Effect of GABAergic drugs on dopamine catabolism in the nigrostriatal and mesolimbic dopaminergic pathways of the rat

studies. The contralateral hypotensive effect in the untreated fellow eye in our hypertensive subjects has been documented in animals (Green et al 1978) and suggests that the pressure lowering effect of A@-THC is through systemic (cardiovascular andlor central nervous) rather than locally mediated effects within the eye. Before the full therapeutic potential of the cannabinoids are realized, further research should identify the ocularactive cannabinoid which would have minimal cardiovascular and psychologic effects so that local delivery systems of this cannabinoid may be devised. REFERENCES

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