Distensibility of the ascending aorta in coronary artery disease and changes after nifedipine administration.

To study the effect of nifedipine on aortic distensibility in patients with coronary artery disease, ascending aorta distensibility was measured before and 10 min after 10 mg of nifedipine was given sublingually in 13 patients with coronary artery disease and 12 control subjects. Aortic distensibility was calculated as a function of changes in the aortic diameter and pulse pressure. Aortic diameters were measured by echocardiography and aortic pressures were measured directly by catheterization of the ascending aorta. At baseline, aortic distensibility was lower in patients with coronary artery disease compared with control (0.922 +/- 0.367 vs 2.456 +/- 0.588 10(-6).cm2.dyn-1, respectively, p < 0.001). After nifedipine administration, aortic distensibility increased significantly both in normal subjects (by 0.812 +/- 0.316 10(-6).cm2.dyn-1-36.5 +/- 19 percent; p < 0.001) and in patients with coronary artery disease (by 0.296 +/- 0.203 10(-6).cm2.dyn-1-36.6 +/- 28.2 percent; p < 0.001). These results indicate that nifedipine administration increases aortic distensibility in both normal subjects and patients with coronary artery disease.

[1]  J. Ross,et al.  Effects of decreased aortic compliance on performance of the left ventricle. , 1968, The American journal of physiology.

[2]  J. Malcolm,et al.  Experimental infarction (medial necrosis) of the dog's aorta. , 1965, American Journal of Pathology.

[3]  G. Sicard.  The Marfan syndrome: Abnormal aortic elastic properties: Hirata K, Triposkiadis F, Sparks E, Bowen J, Wooley CF, Boudoulas H. J Am Coll Cardiol 1991;18:57–63 , 1993 .

[4]  S. Sasayama,et al.  Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. , 1989, Circulation.

[5]  Kiichi Sagawa,et al.  Effect of nitroglycerin on aortic impedance, diameter, and pulse-wave velocity. , 1988 .

[6]  Katsuyuki Yamamoto,et al.  Non-invasive ultrasonic measurement of the elastic properties of the human abdominal aorta. , 1986, Cardiovascular research.

[7]  C. Wooley,et al.  The Marfan syndrome: abnormal aortic elastic properties. , 1991, Journal of the American College of Cardiology.

[8]  C. Vlachopoulos,et al.  Medial necrosis and acute alterations in aortic distensibility following removal of the vasa vasorum of canine ascending aorta. , 1993, Cardiovascular research.

[9]  A. Dart,et al.  Aortic distensibility in patients with isolated hypercholesterolaemia, coronary artery disease, or cardiac transplant , 1991, The Lancet.

[10]  C. Stefanadis,et al.  Aortic distensibility in post-stenotic aortic dilatation: the effect of co-existing coronary artery disease. , 1988, Journal of cardiology.

[11]  R. Ross.  The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[12]  M. O'Rourke,et al.  Effect of glyceryl trinitrate on peripheral arteries alters left ventricular hydraulic load in man. , 1986, Cardiovascular research.

[13]  F. Abboud,et al.  Effects of chronic hypertension on vasa vasorum in the thoracic aorta. , 1985, Cardiovascular research.

[14]  P Toutouzas,et al.  Distensibility of the ascending aorta: comparison of invasive and non-invasive techniques in healthy men and in men with coronary artery disease. , 1990, European heart journal.

[15]  A. Mark,et al.  Augmented Responses to Vasoconstrictor Stimuli in Hypercholesterolemic and Atherosclerotic Monkeys , 1984, Circulation research.

[16]  M. Yano,et al.  Evaluation of aortic wall distensibility by aortic pressure-dimension relation: effects of nifedipine on aortic wall. , 1987, Cardiovascular research.

[17]  L. Solberg,et al.  Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex. , 1968, Laboratory investigation; a journal of technical methods and pathology.

[18]  Robert H. Wilkins,et al.  Autopsy Studies in Atherosclerosis: I. Distribution and Severity of Atherosclerosis in Patients Dying without Morphologic Evidence of Atherosclerotic Catastrophe , 1959 .

[19]  M. O'Rourke.  Systolic blood pressure: arterial compliance and early wave reflection, and their modification by antihypertensive therapy. , 1989, Journal of human hypertension.

[20]  J. Ehrhardt,et al.  Regulation of blood flow to the aortic media in dogs. , 1978, The Journal of clinical investigation.

[21]  S. Barsky,et al.  Aortic Infarction Following Dissecting Aortic Aneurysm , 1978, Circulation.

[22]  D N Firmin,et al.  The function of the aorta in ischemic heart disease: a magnetic resonance and angiographic study of aortic compliance and blood flow patterns. , 1989, American heart journal.

[23]  I. Kallikazaros,et al.  Ascending aorta distensibility abnormalities in hypertensive patients and response to nifedipine administration. , 1992, The American journal of medicine.

[24]  R. Mohiaddin,et al.  Regional aortic compliance studied by magnetic resonance imaging: the effects of age, training, and coronary artery disease. , 1989, British heart journal.

[25]  D. Fitchett,et al.  Reflected pressure waves in the ascending aorta: effect of glyceryl trinitrate. , 1988, Cardiovascular research.

[26]  C. Stefanadis,et al.  Aortic distensibility abnormalities in coronary artery disease. , 1987, The American journal of cardiology.

[27]  R. O'rourke,et al.  Accuracy of echocardiography for assessing aortic root diameter. , 1975, British heart journal.

[28]  Y. Fung,et al.  Mechanics of the Circulation , 2011, Developments in Cardiovascular Medicine.