Walnuts Increase Good Cholesterol ( HDL-Cholesterol ) and Prevent Coronary Artery Disease

Back ground: Hyperlipidemia is one of the important risk factor to develop coronary artery disease (CAD) leading to main cause of morbidity and mortality due to heart attack and cardiac arrhythmias. Decreased level of plasma HDL-cholesterol independently can cause CAD. Recent studies have proved that walnuts can increase plasma HDL-cholesterol if taken in specific amount per day regularly Place and duration of study: Lahore General Hospital, Lahore from January 2014 to April 2014. Methodology: The baseline values of HDL-cholesterol were measured at day-0 and day-60 by separating other lipoprotein fractions using chemical precipitation with Mg 2+ , then coupling the products of a cholesterol oxidase reaction. Forty hyperlipidemic patients were selected from Lahore General Hospital for the study. Age of patients ranged from 20 to 65 years. Both gender male and female patients were enrolled. They were advised to discontinue any hypolipidemic medications and foods. Patients suffering from any metabolic disease, renal impairment, liver disease, and already having any cardiac problems were excluded from the research study. Forty patients were divided in two groups, twenty individuals in each group. Group-1 was advised to take 30 grams of walnuts (without shell) per day for the period of eight weeks. Group-II was considered as control group and was advised not to take any dry fruit including walnuts. Results: In twenty hyperlipidemic patients, two months therapy with 30 grams of walnuts per day increase in HDL-cholesterol was 6.3 mg/dl which was significant change when analyzed biostatistically, showing p-value <0.01. Statistical analysis: Mean values with SD and SEM were analysed statistically by using SPSS version 16.1. P-value of <0.001 was considered as significant and p-value of >0.05 was considered as nonsignificant change. Conclusion: It was concluded that regular intake of specific amount of walnuts without shell can increase good cholesterol (HDL-cholesterol) in male and female patients of age range from 18-65 yrs.

[1]  M. Riwanto,et al.  High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease1 , 2013, Journal of Lipid Research.

[2]  P. Barter,et al.  Translation of High-Density Lipoprotein Function Into Clinical Practice: Current Prospects and Future Challenges , 2013, Circulation.

[3]  D. Rader,et al.  Novel HDL-directed pharmacotherapeutic strategies , 2011, Nature Reviews Cardiology.

[4]  P. Barter.  Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. , 2009, The American journal of cardiology.

[5]  R. Paoletti,et al.  Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. , 2007, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[6]  M. Martínez-González,et al.  Nut Consumption and Weight Gain in a Mediterranean Cohort: The SUN Study , 2007, Obesity.

[7]  J. Sabaté,et al.  Nuts and coronary heart disease: an epidemiological perspective , 2006, British Journal of Nutrition.

[8]  L. Andersen,et al.  Health benefits of nuts: potential role of antioxidants , 2006, British Journal of Nutrition.

[9]  E. Ros,et al.  Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. , 2006, Journal of the American College of Cardiology.

[10]  Gitaben K Patel.  Essential fats in walnuts are good for the heart and diabetes. , 2005, Journal of the American Dietetic Association.

[11]  L. Tapsell,et al.  Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus. , 2005, Journal of the American Dietetic Association.

[12]  Alice Owen,et al.  Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. , 2004, Diabetes care.

[13]  W. Willett,et al.  Frequent nut consumption and decreased risk of cholecystectomy in women. , 2004, The American journal of clinical nutrition.

[14]  E. Ros,et al.  A Walnut Diet Improves Endothelial Function in Hypercholesterolemic Subjects: A Randomized Crossover Trial , 2004 .

[15]  Toshiyuki Fukuda,et al.  Antioxidative polyphenols from walnuts (Juglans regia L.). , 2003, Phytochemistry.

[16]  D. Capuzzi,et al.  Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors. , 2002, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[17]  A. Waterhouse,et al.  Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. , 2001, The Journal of nutrition.

[18]  P. Kris-Etherton,et al.  An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans , 2007 .

[19]  P. Kris-Etherton,et al.  Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. , 2004, The Journal of nutrition.