Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury.

[1]  R. Savino,et al.  Interleukin 6 is important for survival after partial hepatectomy in mice , 2003, Hepatology.

[2]  M. Kusano,et al.  Anti-transforming growth factor-beta1 antibody improves survival rate following partial hepatectomy in cirrhotic rats. , 2002, Hepatology research : the official journal of the Japan Society of Hepatology.

[3]  Kerstin Krieglstein,et al.  Mechanisms of TGF-β-mediated apoptosis , 2001, Cell and Tissue Research.

[4]  M. Benito,et al.  Epidermal Growth Factor Impairs the Cytochrome C/Caspase‐3 Apoptotic Pathway Induced by Transforming Growth Factor β in Rat Fetal Hepatocytes Via a Phosphoinositide 3‐Kinase–Dependent Pathway , 2000 .

[5]  T. Ueno,et al.  Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine‐treated rats , 2000, Hepatology.

[6]  K. L. Pierce,et al.  Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells* , 2000, The Journal of Biological Chemistry.

[7]  T. Nakamura,et al.  Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats. , 2000, International journal of oncology.

[8]  D. Stolz,et al.  Expression and activation of pro‐MMP‐2 and pro‐MMP‐9 during rat liver regeneration , 2000, Hepatology.

[9]  S. Masson,et al.  Changes in growth factor and cytokine mRNA levels after hepatectomy in rat with CCl4-induced cirrhosis. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[10]  P. Clavien,et al.  Ischemia impairs liver regeneration after major tissue loss in rodents: Protective effects of interleukin‐6 , 1999, Hepatology.

[11]  T. Neuman,et al.  Transforming growth factor beta1 helps maintain differentiated functions in mitogen-treated primary rat hepatocyte cultures. , 1999, Molecular cell biology research communications : MCBRC.

[12]  M. Arvigo,et al.  IGF-I production by adult rat hepatocytes is stimulated by transforming growth factor-alpha and transforming growth factor-beta1. , 1999, European journal of endocrinology.

[13]  J. Winer,et al.  Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. , 1999, Analytical biochemistry.

[14]  A. Ooshima,et al.  Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Demetris,et al.  Mitosis and apoptosis in the liver of interleukin‐6–deficient mice after partial hepatectomy , 1999, Hepatology.

[16]  Y. Kaneda,et al.  Hepatocyte growth factor gene therapy of liver cirrhosis in rats , 1999, Nature Medicine.

[17]  J. Lebreton,et al.  Cytokine gene expression in liver following minor or major hepatectomy in rat. , 1997, Cytokine.

[18]  J. Jansson,et al.  Insulin-Like Growth Factors Stimulate Expression of Hepatocyte Growth Factor But Not Transforming Growth Factor β1 in Cultured Hepatic Stellate Cells. , 1997, Endocrinology.

[19]  P. Desmond,et al.  Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor β in a bile duct ligated rat model of cirrhosis , 1997, Hepatology.

[20]  D. Stolz,et al.  Modifications of the hepatocyte growth factor/c‐met pathway by constitutive expression of transforming growth factor‐α in rat liver epithelial cells , 1997, Molecular carcinogenesis.

[21]  J. Peschon,et al.  Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  G. Michalopoulos,et al.  Liver Regeneration , 1997, Science.

[23]  E. Furth,et al.  Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice , 1996, Science.

[24]  K. Livak,et al.  Real time quantitative PCR. , 1996, Genome research.

[25]  C. Heid,et al.  A novel method for real time quantitative RT-PCR. , 1996, Genome research.

[26]  A. Ooshima,et al.  Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-β (TGF-β) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-β in Vascular Wall Cells in Primary Culture* , 1996, The Journal of Biological Chemistry.

[27]  Gressner Am.  Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. , 1996 .

[28]  M. Benito,et al.  Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor‐beta in fetal hepatocytes in primary culture , 1996, FEBS letters.

[29]  Y. Kanegae,et al.  Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  H. Wakimoto,et al.  Immunohistochemical detection of Ki-67 in replicative smooth muscle cells of rabbit carotid arteries after balloon denudation. , 1995, Stroke.

[31]  A. Takeshita,et al.  Quantitative analysis of repeat adenovirus-mediated gene transfer into injured canine femoral arteries. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[32]  N. Fausto,et al.  Role of growth factors and cytokines in hepatic regeneration , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  A. Gressner,et al.  Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells , 1995, Hepatology.

[34]  G. Michalopoulos,et al.  The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis , 1995, The Journal of cell biology.

[35]  D. Clemmons,et al.  Insulin-like growth factors and their binding proteins: biological actions. , 1995, Endocrine reviews.

[36]  Michalopoulos Gk.  HGF in liver regeneration and tumor promotion. , 1995 .

[37]  Gressner Am.  Cytokines and cellular crosstalk involved in the activation of fat-storing cells. , 1995 .

[38]  M. Pinzani.  Novel insights into the biology and physiology of the Ito cell. , 1995, Pharmacology & therapeutics.

[39]  A. Gressner,et al.  Hepatocyte-conditioned medium potentiates insulin-like growth factor (IGF) 1 and 2 stimulated DNA synthesis of cultured fat storing cells. , 2008, Liver.

[40]  N. Fausto,et al.  Transforming growth factor‐α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor‐α and hepatocyte growth factor , 1993 .

[41]  G. Michalopoulos,et al.  Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. , 1993, The American journal of pathology.

[42]  A. Gressner,et al.  The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture. , 1993, Journal of hepatology.

[43]  R. Schulte‐Hermann,et al.  Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-beta 1 occurs without activation of an endonuclease. , 1992, Toxicology letters.

[44]  F. Minuto,et al.  Effect of epidermal growth factor on insulin-like growth factor-I (IGF-I) and IGF-binding protein synthesis by adult rat hepatocytes , 1992, Molecular and Cellular Endocrinology.

[45]  Yamamura Ken-ichi,et al.  Efficient selection for high-expression transfectants with a novel eukaryotic vector , 1991 .

[46]  H. Niwa,et al.  Efficient selection for high-expression transfectants with a novel eukaryotic vector. , 1991, Gene.

[47]  M. De Marchis,et al.  Expression of hepatic mRNAs for insulin-like growth factors-I and -II during the development of hypothyroid rats. , 1991, The Journal of endocrinology.

[48]  R. Blomhoff,et al.  Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  K. Gatter,et al.  Monoclonal antibody Ki‐67: its use in histopathology , 1990, Histopathology.

[50]  D. Aron,et al.  Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: regulatory role of platelet-derived growth factor. , 1990, Endocrinology.

[51]  H. Tsubouchi,et al.  Biological and immunological properties of human hepatocyte growth factor from plasma of patients with fulminant hepatic failure. , 1990, Biochimica et biophysica acta.

[52]  R. Humbel,et al.  Insulin-like growth factors I and II. , 1990, European journal of biochemistry.

[53]  T. Unterman,et al.  Different tissue distribution and hormonal regulation of messenger RNAs encoding rat insulin-like growth factor-binding proteins-1 and -2. , 1990, Molecular endocrinology.

[54]  J. Mead,et al.  Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[55]  P. Rotwein,et al.  Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. , 1989, Endocrine reviews.

[56]  R. Coffey,et al.  Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[57]  J. Poulos,et al.  Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver. , 1988, The Journal of clinical investigation.

[58]  B. Moats-Staats,et al.  Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues. , 1986, The Journal of biological chemistry.

[59]  H. Moses,et al.  Inhibition of DNA Synthesis in rat hepatocytes by Platelet-derived Type β Transforming Growth Factor , 1986 .

[60]  B. Draznin,et al.  Role of the liver in regulating somatomedin activity: hormonal effects on the synthesis and release of insulin-like growth factor and its carrier protein by the isolated perfused rat liver. , 1979, Endocrinology.