Ossification centre of the hyoid bone in DiGeorge syndrome and tetralogy of Fallot.

The incidence of radiographic visibility of the ossification centre of the body of the hyoid bone in radiographs taken during the first month of life was analysed for 34 autopsied infants: 16 with DiGeorge syndrome (DGS), 14 with tetralogy of Fallot (TOF), four with interrupted aortic arch (IAA) and a further 13, surviving infants with non-DGS TOF or non-DGS IAA. The incidence of visible hyoid ossification centre (HOC) was 75.7% in a control series of infants with neither congenital heart disease (CHD) nor DGS. Autopsied patients with DGS, TOF without DGS, and IAA without DGS showed a significantly low incidence of visible HOC. Infants with TOF (and possibly those with IAA) who did not have DGS and who did not die during infancy showed a normal incidence of visible HOC in radiographs taken during the first post-natal month. Radiological visibility of the HOC in the first post-natal month appears useful in the diagnosis of DGS and forms of CHD often seen in association with DGS and in assessing prognosis of neonates with certain types of CHD.

[1]  L. V. van Mierop,et al.  Interruption of the aortic arch and coarctation of the aorta: pathogenetic relations. , 1984, The American journal of cardiology.

[2]  J. Lauwerijns,et al.  Cardiovascular malformations in DiGeorge syndrome (congenital absence of hypoplasia of the thymus). , 1980, British heart journal.

[3]  J. F. Mancer,et al.  The spectrum of the DiGeorge syndrome. , 1979, The Journal of pediatrics.

[4]  D. Levin,et al.  Congenital absence of the pulmonary valve associated with congenital aplasia of the thymus (DiGeorge's syndrome). , 1974, The American journal of roentgenology, radium therapy, and nuclear medicine.

[5]  J. Pryse‐davies,et al.  Factors influencing development of secondary ossification centres in the fetus and newborn , 1974, Archives of disease in childhood.

[6]  Donaldson Sw,et al.  The anterior tubercle of the first cervical vertebra and the hyoid bone: their occurrence in newborn infants. , 1951 .

[7]  A CHRISTIE,et al.  Prevalence and distribution of ossification centers in the newborn infant. , 1949, American journal of diseases of children.

[8]  E. C. Dunham,et al.  A consideration of race and sex in relation to the growth and development of infants , 1939 .

[9]  J. W. Pryor.  Differences in the time of development of centers of ossification in the male and female skeleton , 1923 .

[10]  S. Garn,et al.  Radiographic standards for postnatal ossification and tooth calcification. , 1967, Medical radiography and photography.

[11]  A. H. Hill.  Fetal age assessment by centers of ossification , 1939 .