Analyses of sphingosine‐1‐phosphate in the context of transfusion: how much is in stored blood products and in patient blood?

Sphingosine‐1‐phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to investigate S1P concentrations in blood products during storage and in patient plasma after blood transfusion.

[1]  Hong Liu,et al.  Inverse Correlation Between Plasma Sphingosine-1-Phosphate and Ceramide Concentrations in Septic Patients and Their Utility in Predicting Mortality , 2019, Shock.

[2]  H. Völzke,et al.  Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss , 2018, Nature Medicine.

[3]  A. Nierhaus,et al.  Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? , 2017, Shock.

[4]  G. Schmitz,et al.  Analysis of platelet‐derived extracellular vesicles in plateletpheresis concentrates: a multicenter study , 2017, Transfusion.

[5]  M. Bahls,et al.  Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. , 2017, Clinica chimica acta; international journal of clinical chemistry.

[6]  S. Wehinger,et al.  Evaluation of store lesion in platelet obtained by apheresis compared to platelet derived from whole blood and its impact on the in vitro functionality. , 2015, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[7]  E. Schwedhelm,et al.  Decreased serum concentrations of sphingosine-1-phosphate in sepsis , 2015, Critical Care.

[8]  A. Morris,et al.  Granule-mediated release of sphingosine-1-phosphate by activated platelets. , 2014, Biochimica et biophysica acta.

[9]  N. Hemdan,et al.  Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate , 2014, Cellular Physiology and Biochemistry.

[10]  I. Matot,et al.  Aged erythrocytes: a fine wine or sour grapes? , 2013, British journal of anaesthesia.

[11]  D. Sessler,et al.  Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. , 2013, British journal of anaesthesia.

[12]  R. Charnigo,et al.  Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions , 2011, Clinical science.

[13]  H. Ohto,et al.  Overview on platelet preservation: better controls over storage lesion. , 2011, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[14]  B. Dahlbäck,et al.  Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M , 2011, Proceedings of the National Academy of Sciences.

[15]  K. Schrör,et al.  Release of sphingosine‐1‐phosphate from human platelets is dependent on thromboxane formation , 2011, Journal of thrombosis and haemostasis : JTH.

[16]  F. Thol,et al.  Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1‐phosphate , 2010, Journal of cellular biochemistry.

[17]  M. Tani,et al.  Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. , 2007, Biochemical and biophysical research communications.

[18]  J. Cyster,et al.  Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate , 2007, Science.

[19]  M. Gräler,et al.  Erythrocytes store and release sphingosine 1‐phosphate in blood , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  B. Simon,et al.  Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. , 2004, American journal of respiratory and critical care medicine.

[21]  H. Rabb,et al.  Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. , 2004, American journal of respiratory and critical care medicine.

[22]  J. Lovelock,et al.  The haemolysis of human red blood-cells by freezing and thawing. , 1953, Biochimica et biophysica acta.