MULT İPLE SCLEROS İS AND AMALGAM

Amalgams is still used today as a restorative mater ial. Due to mercury inside, amalgam used in restora tive dental has always been the subject of debate. Studies have bee n performed on mercury in terms of norotoksikoloji. However, the effects of mercury on the nervous system has no t been clarified. Microleakage of mercury comes out of amalgam and this mercury can pass through the blood brain b arrier. A portion of the authors in their study sta ted that microleakage of mercury can be tolerated; while oth ers pointed out that microleakage of mercury can no t be tolerated. However; mercury which penetrates the bo dy is located in the etiology of diseases such as A lzheimer, chronic fatigue, and multiple sclerosis (MS). In th is paper, it has been described that whether there is a relationship between MS and amalgam restorative materials.

[1]  J. Bartova,et al.  Dental amalgam as one of the risk factors in autoimmune diseases. , 2003, Neuro endocrinology letters.

[2]  M. Shamy,et al.  Neuroimmunotoxicology: humoral assessment of neurotoxicity and autoimmune mechanisms. , 1999, Environmental health perspectives.

[3]  Hans Lassmann,et al.  Pathology and pathogenesis of demyelinating diseases , 1997, Current opinion in neurology.

[4]  W. Hemmer,et al.  Patch test reactions in children, adults and the elderly, A comparative study in patients with suspected allergic contact dermatitis , 1996, Contact dermatitis.

[5]  K. Rosenman,et al.  Peripheral neurotoxicity in workers exposed to inorganic mercury compounds. , 1987, Archives of environmental health.

[6]  T. Balazs.  Immunogenetically Controlled Autoimmune Reactions Induced by Mercury, Gold and D-Penicillamine in Laboratory Animals: a Review from the Vantage Point of Premarketing Safety Studies , 1987, Toxicology and industrial health.

[7]  P. Knoflach,et al.  Autoimmune Disease Induced by Oral Administration of Mercuric Chloride in Brown-Norway Rats , 1986, Toxicologic pathology.

[8]  D. Eggleston,et al.  Effect of dental amalgam and nickel alloys on T-lymphocytes: preliminary report. , 1984, The Journal of prosthetic dentistry.

[9]  T. Ingalls.  Epidemiology, etiology, and prevention of multiple sclerosis: Hypothesis and fact , 1983, The American journal of forensic medicine and pathology.

[10]  J. Weening,et al.  Demonstration of antinuclear antibodies in mercuric chloride-induced glomerulopathy in the rat. , 1978, Laboratory investigation; a journal of technical methods and pathology.

[11]  L. Chang,et al.  Neurotoxic effects of mercury--a review. , 1977, Environmental research.

[12]  P. Druet,et al.  Mercuric chloride‐induced anti‐glomerular basement membrane antibodies in the rat Genetic control , 1977, European journal of immunology.

[13]  Ivan Sterzl,et al.  Mercury and nickel allergy: risk factors in fatigue and autoimmunity. , 1999, Neuro endocrinology letters.

[14]  R. Siblerud,et al.  A COMPARISON OF ORAL HEALTH BETWEEN MULTIPLE SCLEROSIS SUBJECTS WITH DENTAL AMALGAMS AND THOSE WITH AMALGAMS REMOVED , 1999 .

[15]  G. Dean.  How many people in the world have multiple sclerosis? , 1994, Neuroepidemiology.