Hypoprothrombinemia Associated with Cefoperazone Treatment

A patient with acute renal failure and gram-negative septicemia developed hypoprothrombinemia during treatment with cefoperazone. The coagulation defect was corrected by vitamin K administration. A multifactorial pathogenetic mechanism of vitamin K deficiency that developed during treatment with parenteral antibiotics is presented.

[1]  Scott Wietecha.  Prolonged bleeding times and bleeding diathesis associated with moxalactam administration , 1983 .

[2]  T. Russell,et al.  Coagulopathy associated with the use of moxalactam. , 1982, JAMA.

[3]  R. Holt,et al.  Hypoprothrombinemia Associated with Moxalactam Treatment of a Septic Sternoclavicular Arthritis Due to Citrobacter Diversus , 1981, Drug intelligence & clinical pharmacy.

[4]  R. Bailey,et al.  Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics. , 1980, The New Zealand medical journal.

[5]  C. W. Greenlaw,et al.  Hypoprothrombinemia Associated with Cefamandole , 1980 .

[6]  R. Daum,et al.  Cutaneous necrosis associated with intravenous nafcillin therapy. , 1980, American journal of diseases of children.

[7]  C. Hooper,et al.  GASTROINTESTINAL BLEEDING DUE TO VITAMIN K DEFICIENCY IN PATIENTS ON PARENTERAL CEFAMANDOLE , 1980, The Lancet.

[8]  Soothill Jf.  Letter: Immunoglobulin standards. , 1975 .

[9]  S. Nader.  Letter: Storage and transport of serum for prolactin radioimmunoassay. , 1974, Lancet.

[10]  A. Lubin,et al.  Letter: Coagulopathy with cefazolin in uremia. , 1974, The New England journal of medicine.

[11]  J. Hirsh,et al.  Unexpected vitamin K deficiency in hospitalized patients. , 1973, Canadian Medical Association journal.

[12]  M. Yudis,et al.  Bleeding problems with carbenicillin. , 1972, Lancet.

[13]  J. Ham.  HYPOPROTHROMBINAEMIA IN PATIENTS UNDERGOING PROLONGED INTENSIVE CARE , 1971, The Medical journal of Australia.

[14]  J. H. Ferguson,et al.  Bleeding tendency in uremia. , 1956, Blood.

[15]  K. Shimizu.  Cefoperazone: absorption, excretion, distribution, and metabolism. , 1980, Clinical therapeutics.

[16]  S. Mitsuhashi,et al.  In vitro and in vivo antibacterial activity of cefoperazone. , 1980, Clinical therapeutics.

[17]  J. Matsen,et al.  Bactericidal activity of cefoperazone in comparison with other beta-lactam antibiotics and gentamicin. , 1980, Clinical therapeutics.

[18]  F. Kayser.  Microbiological studies on cefoperazone. , 1980, Clinical therapeutics.

[19]  Kayser Fh.  Microbiological studies on cefoperazone. , 1980 .

[20]  S. Rabiner.  Bleeding in uremia. , 1972, The Medical clinics of North America.