Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice.

[1]  P. Ganey,et al.  Complement Activation in Acetaminophen-Induced Liver Injury in Mice , 2012, Journal of Pharmacology and Experimental Therapeutics.

[2]  Rainer Bischoff,et al.  Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry. , 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3]  R. Pieters,et al.  Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  M. Giera,et al.  Protein digestion optimization for characterization of drug-protein adducts using response surface modeling. , 2011, Journal of chromatography. A.

[5]  W. Humphreys,et al.  In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation. , 2009, Chemical research in toxicology.

[6]  C. Ju.  The Role of Haptic Macrophages in Regulation of Idiosyncratic Drug Reactions , 2009, Toxicologic pathology.

[7]  Robert P Hanzlik,et al.  Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo. , 2008, Chemical research in toxicology.

[8]  J. Ozer,et al.  The current state of serum biomarkers of hepatotoxicity. , 2008, Toxicology.

[9]  P. Dansette,et al.  Identification of liver protein targets modified by tienilic acid metabolites using a two-dimensional Western blot-mass spectrometry approach , 2007 .

[10]  N. Vermeulen,et al.  Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  R. Tunca,et al.  Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. , 2007, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[12]  N. Vermeulen,et al.  Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin , 2007, Drug Metabolism and Disposition.

[13]  M. Azarkan,et al.  Affinity chromatography: a useful tool in proteomics studies. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[14]  T. Williams,et al.  Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. , 2006, Chemical research in toxicology.

[15]  J. Castell,et al.  Allergic hepatitis induced by drugs , 2006, Current opinion in allergy and clinical immunology.

[16]  Sui Yung Chan,et al.  Monitoring drug-protein interaction. , 2006, Clinica chimica acta; international journal of clinical chemistry.

[17]  S. Curry,et al.  Structural basis of the drug-binding specificity of human serum albumin. , 2005, Journal of molecular biology.

[18]  Qing Zhang,et al.  The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications , 2005, BMC Bioinformatics.

[19]  Wei Duan,et al.  Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance , 2005, Drug metabolism reviews.

[20]  R. Lathe,et al.  The individuality of mice , 2004, Genes, brain, and behavior.

[21]  Xidong Jin,et al.  Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. , 2004, Mutation research.

[22]  Shufeng Zhou.  Separation and detection methods for covalent drug-protein adducts. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[23]  Ron D. Appel,et al.  ExPASy: the proteomics server for in-depth protein knowledge and analysis , 2003, Nucleic Acids Res..

[24]  A. Burlingame,et al.  Identification of the Hepatic Protein Targets of Reactive Metabolites of Acetaminophen in Vivo in Mice Using Two-dimensional Gel Electrophoresis and Mass Spectrometry* , 1998, The Journal of Biological Chemistry.

[25]  Y. C. Kim,et al.  Temporal variation in hepatotoxicity and metabolism of acetaminophen in mice. , 1998, Toxicology.

[26]  D. Amacher.  Serum transaminase elevations as indicators of hepatic injury following the administration of drugs. , 1998, Regulatory toxicology and pharmacology : RTP.

[27]  E. Khairallah,et al.  Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase. , 1996, Toxicology and applied pharmacology.

[28]  J. Lin,et al.  Species similarities and differences in pharmacokinetics. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[29]  A. Singer,et al.  The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. , 1995, Annals of emergency medicine.

[30]  C. G. Edmonds,et al.  Tandem mass spectrometry of very large molecules: serum albumin sequence information from multiply charged ions formed by electrospray ionization. , 1991, Analytical chemistry.

[31]  R. Pannell,et al.  Chromatography of non-human albumins on Cibacron Blue-agarose. Application to the separation of albumin from rat alpha-fetoprotein. , 1979, Journal of chromatography.

[32]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.

[33]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. , 1973, The Journal of pharmacology and experimental therapeutics.

[34]  J. Ambroso,et al.  Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance. , 2007, Chemical research in toxicology.

[35]  M. Otagiri,et al.  A molecular functional study on the interactions of drugs with plasma proteins. , 2005, Drug metabolism and pharmacokinetics.

[36]  Kelvin H. Lee,et al.  Applications of affinity chromatography in proteomics. , 2004, Analytical biochemistry.

[37]  T. Baillie,et al.  Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. , 2004, Chemical research in toxicology.

[38]  Albert G. Hulst,et al.  Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin , 2002, Archives of Toxicology.

[39]  M. Festing,et al.  Genetic factors in toxicology: implications for toxicological screening. , 1987, Critical reviews in toxicology.

[40]  S. Thorgeirsson,et al.  Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. , 1974, Pharmacology.