CC chemokine receptor 2 is required for CD 8-induced graft-versus-host disease

Department of Medicine and Immunology, and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901.

[1]  C. Martínez-A,et al.  CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses. , 2005, Blood.

[2]  J. Serody,et al.  Leukocyte migration and graft-versus-host disease. , 2005, Blood.

[3]  M. Remberger,et al.  Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation. , 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[4]  S. Fu,et al.  FTY720-Enhanced T Cell Homing Is Dependent on CCR2, CCR5, CCR7, and CXCR4: Evidence for Distinct Chemokine Compartments1 , 2004, The Journal of Immunology.

[5]  W. Kuziel,et al.  Differential expression of chemokines and chemokine receptors in murine islet allografts: the role of CCR2 and CCR5 signaling pathways. , 2004, Journal of the American Society of Nephrology : JASN.

[6]  F. Balkwill.  Cancer and the chemokine network , 2004, Nature Reviews Cancer.

[7]  M. Mack,et al.  CCR2-Dependent Trafficking of F4/80dim Macrophages and CD11cdim/intermediate Dendritic Cells Is Crucial for T Cell Recruitment to Lungs Infected with Mycobacterium tuberculosis1 , 2004, The Journal of Immunology.

[8]  M. V. D. van den Brink,et al.  Kinetics of gene expression in murine cutaneous graft-versus-host disease. , 2004, The American journal of pathology.

[9]  U. V. von Andrian,et al.  Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. , 2004, Annual review of immunology.

[10]  C. Hogaboam,et al.  A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. , 2004, Blood.

[11]  R. Blasberg,et al.  A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[12]  H. Sano,et al.  Effect of FK506 on donor T-cell functions that are responsible for graft-versus-host disease and graft-versus-leukemia effect , 2004, Transplantation.

[13]  B. Rollins,et al.  Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[14]  S. Milz,et al.  Dual Role of CCR2 during Initiation and Progression of Collagen-Induced Arthritis: Evidence for Regulatory Activity of CCR2+ T Cells1 , 2004, The Journal of Immunology.

[15]  F. Appelbaum,et al.  The current status of hematopoietic cell transplantation. , 2003, Annual review of medicine.

[16]  Y. Kalkonde,et al.  CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease 1 , 2003, The Journal of Immunology.

[17]  S. Clouthier,et al.  Role of CXCR3-induced donor T-cell migration in acute GVHD. , 2003, Experimental hematology.

[18]  M. V. D. van den Brink,et al.  IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. , 2003, The Journal of clinical investigation.

[19]  David E. Misek,et al.  Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays. , 2003, Blood.

[20]  I. Charo,et al.  Chemokine Receptor 2 (CCR2) in Atherosclerosis, Infectious Diseases, and Regulation of T‐Cell Polarization , 2003, Microcirculation.

[21]  R. Bronson,et al.  Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. , 2003, The Journal of clinical investigation.

[22]  M. Suematsu,et al.  Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction , 2003, Nature Immunology.

[23]  R. Fairchild,et al.  Chemokines: directing leukocyte infiltration into allografts. , 2002, Current opinion in immunology.

[24]  SY. Tan,et al.  T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease , 2002, Bone Marrow Transplantation.

[25]  M. Dorf,et al.  Differential Roles of CC Chemokine Ligand 2/Monocyte Chemotactic Protein-1 and CCR2 in the Development of T1 Immunity1 , 2002, The Journal of Immunology.

[26]  B. Rollins,et al.  Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. , 2002, Cytokine.

[27]  S. Burakoff,et al.  Cytolytic pathways in haematopoietic stem-cell transplantation , 2002, Nature Reviews Immunology.

[28]  A. Proudfoot.  Chemokine receptors: multifaceted therapeutic targets , 2002, Nature Reviews Immunology.

[29]  R. Soiffer,et al.  The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. , 2001, Blood.

[30]  Cun-Hui Zhang,et al.  Two-sample tests for growth curves under dependent right censoring , 2001 .

[31]  T. Moore,et al.  Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling1 , 2001, The Journal of Immunology.

[32]  W. Kuziel,et al.  Lack of CCR2 Results in Increased Mortality and Impaired Leukocyte Activation and Trafficking Following Infection of the Central Nervous System with a Neurotropic Coronavirus1 , 2001, The Journal of Immunology.

[33]  M. Burdick,et al.  Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. , 2001, The Journal of clinical investigation.

[34]  J. Flynn,et al.  Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. Appelbaum,et al.  Haematopoietic cell transplantation as immunotherapy , 2001, Nature.

[36]  M. V. D. van den Brink,et al.  Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. , 2001, Blood.

[37]  H. Brühl,et al.  Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice1 , 2001, The Journal of Immunology.

[38]  B. Rollins,et al.  Chemokines and disease , 2001, Nature Immunology.

[39]  J. Cyster,et al.  Chemokines as regulators of T cell differentiation , 2001, Nature Immunology.

[40]  I. Charo,et al.  A Mechanism for the Impaired IFN-γ Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses1 , 2000, The Journal of Immunology.

[41]  C. Mackay,et al.  T-cell function and migration. Two sides of the same coin. , 2000, The New England journal of medicine.

[42]  H. Weiner,et al.  Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2) , 2000, The Journal of experimental medicine.

[43]  W. Kuziel,et al.  Cc Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis , 2000, The Journal of experimental medicine.

[44]  W. Kuziel,et al.  Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells , 2000, The Journal of experimental medicine.

[45]  G. Holländer,et al.  Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells. , 2000, Blood.

[46]  Atsushi Mizoguchi,et al.  Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine1 , 2000, The Journal of Immunology.

[47]  M. V. D. van den Brink,et al.  IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. , 1999, The Journal of clinical investigation.

[48]  K. Matsushima,et al.  Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. , 1999, The Journal of clinical investigation.

[49]  I. Charo.  CCR2: from cloning to the creation of knockout mice. , 1999, Chemical immunology.

[50]  A. Cerwenka,et al.  Migration Kinetics and Final Destination of  Type 1 and Type 2 CD8 Effector Cells Predict Protection against Pulmonary Virus Infection , 1999, The Journal of experimental medicine.

[51]  I. Charo,et al.  Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis , 1998, Nature.

[52]  P. Allavena,et al.  Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.

[53]  R. Bravo,et al.  Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor , 1997, The Journal of experimental medicine.

[54]  Robert V Farese,et al.  Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. , 1997, The Journal of clinical investigation.

[55]  K. Ley,et al.  Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Crawford,et al.  Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. , 1997, Blood.

[57]  J. Gong,et al.  An Antagonist of Monocyte Chemoattractant Protein 1 (MCP-1) Inhibits Arthritis in the MRL-lpr Mouse Model , 1997, The Journal of experimental medicine.

[58]  J. Crawford,et al.  An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. , 1996, Blood.

[59]  E. Podack,et al.  The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice , 1996, The Journal of experimental medicine.

[60]  B. Rollins.  Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. , 1996, Molecular medicine today.

[61]  T. Springer,et al.  Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[62]  R. Salgia,et al.  Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. , 1993, Experimental hematology.

[63]  Rachel L. Mistur,et al.  Graft-Versus-Host Disease , 2016 .

[64]  G. Murphy,et al.  Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease. , 1986, The Journal of investigative dermatology.

[65]  E. Dye.  The antimetastatic function of concomitant antitumor immunity. II. Evidence that the generation of Ly-1+2+ effector T cells temporarily causes the destruction of already disseminated tumor cells. , 1986, Journal of immunology.

[66]  M. V. D. van den Brink,et al.  LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. , 2004, Blood.