Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography-tandem mass spectrometry.

[1]  L. Dember.  Modern treatment of amyloidosis: unresolved questions. , 2009, Journal of the American Society of Nephrology : JASN.

[2]  R. Petersen,et al.  Isolated Limb Infusion for In-Transit Malignant Melanoma of the Extremity: A Well-Tolerated but Less Effective Alternative to Hyperthermic Isolated Limb Perfusion , 2008, Annals of Surgical Oncology.

[3]  P. Sugarbaker,et al.  Pharmacokinetic and phase II study of heated intraoperative intraperitoneal melphalan , 2006, Cancer Chemotherapy and Pharmacology.

[4]  P. Mouncey,et al.  Trials in advanced Hodgkin's disease: more than 30 years experience of the British National Lymphoma Investigation. , 2004, Clinical lymphoma.

[5]  J. Schellens,et al.  Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue. , 2003, Biomedical chromatography : BMC.

[6]  D. Fraker,et al.  A human melanoma xenograft in a nude rat responds to isolated limb perfusion with TNF plus melphalan. , 2003, Surgery.

[7]  F. Brion,et al.  Separation methods for alkylating antineoplastic compounds. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[8]  R. Causon,et al.  Rapid determination of the anti-cancer drug Melphalan (AlkeranTM) in human serum and plasma by automated solid phase extraction and liquid chromatography tandem mass spectrometry , 2000 .

[9]  A. Buschauer,et al.  A versatile high-performance liquid chromatography method for the measurement of melphalan tailored to the optimization of hyperthermic isolated limb perfusion , 1997 .

[10]  J. M. Joulia,et al.  High-performance liquid chromatographic assay for melphalan in human plasma. Application to pharmacokinetic studies. , 1996, Journal of chromatography. B, Biomedical applications.

[11]  G. R. Cannell,et al.  High-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions. , 1995, Journal of chromatography. B, Biomedical applications.

[12]  D. Noe,et al.  Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione. , 1993, Drug metabolism and disposition: the biological fate of chemicals.

[13]  C. Baiocchi,et al.  Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection. , 1991, Journal of chromatography.

[14]  F. Borella,et al.  High-performance liquid chromatographic determination of m-bis(chloroethyl)aminophenyl-L-alanine in plasma. , 1989, Journal of chromatography.

[15]  J. Crawhall,et al.  Determination of melphalan in the perfusate from patients treated by regional perfusion chemotherapy. , 1987, Journal of pharmaceutical and biomedical analysis.

[16]  S. Eksborg,et al.  Quantitative determination of melphalan in plasma by liquid chromatography after derivatization with N-acetylcysteine. , 1986, Journal of chromatography.

[17]  N. Greig,et al.  High-performance liquid chromatographic analysis of melphalan in plasma, brain and peripheral tissue by o-phthalaldehyde derivatization and fluorescence detection. , 1985, Journal of chromatography.

[18]  D. Burns,et al.  Modified extraction and chromatography for the measurement of plasma melphalan by ion-pair high-performance liquid chromatography. , 1984, Journal of chromatography.

[19]  A. G. Bosanquet,et al.  Measurement of plasma melphalan at therapeutic concentrations using isocratic high-performance liquid chromatography. , 1982, Journal of chromatography.

[20]  A. E. Ahmed,et al.  Quantitative analysis of melphalan and its major hydrolysate in patients and animals by reversed-phase high-performance liquid chromatography. , 1981, Journal of chromatography.

[21]  H. Mukhtar,et al.  The postnatal development of microsomal expoxide hydrase, cytosolic glutathione S-transferase, and mitochondrial and microsomal cytochrome P-450 in adrenals and ovaries of female rats. , 1978, Drug metabolism and disposition: the biological fate of chemicals.