Interdisciplinary perspectives on the development, integration, and application of cognitive ontologies

We discuss recent progress in the development of cognitive ontologies and summarize three challenges in the coordinated development and application of these resources. Challenge 1 is to adopt a standardized definition for cognitive processes. We describe three possibilities and recommend one that is consistent with the standard view in cognitive and biomedical sciences. Challenge 2 is harmonization. Gaps and conflicts in representation must be resolved so that these resources can be combined for mark-up and interpretation of multi-modal data. Finally, Challenge 3 is to test the utility of these resources for large-scale annotation of data, search and query, and knowledge discovery and integration. As term definitions are tested and revised, harmonization should enable coordinated updates across ontologies. However, the true test of these definitions will be in their community-wide adoption which will test whether they support valid inferences about psychological and neuroscientific data.

[1]  Giulio Tononi,et al.  A Proposal for a Decade of the Mind Initiative , 2007, Science.

[2]  Robert Frank,et al.  Minimal Information for Neural Electromagnetic Ontologies (MINEMO): A standards-compliant method for analysis and integration of event-related potentials (ERP) data , 2011, Standards in genomic sciences.

[3]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[4]  Angela R. Laird,et al.  Lost in localization? The focus is meta-analysis , 2009, NeuroImage.

[5]  Yanjue Wu,et al.  Transgenic C. elegans as a model in Alzheimer's research. , 2005, Current Alzheimer research.

[6]  Hans-Michael Müller,et al.  The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience , 2008, Neuroinformatics.

[7]  Su Guo,et al.  Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes , 2010, Neurobiology of Disease.

[8]  John F. Cryan,et al.  Model organisms: The ascent of mouse: advances in modelling human depression and anxiety , 2005, Nature Reviews Drug Discovery.

[9]  D. Spalding The Principles of Psychology , 1873, Nature.

[10]  Dejing Dou,et al.  Development of Neural Electromagnetic Ontologies (NEMO): Ontology-based Tools for Representation and Integration of Event-related Brain Potentials , 2009 .

[11]  D. V. van Essen,et al.  Challenges and Opportunities in Mining Neuroscience Data , 2011, Science.

[12]  Christopher G. Chute,et al.  BioPortal: ontologies and integrated data resources at the click of a mouse , 2009, Nucleic Acids Res..

[13]  M. Ashburner,et al.  The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration , 2007, Nature Biotechnology.

[14]  Barry Smith,et al.  The Cornucopia of Formal-Ontological Relations , 2005 .

[15]  William D. Duncan,et al.  The neurological disease ontology , 2013, J. Biomed. Semant..

[16]  Anders M. Dale,et al.  The Challenge of Connecting the Dots in the B.R.A.I.N. , 2013, Neuron.

[17]  Russell A. Poldrack,et al.  Discovering Relations Between Mind, Brain, and Mental Disorders Using Topic Mapping , 2012, PLoS Comput. Biol..

[18]  E G Jones,et al.  Assessing the Decade of the Brain , 1999, Science.

[19]  José L. V. Mejino,et al.  A reference ontology for biomedical informatics: the Foundational Model of Anatomy , 2003, J. Biomed. Informatics.

[20]  Jessica A. Turner,et al.  The Cognitive Paradigm Ontology: Design and Application , 2011, Neuroinformatics.

[21]  Werner Ceusters,et al.  Foundations for a realist ontology of mental disease , 2010, J. Biomed. Semant..

[22]  R. Cabeza,et al.  Frontiers in Human Neuroscience , 2009 .

[23]  Eric R. Kandel Book Review: Psychiatry, Psychoanalysis and the New Biology of Mind , 2005 .

[24]  Barry Smith,et al.  A relational theory of the act , 1986 .

[25]  Amarnath Gupta,et al.  Development and use of Ontologies Inside the Neuroscience Information Framework: A Practical Approach , 2012, Front. Gene..

[26]  Herbert S. Gross,et al.  Psychiatry, Psychoanalysis and the New Biology of Mind , 2006 .

[27]  Klaus Fliessbach,et al.  Differential effects of semantic processing on memory encoding , 2010, Human brain mapping.

[28]  Jean Decety,et al.  Frontiers in Human Neuroscience: The Golden Triangle and Beyond , 2010, Perspectives on psychological science : a journal of the Association for Psychological Science.

[29]  L. Weyandt,et al.  The Physiological Bases of Cognitive and Behavioral Disorders , 2005 .

[30]  Mark Jensen,et al.  Measuring Cognitive Functions: Hurdles in the Development of the NeuroPsychological Testing Ontology , 2013, ICBO.

[31]  Aniket Kittur,et al.  The Cognitive Atlas: Toward a Knowledge Foundation for Cognitive Neuroscience , 2011, Front. Neuroinform..

[32]  J. Tait,et al.  Challenges and opportunities. , 1996, Journal of psychiatric and mental health nursing.

[33]  Paea LePendu,et al.  Ontology-Based Analysis of Event-Related Potentials , 2011, ICBO.

[34]  Angela R. Laird,et al.  BrainMap , 2007, Neuroinformatics.

[35]  Karl J. Friston,et al.  Distributed processing; distributed functions? , 2012, NeuroImage.

[36]  Werner Ceusters,et al.  Wanting what we don't want to want: Representing addiction in interoperable bio-ontologies , 2012, ICBO.

[37]  Stefan Schulz,et al.  Ontologies for human behavior analysis and their application to clinical data. , 2012, International review of neurobiology.

[38]  Jessica A. Turner,et al.  Modeling biomedical experimental processes with OBI , 2010, J. Biomed. Semant..

[39]  Jessica A. Turner,et al.  Modeling functional Magnetic Resonance Imaging (fMRI) experimental variables in the Ontology of Experimental Variables and Values (OoEVV) , 2013, NeuroImage.

[40]  John A. Stankovic,et al.  Distributed Processing , 1978, Computer.

[41]  Werner Ceusters,et al.  Ontological realism: A methodology for coordinated evolution of scientific ontologies , 2010, Appl. Ontology.

[42]  Gwen A. Frishkoff,et al.  Mental Functioning is Neural Functioning : Towards a Unified Ontology of Mind , Brain , and Behavior , 2012 .

[43]  D. S. Parker,et al.  Cognitive ontologies for neuropsychiatric phenomics research , 2009, Cognitive neuropsychiatry.

[44]  Eric S. Raymond,et al.  The Cathedral and the Bazaar , 2000 .

[45]  Robert Hoehndorf,et al.  The neurobehavior ontology: an ontology for annotation and integration of behavior and behavioral phenotypes. , 2012, International review of neurobiology.