Intrathecal Bupivacaine for Chronic Pain: A Review of Current Knowledge

Objective. This article presents an overview of the use of intrathecal bupivacaine (with and without opioid), focusing on laboratory data and clinical use for chronic pain. Some background on epidural use is included to support the intrathecal literature.

[1]  T. Deer,et al.  Stability, Compatibility, and Safety of Intrathecal Bupivacaine Administered Chronically via an Implantable Delivery System , 2001, The Clinical journal of pain.

[2]  S. Hassenbusch,et al.  Current practices in intraspinal therapy--a survey of clinical trends and decision making. , 2000, Journal of pain and symptom management.

[3]  T. Yaksh,et al.  Long‐term spinal analgesic delivery: A review of the preclinical and clinical literature , 2000, Regional anesthesia and pain medicine.

[4]  O. Dale,et al.  Focus on mobilisation after lower abdominal surgery. A double‐blind randomised comparison of epidural bupivacaine with morphine vs. lidocaine with morphine for postoperative analgesia , 1999, Acta anaesthesiologica Scandinavica.

[5]  L. Arendt-Nielsen,et al.  Block of pinprick and cold sensation poorly correlate with relief of postoperative pain during epidural analgesia. , 1999, The Clinical journal of pain.

[6]  T. Terao,et al.  A new treatment of severe pre-eclampsia by long-term epidural anaesthesia , 1999, Journal of Human Hypertension.

[7]  K J Burchiel,et al.  A prospective study of long-term intrathecal morphine in the management of chronic nonmalignant pain. , 1999, Neurosurgery.

[8]  S. Mercadante Neuraxial techniques for cancer pain: an opinion about unresolved therapeutic dilemmas. , 1999, Regional anesthesia and pain medicine.

[9]  H. Breivik,et al.  Adrenaline markedly improves thoracic epidural analgesia produced by a low‐dose infusion of bupivacaine, fentanyl and adrenaline after major surgery: A randomised, double‐blind, cross‐over study with and without adrenaline , 1998, Acta anaesthesiologica Scandinavica.

[10]  I. Curelaru,et al.  Efficacy and technical complications of long-term continuous intraspinal infusions of opioid and/or bupivacaine in refractory nonmalignant pain: a comparison between the epidural and the intrathecal approach with externalized or implanted catheters and infusion pumps. , 1998, The Clinical journal of pain.

[11]  Spencer S. Liu,et al.  Patient‐controlled Epidural Analgesia with Bupivacaine and Fentanyl on Hospital Wards: Prospective Experience with 1,030 Surgical Patients , 1998, Anesthesiology.

[12]  I. Curelaru,et al.  Continuous infusion of opioid and bupivacaine by externalized intrathecal catheters in long-term treatment of "refractory" nonmalignant pain. , 1998, The Clinical journal of pain.

[13]  J. Eisenach,et al.  Effects of Intrathecal Neostigmine, Bupivacaine, and Their Combination on Sympathetic Nerve Activity in Rats , 1997, Anesthesiology.

[14]  J. Lange,et al.  Neurohistopathological findings after continuous intrathecal administration of morphine or a morphine/ bupivacaine mixture in cancer pain patients , 1997, Acta anaesthesiologica Scandinavica.

[15]  E. Eide,et al.  Postoperative epidural infusion of morphine and bupivacaine is safe on surgical wards , 1997, Acta anaesthesiologica Scandinavica.

[16]  G. Brodner,et al.  The Effects of Adding Sufentanil to Bupivacaine for Postoperative Patient-Controlled Epidural Analgesia , 1997, Anesthesia and analgesia.

[17]  B. Crul,et al.  Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression , 1997, Pain.

[18]  T. Schnider,et al.  Population Pharmacodynamic Modeling and Covariate Detection for Central Neural Blockade , 1996, Anesthesiology.

[19]  R. Etches,et al.  Patient-Controlled Epidural Analgesia After Thoracotomy: A Comparison of Meperidine With and Without Bupivacaine , 1996, Anesthesia and analgesia.

[20]  M. Baudrimont,et al.  A Chronic Model for Experimental Investigation of Epidural Anesthesia in the Rabbit , 1996, Regional Anesthesia & Pain Medicine.

[21]  D. Scott,et al.  Postoperative Analgesia Using Epidural Infusions of Fentanyl with Bupivacaine: A Prospective Analysis of 1,014 Patients , 1995, Anesthesiology.

[22]  I. Curelaru,et al.  Complications of Intrathecal Opioids and Bupivacaine in the Treatment of “Refractory” Cancer Pain , 1995, The Clinical journal of pain.

[23]  L. Arendt-Nielsen,et al.  Quantitative sensory examination of epidural anaesthesia and analgesia in man: Effects of pre- and post-traumatic morphine on hyperalgesia , 1994, Pain.

[24]  B. Parker,et al.  Epidural Analgesia versus Intravenous Patient‐controlled Analgesia: Differences in the Postoperative Course of Cancer Patients , 1994, Regional anesthesia.

[25]  H. Carp,et al.  Intrathecal cholinergic agonists lessen bupivacaine spinal-block-induced hypotension in rats. , 1994, Anesthesia and analgesia.

[26]  H. Wulf,et al.  The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes. , 1994, Journal of Pain and Symptom Management.

[27]  I. Curelaru,et al.  Long‐term Intrathecal Morphine and Bupivacaine in Patients with Refractory Cancer Pain Results from a Morphine, Bupivacaine Dose Regimen of 0.5:4.75 mg/ml , 1994, Anesthesiology.

[28]  R. Lanning,et al.  Intrathecal infusional analgesia for nonmalignant pain: analgesic efficacy of intrathecal opioid with or without bupivacaine. , 1993, Journal of pain and symptom management.

[29]  B. Crul,et al.  Long-term intrathecal infusion of morphine and morphine/bupivacaine mixtures in the treatment of cancer pain: A retrospective analysis of 51 cases , 1993, Pain.

[30]  H. Kehlet,et al.  Blood pressure and heart rate during orthostatic stress and walking with continuous postoperative thoracic epidural bupivacaine/morphine , 1993, Acta anaesthesiologica Scandinavica.

[31]  T. Yaksh,et al.  Interaction of intrathecal morphine with bupivacaine and lidocaine in the rat. , 1992, Anesthesiology.

[32]  B. Veering,et al.  The Effect of Age on the Systemic Absorption, Disposition and Pharmacodynamics of Bupivacaine After Epidural Administration , 1992, Clinical pharmacokinetics.

[33]  I. Curelaru,et al.  Bacteriology, Drug Stability and Exchange of Percutaneous Delivery Systems and Antibacterial Filters in Long‐Term Intrathecal Infusion of Opioid Drugs and Bupivacaine in “Refractory” Pain , 1992, The Clinical journal of pain.

[34]  L. Boxer,et al.  ALFENTANIL AND PROPOFOL FOR BONE MARROW PROCEDURES: A DOSE-RESPONSE STUDY , 1992 .

[35]  J. Harbers,et al.  Thoracic Epidural Bupivacaine Plus Sufentanil: High Concentration/Low Volume Versus Low Concentration/High Volume , 1992, Regional Anesthesia & Pain Medicine.

[36]  H. Kehlet,et al.  Differential analgesic effects of low-dose epidural morphine and morphine-bupivacaine at rest and during mobilization after major abdominal surgery. , 1992, Anesthesia and analgesia.

[37]  C. Nordborg,et al.  Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients. , 1992, Anesthesiology.

[38]  S. Einarsson,et al.  Long‐term intrathecal morphine and bupivacaine in “refractory” cancer pain. I. Results from the first series of 52 patients , 1991, Acta anaesthesiologica Scandinavica.

[39]  L. Linder,et al.  Epidural versus intrathecal morphine-bupivacaine: assessment of consecutive treatments in advanced cancer pain. , 1990, Journal of pain and symptom management.

[40]  A. Burm,et al.  Clinical Pharmacokinetics of Epidural and Spinal Anaesthesia , 1989, Clinical pharmacokinetics.

[41]  N. Vermeulen,et al.  Pharmacokinetics of Lignocaine and Bupivacaine in Surgical Patients Following Epidural Administration , 1987, Clinical pharmacokinetics.

[42]  R. Penn,et al.  The Effect of Chronic Subarachnoid Bupivacaine Infusion in Dogs , 1987, Anesthesiology.

[43]  P. Rosenberg,et al.  Effects of continuous epidural administration of bupivacaine through a catheter in pigs. , 1986, European journal of anaesthesiology.

[44]  M. Bahar,et al.  Neurological toxicity of the subarachnoid infusion of bupivacaine, lignocaine or 2-chloroprocaine in the rat. , 1986, British journal of anaesthesia.

[45]  T. Yaksh,et al.  Epidural Injections of Bupivacaine, Morphine, Fentanyl, Lofentanil, and DADL in Chronically Implanted Rats: A Pharmacologic and Pathologic Study , 1986, Anesthesiology.

[46]  L. Worthley Thoracic epidural in the management of chest trauma , 1985, Intensive Care Medicine.

[47]  H. Kehlet,et al.  SYSTEMIC MORPHINE ENHANCES SPREAD OF SENSORY ANALGESIA DURING POSTOPERATIVE EPIDURAL BUPIVACAINE INFUSION , 1985, The Lancet.

[48]  H. Refsum,et al.  Cardiac electrophysiologic and hemodynamic effects related to plasma levels of bupivacaine in the dog. , 1985, Anesthesia and analgesia.

[49]  A. Rankin,et al.  Management of Fifty Cases of Chest Injury with a Regimen of Epidural Bupivacaine and Morphine , 1984, Anaesthesia and intensive care.

[50]  R. Shams,et al.  The effect of Marcaine epidural anaesthesia on the spinal cord injured dog , 1979, Paraplegia.

[51]  L. Carrie,et al.  Continuous epidural infusion of bupivacaine in labour , 1979, Anaesthesia.

[52]  R. Verwilghen,et al.  DANGERS OF PETROL USED AS SOLVENT , 1975, The Lancet.

[53]  Ruth E. Brown,et al.  Cost-effectiveness of long-term intrathecal morphine therapy for pain associated with failed back surgery syndrome. , 1997, Clinical therapeutics.

[54]  C. Nordborg,et al.  Spinal epidural metastasis: implications for spinal analgesia to treat "refractory" cancer pain. , 1997, Journal of pain and symptom management.

[55]  J. Brennum,et al.  Quantitative sensory examination of epidural anaesthesia and analgesia in man. , 1996, Acta physiologica Scandinavica. Supplementum.

[56]  H. Tullos,et al.  Continuous epidural analgesia using fentanyl and bupivacaine after total knee arthroplasty. , 1994, Clinical orthopaedics and related research.

[57]  G. Lachâtre,et al.  Pharmacocinétique de la bupivacaïne administrée par voie péridurale ou sous-arachnoïdienne pour césarienne réglée , 1993 .

[58]  J. Debord,et al.  [Pharmacokinetics of epidural or intrathecal bupivacaine in elective cesarean section]. , 1993, Annales francaises d'anesthesie et de reanimation.

[59]  J. Willaert,et al.  Postoperative analgesia for major abdominal surgery with continuous thoracic epidural infusion of bupivacaine with sufentanil, versus bupivacaine with morphine. A randomized double blind study. , 1992, Acta anaesthesiologica Belgica.

[60]  R. Giudicelli,et al.  [Prolonged epidural analgesia following thoracotomy. Clinical study and serum levels over five days]. , 1991, Annales de chirurgie.

[61]  Lawrence A. Trissel,et al.  Handbook on Injectable Drugs , 1983 .