MicroRNAs in mouse models of lymphoid malignancies.

The discovery of microRNAs (miRNAs) has revealed a new layer of gene expression regulation that affects many normal and pathologic biological systems. Among the malignancies affected by the dysregulation of miRNAs there are cancers of lymphoid origin, in which miRNAs are thought to have tumor suppressive or tumor promoting activities, depending on the nature of their specific targets. In the last 4-5 years, the experimental field that provided the deepest insights into the in vivo biology of miRNAs is that of mouse modeling in which transgenic and knockout animals mimic, respectively, over-expression or down-regulation of specific miRNAs involved in human leukemia/lymphoma. This review discusses recent advances in our understanding of lymphoid malignancies based on the natural and engineered mouse models of three different miRNAs, miR-15a/16-1 cluster, miR-155, and miR-17-92 cluster.

[1]  Y. Pekarsky,et al.  CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation , 2010, Leukemia.

[2]  Ryan M. O’Connell,et al.  Physiological and pathological roles for microRNAs in the immune system , 2010, Nature Reviews Immunology.

[3]  Andrea Califano,et al.  The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. , 2010, Cancer cell.

[4]  Doron Betel,et al.  Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. , 2009, Genes & development.

[5]  S. Lowe,et al.  miR-19 is a key oncogenic component of mir-17-92. , 2009, Genes & development.

[6]  C. Croce.  Causes and consequences of microRNA dysregulation in cancer , 2009, Nature Reviews Genetics.

[7]  G. Marti,et al.  Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity , 2009, Molecular Cancer Therapeutics.

[8]  C. Croce,et al.  Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. , 2009, Blood.

[9]  Ryan M. O’Connell,et al.  Inositol phosphatase SHIP1 is a primary target of miR-155 , 2009, Proceedings of the National Academy of Sciences.

[10]  Hua Zhang,et al.  New insight into the role of miRNAs in leukemia , 2009, Science in China Series C: Life Sciences.

[11]  C. Croce,et al.  MicroRNAs in the ontogeny of leukemias and lymphomas , 2009, Leukemia & lymphoma.

[12]  C. Croce,et al.  miR-155: On the Crosstalk Between Inflammation and Cancer , 2009, International reviews of immunology.

[13]  C. Croce,et al.  MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis , 2008, Proceedings of the National Academy of Sciences.

[14]  Torsten Haferlach,et al.  Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin , 2008, Proceedings of the National Academy of Sciences.

[15]  Aadel A. Chaudhuri,et al.  Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder , 2008, The Journal of experimental medicine.

[16]  Jing Wang,et al.  Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes , 2008, Nature Immunology.

[17]  G. Marti,et al.  Murine models of chronic lymphocytic leukaemia: role of microRNA‐16 in the New Zealand Black mouse model , 2007, British journal of haematology.

[18]  M. Fabbri,et al.  Regulatory mechanisms of microRNAs involvement in cancer , 2007, Expert opinion on biological therapy.

[19]  Pablo Landgraf,et al.  Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. , 2007, Blood.

[20]  N. Rajewsky,et al.  Regulation of the Germinal Center Response by MicroRNA-155 , 2007, Science.

[21]  Anton J. Enright,et al.  Requirement of bic/microRNA-155 for Normal Immune Function , 2007, Science.

[22]  Y. Pekarsky,et al.  Animal models for chronic lymphocytic leukemia , 2007, Journal of cellular biochemistry.

[23]  C. Croce,et al.  Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. , 2006, Seminars in oncology.

[24]  C. Croce,et al.  A microRNA expression signature of human solid tumors defines cancer gene targets , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Stefano Volinia,et al.  Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice. , 2006, Cancer research.

[26]  Muller Fabbri,et al.  A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. , 2005, The New England journal of medicine.

[27]  A. van den Berg,et al.  BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas , 2005, The Journal of pathology.

[28]  C. Croce,et al.  miR-15 and miR-16 induce apoptosis by targeting BCL2. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Lowe,et al.  A microRNA polycistron as a potential human oncogene , 2005, Nature.

[30]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[31]  Wayne Tam,et al.  Accumulation of miR-155 and BIC RNA in human B cell lymphomas. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Hendrik Witt,et al.  Preface , 2004, Molecular and Cellular Endocrinology.

[33]  C. Croce,et al.  MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[35]  C. Croce,et al.  Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[36]  C. Croce,et al.  Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Y. Pekarsky,et al.  Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. , 2001, Cancer research.

[38]  Minchen Chien,et al.  Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. , 2001, Blood.

[39]  G. Krystal,et al.  A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity , 2000, The Journal of experimental medicine.

[40]  J. Penninger,et al.  The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling , 1998, The Journal of experimental medicine.

[41]  E. Zabarovsky,et al.  Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia. , 1998, Blood.

[42]  E. Zabarovsky,et al.  Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia , 1997, Oncogene.

[43]  W. S. Hayward,et al.  bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA , 1997, Molecular and cellular biology.

[44]  D. Sherr,et al.  A cultured malignant B-1 line serves as a model for Richter's syndrome. , 1994, Journal of immunology.

[45]  C. Trautwein,et al.  Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain , 1993, Nature.

[46]  S. Akira,et al.  Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. , 1992, Blood.

[47]  E. Raveche,et al.  Possible immunoregulatory role for CD5 + B cells. , 1990, Clinical immunology and immunopathology.

[48]  W. S. Hayward,et al.  Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events , 1989, Molecular and cellular biology.

[49]  Stefano Volinia,et al.  Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.