The impact of translocations and gene fusions on cancer causation

[1]  T. Haferlach,et al.  Monitoring of minimal residual disease in acute myeloid leukemia , 2005, Cancer.

[2]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[3]  L. Ricci-Vitiani,et al.  Identification and expansion of human colon-cancer-initiating cells , 2007, Nature.

[4]  G. Jenster,et al.  TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer. , 2006, Cancer research.

[5]  O. Kallioniemi,et al.  TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. , 2006, Cancer research.

[6]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[7]  R. Henrique,et al.  TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. , 2006, Neoplasia.

[8]  J. Rowley,et al.  Chromatin structural elements and chromosomal translocations in leukemia. , 2006, DNA repair.

[9]  L. Povirk Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks. , 2006, DNA repair.

[10]  I. Panagopoulos,et al.  Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer. , 2006, Genes, chromosomes & cancer.

[11]  Michael Ittmann,et al.  Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer. , 2006, Cancer research.

[12]  J. Tchinda,et al.  TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. , 2006, Cancer research.

[13]  Nicolò Riggi,et al.  Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. , 2006, Cancer research.

[14]  T. Triche,et al.  Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas. , 2006, Cancer research.

[15]  I. Panagopoulos,et al.  Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer , 2006 .

[16]  Thomas Cremer,et al.  Chromosome territories--a functional nuclear landscape. , 2006, Current opinion in cell biology.

[17]  A. Evans,et al.  Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. , 2006, Neoplasia.

[18]  Farin Kamangar,et al.  Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  M. Lieber,et al.  DNA structures at chromosomal translocation sites. , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

[20]  A. Tomaszewska,et al.  [Chromosome instability syndromes]. , 2006, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.

[21]  L. Szekely,et al.  Molecular classification of mucoepidermoid carcinomas—Prognostic significance of the MECT1–MAML2 fusion oncogene , 2006, Genes, chromosomes & cancer.

[22]  M. D. Boer,et al.  The MLL recombinome of acute leukemias , 2006, Leukemia.

[23]  Ioannis Panagopoulos,et al.  Fusion of ETV6 with an intronic sequence of the BAZ2A gene in a paediatric pre‐B acute lymphoblastic leukaemia with a cryptic chromosome 12 rearrangement , 2006, British journal of haematology.

[24]  M. Höglund,et al.  A gene fusion network in human neoplasia , 2006, Oncogene.

[25]  F. J. Novo,et al.  Chromosome translocations in cancer: computational evidence for the random generation of double-strand breaks. , 2006, Trends in genetics : TIG.

[26]  Arul M Chinnaiyan,et al.  TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. , 2006, Cancer research.

[27]  S. Ogston,et al.  Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia , 2006, Leukemia.

[28]  C. Tribioli,et al.  Leukemia with distinct phenotypes in transgenic mice expressing PML/RARα, PLZF/RARα or NPM/RARα , 2006, Oncogene.

[29]  O. Heidenreich,et al.  Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials , 2006, Acta Pharmacologica Sinica.

[30]  F. Speleman,et al.  Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements , 2006, Leukemia.

[31]  Robert J. Marinelli,et al.  A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[32]  K. Theil,et al.  Frequencies and characterization of cytogenetically unrelated clones in various hematologic malignancies: seven years of experiences in a single institution. , 2006, Cancer genetics and cytogenetics.

[33]  C. Antonescu The role of genetic testing in soft tissue sarcoma , 2006, Histopathology.

[34]  Recurrent Fusion of TMPRSS 2 and ETS Transcription Factor Genes in Prostate Cancer , 2006 .

[35]  P. Aplan,et al.  Causes of oncogenic chromosomal translocation. , 2006, Trends in genetics : TIG.

[36]  Patrik Edén,et al.  Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Ralf Janknecht,et al.  EWS-ETS oncoproteins: the linchpins of Ewing tumors. , 2005, Gene.

[38]  A. Trumpp,et al.  Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. , 2005, Cancer research.

[39]  F. Barr,et al.  Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors. , 2005, European journal of cancer.

[40]  J. Tchinda,et al.  Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer , 2005, Science.

[41]  Michael R. Speicher,et al.  The new cytogenetics: blurring the boundaries with molecular biology , 2005, Nature Reviews Genetics.

[42]  A. Poustka,et al.  Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. , 2005, Cancer research.

[43]  J. Dick,et al.  Cancer stem cells: lessons from leukemia. , 2005, Trends in cell biology.

[44]  B. Johansson,et al.  Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders , 2005, Genes, chromosomes & cancer.

[45]  L. Kearney,et al.  Molecular cytogenetics in haematological malignancy: current technology and future prospects , 2005, Chromosoma.

[46]  T. Jacks,et al.  Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer , 2005, Cell.

[47]  S. Bohlander ETV6: a versatile player in leukemogenesis. , 2005, Seminars in cancer biology.

[48]  P. Sorensen,et al.  ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. , 2005, Seminars in cancer biology.

[49]  K. Anderson,et al.  Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia , 2005, Nature Medicine.

[50]  D. Pinkel,et al.  Array comparative genomic hybridization and its applications in cancer , 2005, Nature Genetics.

[51]  J. Fletcher,et al.  Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes , 2005, Oncogene.

[52]  Tom Misteli,et al.  Concepts in nuclear architecture , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[53]  M. Segal,et al.  DNA topoisomerase II in therapy-related acute promyelocytic leukemia. , 2005, The New England journal of medicine.

[54]  D. Gilliland,et al.  Leukaemia stem cells and the evolution of cancer-stem-cell research , 2005, Nature Reviews Cancer.

[55]  Ralf Küppers,et al.  Mechanisms of B-cell lymphoma pathogenesis , 2005, Nature Reviews Cancer.

[56]  B. Druker,et al.  Oncogenes and Tumor Suppressors (795 articles) , 2004 .

[57]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[58]  R. Pieters,et al.  Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells. , 2005, Cancer research.

[59]  R. Pieters,et al.  Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[60]  W. Hiddemann,et al.  Population-based age-specific incidences of cytogenetic subgroups of acute myeloid leukemia. , 2005, Haematologica.

[61]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[62]  F. Lo‐Coco,et al.  A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia , 2004, Genes, chromosomes & cancer.

[63]  C. Antonescu,et al.  Midline carcinoma of children and young adults with NUT rearrangement. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[64]  A. Ferrando,et al.  Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia , 2004, Nature Genetics.

[65]  K. Kinzler,et al.  Cancer genes and the pathways they control , 2004, Nature Medicine.

[66]  J. Fletcher,et al.  Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12). , 2004, The American journal of pathology.

[67]  B. Johansson,et al.  Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer , 2004, Nature Genetics.

[68]  I. Yaniv,et al.  The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors , 2004, Cancer.

[69]  T. Hubbard,et al.  A census of human cancer genes , 2004, Nature Reviews Cancer.

[70]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[71]  B. Johansson,et al.  Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia , 2004, Annals of medicine.

[72]  C. Bloomfield,et al.  Cytogenetics in Acute Leukemia , 2022 .

[73]  D. Gilliland,et al.  CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. , 2003, Blood.

[74]  J. Radich,et al.  Monitoring bcr-abl by polymerase chain reaction in the treatment of chronic myeloid leukemia , 2003, Current oncology reports.

[75]  M. Greaves,et al.  Origins of chromosome translocations in childhood leukaemia , 2003, Nature Reviews Cancer.

[76]  Tom Misteli,et al.  Spatial proximity of translocation-prone gene loci in human lymphomas , 2003, Nature Genetics.

[77]  Jen-Fen Fu,et al.  Identification of CBL, a proto‐oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia , 2003, Genes, chromosomes & cancer.

[78]  P. Meltzer,et al.  Soft tissue sarcomas of adults: state of the translational science. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[79]  Keara M. Lane,et al.  Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21) , 2003, Genes, chromosomes & cancer.

[80]  F. Pedeutour,et al.  Genetics of dermatofibrosarcoma protuberans family of tumors: From ring chromosomes to tyrosine kinase inhibitor treatment , 2003, Genes, chromosomes & cancer.

[81]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[82]  M. Potter,et al.  Lymphoma‐ and leukemia‐associated chromosomal translocations in healthy individuals , 2003, Genes, chromosomes & cancer.

[83]  N. Nowak,et al.  High-resolution analysis of genetic events in cancer cells using bacterial artificial chromosome arrays and comparative genome hybridization. , 2003, Advances in cancer research.

[84]  D. Gilliland,et al.  Genetics of myeloid leukemias. , 2003, Annual review of genomics and human genetics.

[85]  B. Johansson,et al.  Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976–1993 and on 5098 unselected cases reported in the literature 1974–2001 , 2002, Leukemia.

[86]  F. Bertucci,et al.  Reciprocal translocations in breast tumor cell lines: Cloning of a t(3;20) that targets the FHIT gene , 2002, Genes, chromosomes & cancer.

[87]  P. Pandolfi,et al.  Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders? , 2002, Trends in molecular medicine.

[88]  P. Nowell Tumor progression: a brief historical perspective. , 2002, Seminars in cancer biology.

[89]  P. Pfeiffer,et al.  Chromosomal aberrations: formation, identification and distribution. , 2002, Mutation research.

[90]  L. Foroni,et al.  Cytogenetics and molecular genetics of acute lymphoblastic leukemia. , 2002, Reviews in clinical and experimental hematology.

[91]  M. Andersen,et al.  Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. , 2002, Blood.

[92]  B. Johansson,et al.  Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia , 2002, Acta Haematologica.

[93]  J. Downing,et al.  Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. , 2002, Cancer cell.

[94]  J. Downing,et al.  Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. , 2002, Cancer cell.

[95]  J. Downing,et al.  Expression of a conditional AML 1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t ( 8 ; 21 ) acute myeloid leukemia , 2002 .

[96]  J. Rowley,et al.  Chromosome translocations: dangerous liaisons revisited , 2001, Nature Reviews Cancer.

[97]  P. A. Pérez-Mancera,et al.  Selective destruction of tumor cells through specific inhibition of products resulting from chromosomal translocations. , 2001, Current cancer drug targets.

[98]  J. Squire,et al.  Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. , 2001, Blood.

[99]  M. Pierotti Chromosomal rearrangements in thyroid carcinomas: a recombination or death dilemma. , 2001, Cancer letters.

[100]  Alfons Meindl,et al.  The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 , 2001, Oncogene.

[101]  J. Melo,et al.  The molecular biology of chronic myeloid leukemia. , 2000, Blood.

[102]  M. Nikiforova,et al.  Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. , 2000, Science.

[103]  M. K. Hibbard,et al.  PLAG1 fusion oncogenes in lipoblastoma. , 2000, Cancer research.

[104]  T. Flores,et al.  The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice , 2000, Oncogene.

[105]  H. Rabes,et al.  Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[106]  M. Caligiuri,et al.  Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Leversha,et al.  Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia. , 2000, Blood.

[108]  V. Kroha,et al.  The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias , 1999, Chromosoma.

[109]  Lisa Garrett,et al.  The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia , 1999, Nature Genetics.

[110]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy-number changes using cDNA microarrays , 1999, Nature Genetics.

[111]  B. Johansson,et al.  Cytogenetic polyclonality in hematologic malignancies , 1999, Genes, chromosomes & cancer.

[112]  A. Parreira,et al.  The Nuclear Topography of ABL, BCR, PML, and RAR Genes: Evidence for Gene Proximity in Specific Phases of the Cell Cycle and Stages of Hematopoietic Differentiation , 1999 .

[113]  A. Parreira,et al.  The nuclear topography of ABL, BCR, PML, and RARalpha genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. , 1999, Blood.

[114]  A. Andrén-sandberg,et al.  Cytogenetic analysis of pancreatic carcinomas: Intratumor heterogeneity and nonrandom pattern of chromosome aberrations , 1998, Genes, chromosomes & cancer.

[115]  W. Kuo,et al.  High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays , 1998, Nature Genetics.

[116]  A T Look,et al.  Oncogenic transcription factors in the human acute leukemias. , 1997, Science.

[117]  B. Johansson,et al.  A breakpoint map of recurrent chromosomal rearrangements in human neoplasia , 1997, Nature Genetics.

[118]  K. Kas,et al.  Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations , 1997, Nature Genetics.

[119]  M. Caligiuri,et al.  Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia. , 1996, Blood.

[120]  B. Johansson,et al.  Primary vs. secondary neoplasia‐associated chromosomal abnormalities—balanced rearrangements vs. genomic imbalances? , 1996, Genes, chromosomes & cancer.

[121]  T. Rabbitts,et al.  An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes , 1996, Cell.

[122]  N. Mandahl Cytogenetics and molecular genetics of bone and soft tissue tumors. , 1996, Advances in cancer research.

[123]  A. Pinchera,et al.  Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. , 1995, Cancer research.

[124]  E. Macintyre,et al.  Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. , 1995, Blood.

[125]  T. Rabbitts,et al.  Chromosomal translocations in human cancer , 1994, Nature.

[126]  J. Rowley,et al.  Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. , 1993, Blood.

[127]  D. Baltimore,et al.  E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice , 1993, Molecular and cellular biology.

[128]  M. Santoro,et al.  Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[129]  R. Berger,et al.  Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. , 1991, Oncogene.

[130]  A. Elefanty,et al.  bcr‐abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. , 1990, The EMBO journal.

[131]  G. Jenster,et al.  Acute leukaemia in bcr/abl transgenic mice , 1990, Nature.

[132]  G. Daley,et al.  Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. , 1990, Science.

[133]  F. Mitelman,et al.  Primary chromosome abnormalities in human neoplasia. , 1989, Advances in cancer research.

[134]  F. Mitelman,et al.  Genetic convergence and divergence in tumor progression. , 1988, Cancer research.

[135]  R. Palmiter,et al.  The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice , 1985, Nature.

[136]  P. Nilsson,et al.  Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia. , 1978, Blood.

[137]  P. Nowell The clonal evolution of tumor cell populations. , 1976, Science.

[138]  J. Rowley A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining , 1973, Nature.

[139]  F. Mitelman,et al.  Tumor Etiology and Chromosome Pattern , 1972, Science.

[140]  T. Caspersson,et al.  Differential binding of alkylating fluorochromes in human chromosomes. , 1970, Experimental cell research.

[141]  Amala Chaudhuri,et al.  The chromosome number in man , 1963, Indian journal of pediatrics.

[142]  P. Nowell,et al.  A minute chromosome in human chronic granulocytic leukemia , 1960 .

[143]  A. Levan Chromosome studies on some human tumors and tissues of normal origin, grown in vivo and in vitro at the Sloan‐Kettering Institute , 1956, Cancer.

[144]  S. Makino FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATS , 1955, Annals of the New York Academy of Sciences.

[145]  T. Hauschka SECTION OF BIOLOGY*: CELL POPULATION STUDIES ON MOUSE ASCITES TUMORS† , 1953 .

[146]  T. Hauschka Cell population studies on mouse ascites tumors. , 1953, Transactions of the New York Academy of Sciences.

[147]  Theodor Boveri Zur Frage der Entstehung maligner Tumoren , 1914 .