Hyaluron Filler Containing Lidocaine on a CPM Basis for Lip Augmentation: Reports from Practical Experience

Abstract Lip augmentation with hyaluronic acid fillers is established. As monophasic polydensified hyaluronic acid products with variable density, CPM-HAL1 (Belotero Balance Lidocaine, Merz Aesthetics, Raleigh, NC) and CPM-HAL2 (Belotero Intense Lidocaine, Merz Aesthetics, Raleigh, NC) are qualified for beautification and particularly natural-looking rejuvenation, respectively. The aim of this article was to assess the handling and outcome of lip augmentation using the lidocaine-containing hyaluronic acid fillers, CPM-HAL1 and CPM-HAL2. Data were documented from patients who received lip augmentation by means of beautification and/or rejuvenation using CPM-HAL1 and/or CPM-HAL2. Observation period was 4 months, with assessment of natural outcome, evenness, distribution, fluidity, handling, malleability, tolerability, as well as patient satisfaction and pain. A total of 146 patients from 21 German centers participated. Physicians rated natural outcome and evenness as good or very good for more than 95% of patients. Distribution, fluidity, handling, and malleability were assessed for both fillers as good or very good in more than 91% of patients. At every evaluation point, more than 93% of patients were very or very much satisfied with the product. A total of 125 patients (85.6%) experienced transient injection-related side effects. Pain intensity during the procedure was mild (2.72 ± 1.72 on the 0–10 pain assessment scale) and abated markedly within 30 minutes (0.42 ± 0.57). Lip augmentation with hyaluronic acid fillers produced a long-term cosmetic result. Due to the lidocaine content, procedural pain was low and transient. Accordingly, a high degree of patient satisfaction was achieved that was maintained throughout the observation period.

[1]  T. Flynn,et al.  A Blanching Technique for Intradermal Injection of the Hyaluronic Acid Belotero , 2013, Plastic and reconstructive surgery.

[2]  M. Kerscher,et al.  Efficacy, Safety, and Patient Satisfaction of a Monophasic Cohesive Polydensified Matrix Versus a Biphasic Nonanimal Stabilized Hyaluronic Acid Filler After Single Injection in Nasolabial Folds , 2013, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[3]  D. Murphy,et al.  Clinical, Cosmetic and Investigational Dermatology Juvéderm ® Volbella™ in the Perioral Area: a 12-month Prospective, Multicenter, Open-label Study , 2022 .

[4]  U. Kühne,et al.  Five-year retrospective review of safety, injected volumes, and longevity of the hyaluronic acid Belotero Basic for facial treatments in 317 patients. , 2012, Journal of drugs in dermatology : JDD.

[5]  W. Prager,et al.  A Prospective, Split‐Face, Randomized, Comparative Study of Safety and 12‐Month Longevity of Three Formulations of Hyaluronic Acid Dermal Filler for Treatment of Nasolabial Folds , 2012, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[6]  K. Cockerham,et al.  Hyaluronic acid dermal fillers: can adjunctive lidocaine improve patient satisfaction without decreasing efficacy or duration? , 2011, Patient preference and adherence.

[7]  W. Prager,et al.  A prospective, rater-blind, randomized comparison of the effectiveness and tolerability of Belotero ® Basic versus Restylane ® for correction of nasolabial folds. , 2010, European journal of dermatology : EJD.

[8]  S. Weinkle Injection techniques for revolumization of the perioral region with hyaluronic acid. , 2010, Journal of drugs in dermatology : JDD.

[9]  M. Lewis,et al.  Botulinum toxin cosmetic therapy correlates with a more positive mood , 2009, Journal of cosmetic dermatology.

[10]  G. Monheit,et al.  Comparative Physical Properties of Hyaluronic Acid Dermal Fillers , 2009, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[11]  K. Arndt,et al.  Evaluation of the Aging Face , 2009 .

[12]  J. Carruthers,et al.  A Validated Lip Fullness Grading Scale , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[13]  D. Sarnoff,et al.  Comparison of filling agents for lip augmentation. , 2008, Aesthetic surgery journal.

[14]  R. Glogau,et al.  Effect of Injection Techniques on the Rate of Local Adverse Events in Patients Implanted with Nonanimal Hyaluronic Acid Gel Dermal Fillers , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[15]  A. Cazzaniga,et al.  Hyaluronic acid gel fillers in the management of facial aging , 2008, Clinical interventions in aging.

[16]  R. Sprengelmeyer,et al.  Pharmacologic denervation of frown muscles enhances baseline expression of happiness and decreases baseline expression of anger, sadness, and fear. , 2003, Journal of the American Academy of Dermatology.