Numerical study of inspiratory and expiratory flow in a human nasal cavity

The complicated architecture associated with the nasal anatomy makes it difficult for visualization and measurement of flow parameters inside the nasal cavity. Objective measurement devices like rhinomanometry or acoustic rhinometry fail to assist the understanding of the physiology at every location within the nasal cavity. Therefore, in order to visualize the flow features inside the nasal cavity and to compare the inspiratory phase and expiratory phase in terms of parameters like velocity, resistance, wall shear stress, vortex formation and turbulence intensity, a computational fluid dynamics study was carried out. This study presents, the usefulness of a technique based on functional imaging and computational fluid dynamics (CFD) modeling in generating useful data that can be used to determine and diagnose upper-airway conditions. Variations in flow patterns and flow features such as pressure drop, velocity and the left and right cavity were observed. Resistance to flow was greater during inspiratory phase when compared to the expiratory phase. Turbulence intensity was more predominant during expiratory phase, whereas vortex formation could be observed only during the inspiration mechanism.

[1]  Jianfeng Li,et al.  Numerical flow simulation in the post-endoscopic sinus surgery nasal cavity , 2008, Medical & Biological Engineering & Computing.

[2]  Shanmugam Murugappan,et al.  Validation of computational fluid dynamics methodology used for human upper airway flow simulations. , 2009, Journal of biomechanics.

[3]  David L. Swift,et al.  Nasal Deposition of Ultrafine Particles in Human Volunteers and Its Relationship to Airway Geometry , 1996 .

[4]  J. Foreman,et al.  Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine- and bradykinin-induced changes in nasal airway patency. , 1994, British journal of clinical pharmacology.

[5]  O Hilberg,et al.  Acoustic rhinometry: evaluation of nasal cavity geometry by acoustic reflection. , 1989, Journal of applied physiology.

[6]  M. M. Mozell,et al.  Numerical simulation of airflow in the human nasal cavity. , 1995, Journal of biomechanical engineering.

[7]  Mohd Zulkifly Abdullah,et al.  Airflow inside the nasal cavity: visualization using computational fluid dynamics , 2010 .

[8]  Atul Malhotra,et al.  Computational simulation of human upper airway collapse using a pressure-/state-dependent model of genioglossal muscle contraction under laminar flow conditions. , 2005, Journal of applied physiology.

[9]  Jiyuan Tu,et al.  Numerical simulations for detailed airflow dynamics in a human nasal cavity , 2008, Respiratory Physiology & Neurobiology.

[10]  Shanmugam Murugappan,et al.  Large Eddy Simulation and Reynolds-Averaged Navier-Stokes modeling of flow in a realistic pharyngeal airway model: an investigation of obstructive sleep apnea. , 2008, Journal of biomechanics.

[11]  Julia S. Kimbell,et al.  COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF INSPIRATORY AIRFLOW IN THE HUMAN NOSE AND NASOPHARYNX , 1998 .

[12]  Yingxi Liu,et al.  Numerical analysis of respiratory flow patterns within human upper airway , 2009 .

[13]  Ivo Weinhold,et al.  Numerical simulation of airflow in the human nose , 2004, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[14]  P. Cole,et al.  The site and function of the nasal valve , 1983, The Laryngoscope.

[15]  D. Wang,et al.  Acoustic rhinometric assessment of nasal obstruction after treatment with fluticasone propionate in patients with perennial rhinitis. , 2003, Auris, nasus, larynx.

[16]  M. M. Mozell,et al.  Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. , 1993, Journal of applied physiology.

[17]  R. Eccles,et al.  Errors arising in cross-sectional area estimation by acoustic rhinometry produced by breathing during measurement. , 1995, Rhinology.

[18]  Y. Jang,et al.  Measurements of cross‐sectional area of the nasal cavity by acoustic rhinometry and CT scanning , 1995, The Laryngoscope.

[19]  Vineet Rakesh,et al.  Simulation of turbulent airflow using a CT based upper airway model of a racehorse. , 2008, Journal of biomechanical engineering.

[20]  G. Kenyon Phase variation in nasal airways resistance assessed by active anterior rhinomanometry , 1987, The Journal of Laryngology & Otology.

[21]  Mohd Zulkifly Abdullah,et al.  NUMERICAL MODELLING OF A PITCHING AIRFOIL , 2010 .

[22]  J. Udupa,et al.  Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow. , 2006, Journal of biomechanics.

[23]  Jiyuan Tu,et al.  Numerical study of fibre deposition in a human nasal cavity , 2008 .

[24]  Grace M. Kepler,et al.  Effects of Differences in Nasal Anatomy on Airflow Distribution: A Comparison of Four Individuals at Rest , 2008, Annals of Biomedical Engineering.

[25]  A. Jones,et al.  Nasal airflow in inspiration and expiration , 1990, The Journal of Laryngology & Otology.