Fluorescent copper nanoparticles: recent advances in synthesis and applications for sensing metal ions.

Fluorescent copper nanoparticles (F-CuNPs) have received great attention due to their attractive features, such as water solubility, wide availability, ease of functionalization and good biocompatibility, and considerable efforts have been devoted to the preparation and applications of F-CuNPs. This review article comprises three main parts. In the first part, we briefly present the fluorescence properties of F-CuNPs. Then we cover the fabrication strategies of various F-CuNPs functionalized by different ligands. In the third part, we focus on the applications of F-CuNPs for sensing metal ions, including Hg(2+), Pb(2+), Cu(2+), Fe(3+) and other metal ions. Lastly, we further discuss the opportunities and challenges of F-CuNPs in the synthetic strategies and applications for sensing metal ions.

[1]  Zhiqin Yuan,et al.  The isomeric effect of mercaptobenzoic acids on the preparation and fluorescence properties of copper nanoclusters. , 2015, Chemical communications.

[2]  Wei Chen,et al.  One-pot synthesis, photoluminescence, and electrocatalytic properties of subnanometer-sized copper clusters. , 2011, Journal of the American Chemical Society.

[3]  Wei Chen,et al.  Copper nanoclusters: Synthesis, characterization and properties , 2012 .

[4]  Yongming Guo,et al.  Fluorescent carbon nanoparticles for the fluorescent detection of metal ions. , 2015, Biosensors & bioelectronics.

[5]  Bowen Zhu,et al.  Optical reading of contaminants in aqueous media based on gold nanoparticles. , 2014, Small.

[6]  Qiang Zhang,et al.  Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles , 2013, Journal of Nanoparticle Research.

[7]  P. Townsend,et al.  Luminescence from copper nanoparticles , 2001 .

[8]  Wei Chen,et al.  Sub-nanometre sized metal clusters: from synthetic challenges to the unique property discoveries. , 2012, Chemical Society reviews.

[9]  Kemin Wang,et al.  dsDNA-specific fluorescent copper nanoparticles as a "green" nano-dye for polymerization-mediated biochemical analysis. , 2014, Chemical communications.

[10]  Jianping Xie,et al.  Protein-directed synthesis of highly fluorescent gold nanoclusters. , 2009, Journal of the American Chemical Society.

[11]  Hai-Bo Wang,et al.  A fluorescent biosensor for protein detection based on poly(thymine)-templated copper nanoparticles and terminal protection of small molecule-linked DNA. , 2015, Biosensors & bioelectronics.

[12]  S. Ghosh,et al.  Blue-emitting copper nanoclusters synthesized in the presence of lysozyme as candidates for cell labeling. , 2014, ACS applied materials & interfaces.

[13]  Xiaoliang Zhang,et al.  Photoinduced silver nanoparticles/nanorings on plasmid DNA scaffolds. , 2012, Small.

[14]  M. Muniz-Miranda,et al.  Characterization of Copper nanoparticles obtained by laser ablation in liquids , 2013 .

[15]  X. Qu,et al.  Toward site-specific, homogeneous and highly stable fluorescent silver nanoclusters fabrication on triplex DNA scaffolds , 2012, Nucleic acids research.

[16]  Arben Merkoçi,et al.  Recent trends in macro-, micro-, and nanomaterial-based tools and strategies for heavy-metal detection. , 2011, Chemical reviews.

[17]  J. Rivas,et al.  Copper clusters as novel fluorescent probes for the detection and photocatalytic elimination of lead ions. , 2014, Physical chemistry chemical physics : PCCP.

[18]  Kemin Wang,et al.  Visual and portable strategy for copper(II) detection based on a striplike poly(thymine)-caged and microwell-printed hydrogel. , 2014, Analytical chemistry.

[19]  Xingyu Jiang,et al.  Hydrothermal synthesis of highly fluorescent carbon nanoparticles from sodium citrate and their use for the detection of mercury ions , 2013 .

[20]  Shenghao Xu,et al.  Sequence-dependent dsDNA-templated formation of fluorescent copper nanoparticles. , 2015, Chemistry.

[21]  Samir Kumar Pal,et al.  Copper Quantum Clusters in Protein Matrix: Potential Sensor of Pb 2+ Ion , 2022 .

[22]  Andriy Mokhir,et al.  Selective dsDNA-templated formation of copper nanoparticles in solution. , 2010, Angewandte Chemie.

[23]  Yagang Yao,et al.  One-step synthesis of fluorescent smart thermo-responsive copper clusters: A potential nanothermometer in living cells , 2015, Nano Research.

[24]  Xingguo Chen,et al.  Polyethyleneimine-templated copper nanoclusters via ascorbic acid reduction approach as ferric ion sensor. , 2015, Analytica chimica acta.

[25]  R. Das,et al.  Synthesis of Linoleic Acid Capped Copper Nanoparticles and Their Fluorescence Study , 2011, Journal of Fluorescence.

[26]  Kemin Wang,et al.  Poly(thymine)-templated selective formation of fluorescent copper nanoparticles. , 2013, Angewandte Chemie.

[27]  M. Winter,et al.  Size-selective electrochemical preparation of surfactant-stabilized Pd-, Ni- and Pt/Pd colloids. , 2001, Chemistry.

[28]  Robert M Dickson,et al.  Developing luminescent silver nanodots for biological applications. , 2012, Chemical Society reviews.

[29]  Hao Zhang,et al.  Assembly-Induced Enhancement of Cu Nanoclusters Luminescence with Mechanochromic Property. , 2015, Journal of the American Chemical Society.

[30]  H. Kawasaki,et al.  Surfactant-free single-nano-sized colloidal Cu nanoparticles for use as an active catalyst in Ullmann-coupling reaction. , 2012, Chemical communications.

[31]  Lingwen Zeng,et al.  Random dsDNA-templated formation of copper nanoparticles as novel fluorescence probes for label-free lead ions detection. , 2012, Chemical communications.

[32]  Kamaljit Singh,et al.  Strategies in detection of metal ions using dyes , 2014 .

[33]  Xiao-yan Li,et al.  Poly(thymine)-templated fluorescent copper nanoparticles for ultrasensitive label-free detection of Pb²⁺ ion. , 2014, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[34]  Fei Qu,et al.  Fluorescent detection of hydrogen peroxide and glucose with polyethyleneimine-templated Cu nanoclusters. , 2014, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[35]  Huzhi Zheng,et al.  Copper nanoclusters as a highly sensitive and selective fluorescence sensor for ferric ions in serum and living cells by imaging. , 2014, Biosensors & bioelectronics.

[36]  José Rivas,et al.  Synthesis of small atomic copper clusters in microemulsions. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[37]  Chi Zhang,et al.  Protein-directed synthesis of pH-responsive red fluorescent copper nanoclusters and their applications in cellular imaging and catalysis. , 2014, Nanoscale.

[38]  Qingpu Wang,et al.  A novel fluorescence and naked eye sensor for iodide in urine based on the iodide induced oxidative etching and aggregation of Cu nanoclusters , 2015 .

[39]  Z. Chai,et al.  Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines. , 2013, Chemical communications.

[40]  T. Pradeep,et al.  A copper cluster protected with phenylethanethiol , 2013, Journal of Nanoparticle Research.

[41]  S. Ghosh,et al.  Synergistic anticancer activity of fluorescent copper nanoclusters and cisplatin delivered through a hydrogel nanocarrier. , 2015, ACS applied materials & interfaces.

[42]  Chao Lu,et al.  A highly selective fluorescent probe for sulfide ions based on aggregation of Cu nanocluster induced emission enhancement. , 2015, The Analyst.

[43]  C. Huang,et al.  One-step prepared fluorescent copper nanoclusters for reversible pH-sensing. , 2014, The Analyst.

[44]  Qingpu Wang,et al.  Copper nanoclusters coated with bovine serum albumin as a regenerable fluorescent probe for copper(II) ion , 2015, Microchimica Acta.

[45]  Xiaodong Zhang,et al.  Thermal evolution and optical properties of Cu nanoparticles in SiO2 by ion implantation , 2011 .

[46]  Hai-Bo Wang,et al.  A rapid, sensitive and label-free sensor for Hg(II) ion detection based on blocking of cysteine-quenching of fluorescent poly(thymine)-templated copper nanoparticles , 2015 .

[47]  Xingyu Jiang,et al.  Stable fluorescent gold nanoparticles for detection of Cu2+ with good sensitivity and selectivity. , 2012, The Analyst.

[48]  Arben Merkoçi,et al.  Nanomaterials application in electrochemical detection of heavy metals , 2012 .

[49]  M. Young,et al.  A library of protein cage architectures as nanomaterials. , 2009, Current topics in microbiology and immunology.

[50]  Chi Zhang,et al.  Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb(2+) in living cells. , 2015, The Analyst.

[51]  E. Wang,et al.  Cu nanoclusters with aggregation induced emission enhancement. , 2013, Small.

[52]  Xingyu Jiang,et al.  Colorimetric detection of mercury, lead and copper ions simultaneously using protein-functionalized gold nanoparticles. , 2011, Biosensors & bioelectronics.

[53]  E. Wang,et al.  DNA-hosted copper nanoclusters for fluorescent identification of single nucleotide polymorphisms. , 2012, ACS nano.

[54]  Erkang Wang,et al.  Metal nanoclusters: New fluorescent probes for sensors and bioimaging , 2014 .

[55]  Tao Yu,et al.  In situ synthesis of red emissive copper nanoclusters in supramolecular hydrogels , 2013 .

[56]  M. López-Quintela,et al.  Microemulsion dynamics and reactions in microemulsions , 2004 .

[57]  Rajender S. Varma,et al.  Microwave-assisted chemistry: synthetic applications for rapid assembly of nanomaterials and organics. , 2014, Accounts of chemical research.

[58]  K. Fang,et al.  Green synthesis of peptide-templated fluorescent copper nanoclusters for temperature sensing and cellular imaging. , 2014, The Analyst.

[59]  Sung Ik Yang,et al.  A selective fluorescence turn-on sensing system for evaluation of Cu2+ polluted water based on ultra-fast formation of fluorescent copper nanoclusters , 2015 .

[60]  N. Kaur,et al.  Aqueous-Phase Synthesis of Copper Nanoparticles Using Organic Nanoparticles: Application of Assembly in Detection of Cr3+ , 2014 .

[61]  M. Niederberger,et al.  Microwave chemistry for inorganic nanomaterials synthesis. , 2010, Nanoscale.

[62]  Li Zhang,et al.  Cu nanoclusters-based ratiometric fluorescence probe for ratiometric and visualization detection of copper ions. , 2015, Analytica chimica acta.

[63]  Hai-Bo Wang,et al.  A label-free and ultrasensitive fluorescent sensor for dopamine detection based on double-stranded DNA templated copper nanoparticles , 2015 .

[64]  S. Shu,et al.  A fluorescent biosensor of lysozyme-stabilized copper nanoclusters for the selective detection of glucose , 2015 .

[65]  Yanming Liu,et al.  Poly(thymine)-templated fluorescent copper nanoparticles for label-free detection of N-acetylcysteine in pharmaceutical samples , 2015 .

[66]  Hui Zhang,et al.  Photoreductive synthesis of water-soluble fluorescent metal nanoclusters. , 2012, Chemical communications.

[67]  Qian Liu,et al.  Strong two-photon-induced fluorescence from photostable, biocompatible nitrogen-doped graphene quantum dots for cellular and deep-tissue imaging. , 2013, Nano letters.

[68]  Yanming Liu,et al.  Inhibition of double-stranded DNA templated copper nanoparticles as label-free fluorescent sensors for L-histidine detection , 2015 .

[69]  R. Arakawa,et al.  Microwave-assisted polyol synthesis of copper nanocrystals without using additional protective agents. , 2011, Chemical communications.

[70]  Xiwen He,et al.  Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells. , 2015, Journal of materials chemistry. B.

[71]  Robin H. A. Ras,et al.  Fluorescent silver nanoclusters. , 2011, Nanoscale.

[72]  X. Hou,et al.  Semicondutor quantum dots-based metal ion probes. , 2014, Nanoscale.

[73]  Xiaoming Yang,et al.  One-step synthesis and applications of fluorescent Cu nanoclusters stabilized by L-cysteine in aqueous solution. , 2014, Analytica chimica acta.

[74]  Li Ruiyi,et al.  Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples , 2015 .

[75]  Q. Song,et al.  Synthesis of cysteine-functionalized water-soluble luminescent copper nanoclusters and their application to the determination of chromium(VI) , 2015, Microchimica Acta.

[76]  Amy E. Palmer,et al.  Fluorescent Sensors for Measuring Metal Ions in Living Systems , 2014, Chemical reviews.

[77]  C. Huang,et al.  Water-soluble luminescent copper nanoclusters reduced and protected by histidine for sensing of guanosine 5′-triphosphate , 2014 .

[78]  J. Rivas,et al.  Electrochemical Synthesis of Very Stable Photoluminescent Copper Clusters , 2010 .

[79]  R. Pereiro,et al.  One-step aqueous synthesis of fluorescent copper nanoclusters by direct metal reduction , 2013, Nanotechnology.

[80]  Tian Gan,et al.  H2O2-mediated fluorescence quenching of double-stranded DNA templated copper nanoparticles for label-free and sensitive detection of glucose , 2015 .

[81]  Y. Yeh,et al.  One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ions , 2015 .

[82]  Wei Dai,et al.  Highly thymine-dependent formation of fluorescent copper nanoparticles templated by ss-DNA , 2013, Nanotechnology.

[83]  Ben Zhong Tang,et al.  Aggregation-induced emission. , 2011, Chemical Society reviews.

[84]  J. Lee,et al.  Synthesis of highly fluorescent metal (Ag, Au, Pt, and Cu) nanoclusters by electrostatically induced reversible phase transfer. , 2011, ACS nano.

[85]  L. Abuhassan,et al.  Synthesis of bright photostable red luminescent Cu nanoparticles , 2011 .

[86]  Xiaoliang Zhang,et al.  Fabrication and characterization of Ag nanoparticles based on plasmid DNA as templates , 2011 .

[87]  Dalibor Jancik,et al.  Superparamagnetic maghemite nanoparticles from solid-state synthesis - their functionalization towards peroral MRI contrast agent and magnetic carrier for trypsin immobilization. , 2009, Biomaterials.

[88]  Chi Zhang,et al.  Rapid Sonochemical Synthesis of Luminescent and Paramagnetic Copper Nanoclusters for Bimodal Bioimaging , 2015 .

[89]  E. Wang,et al.  Stable Cu nanoclusters: from an aggregation-induced emission mechanism to biosensing and catalytic applications. , 2014, Chemical communications.