dependent arterial dilatation in normal subjects. , 1998, The American journal of cardiology.

[5]  J. Lekakis,et al.  Effect of acute cigarette smoking on endothelium-dependent brachial artery dilatation in healthy individuals. , 1997, The American journal of cardiology.

[6]  J. Deanfield,et al.  Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. , 1996, The New England journal of medicine.

[7]  W E Haefeli,et al.  Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. , 1995, Circulation.

[8]  D. Celermajer,et al.  Cigarette Smoking Is Associated With Dose‐Related and Potentially Reversible Impairment of Endothelium‐Dependent Dilation in Healthy Young Adults , 1993, Circulation.

[9]  J. K. Lloyd,et al.  Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis , 1992, The Lancet.

[10]  S. Shapiro,et al.  Tar content of cigarettes in relation to lung cancer. , 1989, American journal of epidemiology.

[11]  D. Petitti,et al.  Evidence for compensation in smokers of low yield cigarettes. , 1983, International journal of epidemiology.