Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations.

[1]  T. Baillie,et al.  Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions. , 1985, Journal of medicinal chemistry.

[2]  K. Chiba,et al.  Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. , 1984, Biochemical and biophysical research communications.

[3]  R. Guillery,et al.  Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion , 1984, Brain Research.

[4]  H. Yamada,et al.  Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems. , 1984, Xenobiotica; the fate of foreign compounds in biological systems.

[5]  M. Ames,et al.  High-performance liquid chromatographic resolution of enantiomers of 1-phenyl-2-aminopropanes (amphetamines) with four chiral reagents. , 1984, Journal of Chromatography A.

[6]  T. Inoue,et al.  The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) in vitro in rat. , 1983, Xenobiotica; the fate of foreign compounds in biological systems.

[7]  G. Jonsson,et al.  SELECTIVE (+)‐AMPHETAMINE NEUROTOXICITY ON STRIATAL DOPAMINE NERVE TERMINALS IN THE MOUSE , 1982, British journal of pharmacology.

[8]  M. Ames,et al.  Stereochemical aspects of para-chloroamphetamine metabolism. Rabbit liver microsomal metabolism of RS-, R(-)-. and S(+)-para-chloroamphetamine. , 1982, Biochemical pharmacology.

[9]  A. Cho,et al.  Conversion of N-hydroxyamphetamine to phenylacetone oxime by rat liver microsomes. , 1982, Biochemical pharmacology.

[10]  H. Mukhtar,et al.  Characterization of microsomal aryl hydrocarbon hydroxylase of rat brain. , 1981, The Journal of pharmacology and experimental therapeutics.

[11]  E. sanders-Bush,et al.  Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice. , 1980, European journal of pharmacology.

[12]  K. Netter Inhibition of oxidative drug metabolism in microsomes. , 1980, Pharmacology & therapeutics.

[13]  E. sanders-Bush,et al.  Long-term reduction of brain serotonin by p-chloroamphetamine: effects of inducers and inhibitors of drug metabolism. , 1978, The Journal of pharmacology and experimental therapeutics.

[14]  J. Depierre,et al.  The metabolism of polycyclic hydrocarbons and its relationship to cancer. , 1978, Biochimica et biophysica acta.

[15]  D. Wong,et al.  Importance of duration of drug action in the antagonism of p-chloroamphetamine depletion of brain serotonin-comparison of fluoxetine and chlorimipramine. , 1978, Biochemical pharmacology.

[16]  A. Y. Lu,et al.  Inhibition by CO of hepatic benzo[a]pyrene hydroxylation and its reversal by monochromatic light. , 1977, European journal of biochemistry.

[17]  J. Caldwell,et al.  The metabolism of amphetamines in mammals. , 1976, Drug metabolism reviews.

[18]  R. Fuller,et al.  Effects of intraventricuear p-chloroamphetamine and its analogues on cerebral 5-HT , 1975, Neuropharmacology.

[19]  E. sanders-Bush,et al.  Correlation between brain levels and biochemical effects of the optical isomers of p-chloroamphetamine. , 1975, The Journal of pharmacology and experimental therapeutics.

[20]  J. Harvey,et al.  P-Chloramphetamine: Selective neurotoxic action in brain. , 1975, Science.

[21]  P. Christiansen,et al.  Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in vivo: A reexamination , 1975, Neuropharmacology.

[22]  D. Jerina,et al.  Arene oxides: a new aspect of drug metabolism. , 1974, Science.

[23]  E. sanders-Bush,et al.  Action of (S)-and(R)-para-substituted amphetamine hydrochlorides and (alphaS)-and (alphaR)-p-chloronorephedrine and (alphaS)-and (alphaR)-p-chloronorpseudoephedrine hydrochlorides on the level of 5-hydroxytryptamine and the activity of tryptophan hydroxylase in rat brain. , 1974, Journal of medicinal chemistry.

[24]  E. sanders-Bush,et al.  p-Chloroamphetamine--inhibition of cerebral tryptophan hydroxylase. , 1972, Biochemical pharmacology.

[25]  W. Burkard,et al.  Aralkylamines with different effects on the metabolism of aromatic monoamines. , 1966, The Journal of pharmacology and experimental therapeutics.

[26]  R. Fuller,et al.  LOWERING OF BRAIN SEROTONIN LEVEL BY CHLORAMPHETAMINES. , 1965, Biochemical pharmacology.

[27]  W. Burkard,et al.  CHLORINATED ARYLALKYLAMINES AFFECTING THE CEREBRAL METABOLISM OF 5-HYDROXYTRYPTAMINE. , 1964, The Journal of pharmacology and experimental therapeutics.

[28]  P. Siekevitz,et al.  ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER , 1962, The Journal of cell biology.

[29]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.