ß-Lactam-ß-lactamase Inhibitor Combination against ESBL-Producing Enterobacteriaceae

In the last decades, Extended-Spectrum-β-Lactamases (ESBLs) in gram negative bacilli have appeared as a significant mechanism of resistance to antibiotics. Although resistance to carbapenems is increasing among bacteria, they are still the treatment of choice for serious infections caused by ESBL producers. Therefore, the aim of the present study was to evaluate the effect of ß-lactam-ß-lactamase inhibitor combination against ESBL-producing Enterobacteriaceae. This is a review study. The PubMed and google scholar databases were searched using the following Klebsiella pneumoniae, Escherichia and beta-lactamase genes in the time interval from 2008 to 2015. Overall, Ninety one papers were found and included in this study. The results of the study revealed that the use of beta-lactamase inhibitors in combination with beta-lactam antibiotics is currently the most successful strategy for infections caused by extended-spectrum β-lactamase producers.

[1]  A. Ansari-Moghaddam,et al.  Prevalence of CTX-M-8 and CTX-M-15 type extended-spectrum beta-lactamases between Klebsiella pneumoniae spp. isolated from Zahedan, Southeast Iran , 2016, Journal of chemotherapy.

[2]  Hashemi Ali.  β-LACTAM-β-LACTAMASE INHIBITOR COMBINATION AGAINST ESBL-PRODUCING ENTEROBACTERIACEAE (REVIEW ARTICLE) , 2016 .

[3]  M. Mozafari,et al.  Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients. , 2015, Burns : journal of the International Society for Burn Injuries.

[4]  A. Doosti,et al.  Molecular Epidemiology of ESBL Genes and Multi-Drug Resistance in Diarrheagenic Escherichia Coli Strains Isolated from Adults in Iran , 2015, Iranian journal of pharmaceutical research : IJPR.

[5]  F. Firoozeh,et al.  Characterization of CTX-M-Type Extend-Spectrum β-Lactamase Producing Klebsiella spp. in Kashan, Iran , 2015, Jundishapur journal of microbiology.

[6]  A. Eakin,et al.  Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam. , 2015, The Journal of antimicrobial chemotherapy.

[7]  Michael J. Rybak,et al.  The β‐Lactams Strike Back: Ceftazidime‐Avibactam , 2015, Pharmacotherapy.

[8]  Jonathan C. Cho,et al.  Ceftolozane/Tazobactam: A Novel Cephalosporin/β‐Lactamase Inhibitor Combination , 2015, Pharmacotherapy.

[9]  Mohammad Reza Aflatoonian,et al.  Genotyping of ESBL producing uropathogenic and diarrheagenic Escherichia coli in southeast of Iran. , 2015, Infectious disorders drug targets.

[10]  M. S. Rezai,et al.  Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran , 2015, BioMed research international.

[11]  H. Goudarzi,et al.  Detection of Metallo-beta-Lactamases, Extended-spectrum Beta-lactamases (ESBLs), Outer Membrane Porins among Klebsiella Pneumoniae Strains Isolated from Hospitalized Patients in Tehran , 2015 .

[12]  M. Memariani,et al.  Occurrence of SHV, TEM and CTX-M β-Lactamase Genes Among Enteropathogenic Escherichia coli Strains Isolated From Children With Diarrhea , 2015, Jundishapur journal of microbiology.

[13]  S. Saeidi,et al.  Antibacterial Activity of Some Plant Extracts Against Extended- Spectrum Beta-Lactamase Producing Escherichia coli Isolates , 2015, Jundishapur journal of microbiology.

[14]  M. Alikhani,et al.  Prevalence of ESBL and MBL encoding genes in Acinetobacter baumannii strains isolated from patients of intensive care units (ICU) , 2015, Saudi journal of biological sciences.

[15]  A. Doosti,et al.  TEM and SHV Genes in Klebsiella pneumoniae Isolated from Cockroaches and Their Antimicrobial Resistance Pattern , 2014, Osong public health and research perspectives.

[16]  L. Kremer,et al.  β-Lactamase inhibition by avibactam in Mycobacterium abscessus. , 2014, The Journal of antimicrobial chemotherapy.

[17]  Alireza Ansari- Moghaddam,et al.  Frequency of PER, VEB, SHV, TEM and CTX-M Genes in Resistant Strains of Pseudomonas aeruginosa Producing Extended Spectrum β-Lactamases , 2014, Jundishapur journal of microbiology.

[18]  L. Leibovici,et al.  β-Lactam/β-lactamase inhibitors versus carbapenems for the treatment of sepsis: systematic review and meta-analysis of randomized controlled trials. , 2015, The Journal of antimicrobial chemotherapy.

[19]  H. Goudarzi,et al.  Evaluation of Genetic Pattern and Determination of oqxA Gene Expression Levels among Clinical Isolates of Klebsiella Pneumoniae Strains , 2014 .

[20]  A. Khosravi,et al.  Spread of extended-spectrum β-lactamase genes of blaOXA-10, blaPER-1 and blaCTX-M in Pseudomonas aeruginosa strains isolated from burn patients. , 2014, Burns : journal of the International Society for Burn Injuries.

[21]  Tayebi Zahra,et al.  Prevalence of blaCTX-M gene in multi-resistant Escherichia coli isolated from Urinary Tract Infections, Tehran, Iran , 2014 .

[22]  H. Goudarzi,et al.  Detection of FOX, MOX, and ACT Genes in ESBL-producing Klebsiella pneumoniae Strains , 2014 .

[23]  S. Siadat,et al.  Diversity of β-lactamases produced by imipenem resistant, Pseudomonas aeruginosa isolates from the bloodstream. , 2014, Burns : journal of the International Society for Burn Injuries.

[24]  H. Momtaz,et al.  Virulence Gene Profiles of Multidrug-Resistant Pseudomonas aeruginosa Isolated From Iranian Hospital Infections , 2014, Iranian Red Crescent medical journal.

[25]  A. Gholipour,et al.  Phenotypic and Molecular Characterization of Extended-Spectrum β-Lactamase Produced by Escherichia coli, and Klebsiella pneumoniae Isolates in an Educational Hospital , 2014, Jundishapur journal of microbiology.

[26]  A. Peymani,et al.  Emergence of TEM, SHV, and CTX-M-extended spectrum β-lactamases and class 1 integron among Enterobacter cloacae isolates collected from hospitals of Tehran and Qazvin, Iran. , 2014, Microbial drug resistance.

[27]  H. Goudarzi,et al.  Detection of β-Lactamases and Outer Membrane Porins among Klebsiella pneumoniae Strains Isolated in Iran , 2014, Scientifica.

[28]  S. Siadat,et al.  High rate of aminoglycoside resistance in CTX-M-15 producing Klebsiella pneumoniae isolates in Tehran, Iran. , 2014, Laboratory medicine.

[29]  H. Goudarzi,et al.  Prevalence of bla NDM, bla PER, bla VEB, bla IMP, and bla VIM Genes among Acinetobacter baumannii Isolated from Two Hospitals of Tehran, Iran , 2014, Scientifica.

[30]  J. Solomkin,et al.  Multicenter, Double-Blind, Randomized, Phase II Trial To Assess the Safety and Efficacy of Ceftolozane-Tazobactam plus Metronidazole Compared with Meropenem in Adult Patients with Complicated Intra-Abdominal Infections , 2014, Antimicrobial Agents and Chemotherapy.

[31]  R. Bonomo,et al.  Reclaiming the Efficacy of β-Lactam–β-Lactamase Inhibitor Combinations: Avibactam Restores the Susceptibility of CMY-2-Producing Escherichia coli to Ceftazidime , 2014, Antimicrobial Agents and Chemotherapy.

[32]  M. N. Moghaddam,et al.  Genetic properties of blaCTX-M and blaPER β-lactamase genes in clinical isolates of Enterobacteriaceae by polymerase chain reaction , 2014, Iranian journal of basic medical sciences.

[33]  M. Kargar,et al.  Molecular detection of ESBLs production and antibiotic resistance patterns in Gram negative bacilli isolated from urinary tract infections. , 2014, Indian journal of pathology & microbiology.

[34]  H. Goudarzi,et al.  Detection of Ambler class A, B and D ß-lactamases among Pseudomonas aeruginosa and Acinetobacter baumannii clinical isolates from burn patients. , 2014, Annals of burns and fire disasters.

[35]  H. Zeighami,et al.  Extended spectrum betalactamase producing Enteroaggregative Escherichia coli from young children in Iran , 2014, Gastroenterology and hepatology from bed to bench.

[36]  M. Shokoohi,et al.  Characterization of AmpC, CTX-M and MBLs types of β-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli producing Extended Spectrum β-lactamases in Kerman, Iran , 2014, Jundishapur journal of microbiology.

[37]  F. Fallah,et al.  Evaluation of Zataria MultiFlora Boiss and Carum copticum antibacterial activity on IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa. , 2013, Annals of burns and fire disasters.

[38]  Ronald N. Jones,et al.  Contemporary Diversity of β-Lactamases among Enterobacteriaceae in the Nine U.S. Census Regions and Ceftazidime-Avibactam Activity Tested against Isolates Producing the Most Prevalent β-Lactamase Groups , 2013, Antimicrobial Agents and Chemotherapy.

[39]  M. Jafari,et al.  The First Report of CMY, aac (6′)-Ib and 16S rRNA Methylase Genes Among Pseudomonas aeruginosa Isolates From Iran , 2013 .

[40]  Y. Ghasemi,et al.  Document heading doi : A simple multiplex PCR for assessing prevalence of extended-spectrum 毬-lactamases producing Klebsiella pneumoniae in Intensive Care Units of a referral hospital in Shiraz , Iran , 2013 .

[41]  F. Fallah,et al.  Carbapenem-Resistant Bacteria and Laboratory Detection Methods , 2013 .

[42]  M. Scheetz,et al.  Correlations of Antibiotic Use and Carbapenem Resistance in Enterobacteriaceae , 2013, Antimicrobial Agents and Chemotherapy.

[43]  H. Goudarzi,et al.  Identification of extended-spectrum-beta- lactamases(ESBLs), metallo-beta-lactamases (MBLs), Amp-C and KPC ß-lactamases among Klebsiella pneumoniae isolated from adults and pediatric patients in Iran , 2013 .

[44]  S. Farajnia,et al.  Prevalence of PER and VEB Type Extended Spectrum Betalactamases among Multidrug Resistant Acinetobacter baumannii Isolates in North-West of Iran , 2013, Iranian journal of basic medical sciences.

[45]  P. Owlia,et al.  The occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran , 2013, Iranian journal of microbiology.

[46]  H. Goudarzi,et al.  Characterization of the Extended-Spectrum beta-Lactamase Producers among Non-Fermenting Gram-Negative Bacteria Isolated from Burnt Patients , 2013 .

[47]  D. Livermore.  Current Epidemiology and Growing Resistance of Gram-Negative Pathogens , 2012, The Korean journal of internal medicine.

[48]  M. M. Forghanifard,et al.  Prevalence and Molecular Characterization of Plasmid-mediated Extended-Spectrum β-Lactamase Genes (balaTEM, blaCTX and blASHV) Among Urinary Escherichia coli Clinical Isolates in Mashhad, Iran , 2012, Iranian journal of basic medical sciences.

[49]  M. Barati,et al.  Antibacterial effect of Methanolic extract of Camellia Sinensis L. on Pseudomonas aeruginosa strains producing β-lactamases , 2012 .

[50]  Jung Hun Lee,et al.  New definitions of extended‐spectrum β‐lactamase conferring worldwide emerging antibiotic resistance , 2012, Medicinal research reviews.

[51]  Z. Aktaş,et al.  In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae. , 2012, International journal of antimicrobial agents.

[52]  M. Aghazadeh,et al.  Prevalence of PER-1- type Extended-Spectrum Beta-Lactamaes in Clinical Strains of Pseudomonas aeruginosa Isolated from Tabriz, Iran , 2012, Iranian journal of basic medical sciences.

[53]  Z. Sekawi,et al.  Incidence of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in patients with urinary tract infection. , 2012, Sao Paulo medical journal = Revista paulista de medicina.

[54]  F. Fallah,et al.  Global spread of New Delhi mettallo-beta-lactamase-1(NDM-1). , 2011 .

[55]  Hajo Grundmann,et al.  Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia: Estimating the Burden of Antibiotic Resistance in Europe , 2011, PLoS medicine.

[56]  M. Barati,et al.  ANTIBACTERIAL EFFECTS OF METHANOLIC EXTRACTS OF ZATARIA MULTIFLORA, MYRTUS COMMUNIS AND PEGANUM HARMALA ON PSEUDOMONAS AERUGINOSA PRODUCING ESBL , 2011 .

[57]  N. Shoeib,et al.  Molecular characterization of CTX-Mβ-lactamases among Klebsiella pneumoniae isolated from patients at Tehran hospitals. , 2011 .

[58]  D. Paterson,et al.  Antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region according to currently established susceptibility interpretive criteria. , 2011, The Journal of infection.

[59]  V. Yewale,et al.  Beta lactam and beta lactamase inhibitor combinations , 2010 .

[60]  J. Pachón,et al.  Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates. , 2010, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[61]  R. Bonomo,et al.  Three Decades of β-Lactamase Inhibitors , 2010, Clinical Microbiology Reviews.

[62]  D. Paterson,et al.  High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern India. , 2008, The Journal of antimicrobial chemotherapy.

[63]  M. Rahbar,et al.  Prevalence of extended-spectrum β-lactamase-producing Escherichia coli in a tertiary care hospital in Tehran, Iran , 2008 .

[64]  F. Baquero,et al.  Dissemination of Clonally Related Escherichia coli Strains Expressing Extended-Spectrum β-Lactamase CTX-M-15 , 2008, Emerging infectious diseases.

[65]  D. Nicolau.  Carbapenems: a potent class of antibiotics , 2008, Expert opinion on pharmacotherapy.

[66]  R. Cantón,et al.  IRT and CMT β‐lactamases and inhibitor resistance , 2008 .

[67]  D. Livermore,et al.  Orthodox and unorthodox clavulanate combinations against extended-spectrum beta-lactamase producers. , 2008, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[68]  R. Thomson,,et al.  Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella Species , 2006, Antimicrobial Agents and Chemotherapy.

[69]  Robert A. Bonomo,et al.  Extended-Spectrum (cid:2) -Lactamases: a Clinical Update , 2005 .

[70]  D. Burgess,et al.  In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. , 2004, Diagnostic microbiology and infectious disease.

[71]  G. Jacoby,et al.  Epidemiology of Conjugative Plasmid-Mediated AmpC β-Lactamases in the United States , 2004, Antimicrobial Agents and Chemotherapy.

[72]  Kenneth S. Thomson,et al.  Cefepime, Piperacillin-Tazobactam, and the Inoculum Effect in Tests with Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae , 2001, Antimicrobial Agents and Chemotherapy.

[73]  O. Tansel,et al.  Conjugative resistance to tazobactam plus piperacillin among extended-spectrum beta-lactamase-producing nosocomial Klebsiella pneumoniae. , 2001, Scandinavian journal of infectious diseases.

[74]  A. Medeiros.  Nosocomial Outbreaks of Multiresistant Bacteria: Extended-Spectrum Beta-Lactamases Have Arrived in North America , 1993, Annals of Internal Medicine.

[75]  B. Wiedemann,et al.  Evolution of plasmid-coded resistance to broad-spectrum cephalosporins , 1985, Antimicrobial Agents and Chemotherapy.

[76]  W. Szybalski,et al.  Microbial drug resistance. , 1955, Advances in genetics.