This report documents a data base and a computer program for conducting a decontamination analysis of a large, radiologically contaminated area. The data base, which was compiled largely through interviews with knowledgeable persons both in the public and private sectors, consists of the costs, physical inputs, rates and contaminant removal efficiencies of a large number of decontamination procedures. The computer program utilizes this data base along with information specific to the contaminated site to provide detailed information that includes the least costly method for effectively decontaminating each surface at the site, various types of property losses associated with the contamination, the time at which each subarea within the site should be decontaminated to minimize these property losses, the quantity of various types of labor and equipment necessary to complete the decontamination, dose to radiation workers, the costs for surveying and monitoring activities, and the disposal costs associated with radiological waste generated during cleanup. The program and data base are demonstrated with a decontamination analysis of a hypothetical site. 39 refs., 24 figs., 155 tabs.