The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours

[1]  K. Vousden,et al.  Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest , 1998, Molecular and Cellular Biology.

[2]  K. Hess,et al.  Human and murine high endothelial venule cells phagocytose apoptotic leukocytes. , 1997, Experimental cell research.

[3]  H. Hydén,et al.  A receptor for phosphatidylserine-speci ® c clearance of apoptotic cells , 2000 .

[4]  C. Haslett,et al.  Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. , 1992, Journal of immunology.

[5]  H. Pinedo,et al.  Mechanism of action of antitumor drug etoposide: a review. , 1988, Journal of the National Cancer Institute.

[6]  H. Horvitz,et al.  C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 , 1998, Nature.

[7]  H. Horvitz,et al.  The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters , 1998, Cell.

[8]  M. Raff,et al.  Programmed cell death and Bcl‐2 protection in the absence of a nucleus. , 1994, The EMBO journal.

[9]  Pier Paolo Pandolfi,et al.  Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies , 1998, Nature Genetics.

[10]  M. Luciani,et al.  ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells. , 1998, Biochemical Society transactions.

[11]  B. Barres,et al.  Programmed cell death and the control of cell survival: lessons from the nervous system. , 1993, Science.

[12]  Y. Hsu,et al.  Conformation of the Bax C‐terminus regulates subcellular location and cell death , 1999, The EMBO journal.

[13]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[14]  L. Dini,et al.  Phagocytosis of apoptotic bodies by liver endothelial cells. , 1995, Journal of cell science.

[15]  S. Gordon,et al.  Recognizing death: the phagocytosis of apoptotic cells. , 1998, Trends in cell biology.

[16]  K. Tada,et al.  Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. , 1982, Cancer research.

[17]  N. Hogg,et al.  Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis , 1990, Nature.

[18]  M. Raff,et al.  Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death , 1996, The Journal of cell biology.

[19]  A. Porter.  Protein translocation in apoptosis. , 1999, Trends in cell biology.

[20]  G. Evan,et al.  Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak , 1997, The Journal of cell biology.

[21]  L. Cheng,et al.  Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells. , 1995, Molecular biology of the cell.

[22]  S Gordon,et al.  Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  E. White,et al.  E1B 19,000-Molecular-Weight Protein Interacts with and Inhibits CED-4-Dependent, FLICE-Mediated Apoptosis , 1998, Molecular and Cellular Biology.

[24]  G. Gobe,et al.  Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Role of apoptosis. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[25]  J. Savill,et al.  Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases* , 1998, The Journal of Biological Chemistry.

[26]  J C Reed,et al.  Bax directly induces release of cytochrome c from isolated mitochondria. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Yannick Hamon,et al.  ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. , 2000, Nature Cell Biology.

[28]  J. Ahearn,et al.  C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. , 1997, Journal of immunology.

[29]  M. Raff,et al.  Constitutive expression of the machinery for programmed cell death , 1996, The Journal of cell biology.

[30]  M. Luciani,et al.  The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death. , 1996, The EMBO journal.

[31]  A. Wyllie,et al.  Macrophage recognition of cells undergoing programmed cell death (apoptosis). , 1985, Immunology.

[32]  A. Devitt,et al.  Human CD14 mediates recognition and phagocytosis of apoptotic cells , 1998, Nature.

[33]  E. White,et al.  Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. , 1993, Genes & development.

[34]  J Savill,et al.  Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. , 1992, The Journal of clinical investigation.

[35]  M. Hengartner,et al.  Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans , 1998, Cell.

[36]  J. Savill,et al.  Recognition and phagocytosis of cells undergoing apoptosis. , 1997, British medical bulletin.

[37]  Horvitz,et al.  Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. , 1991, Genetics.

[38]  V. Fadok,et al.  Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. , 1992, Journal of immunology.

[39]  Jean-Claude Martinou,et al.  Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis , 1999, The Journal of cell biology.

[40]  V. Dixit,et al.  Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex* , 1998, The Journal of Biological Chemistry.

[41]  G. Cohen,et al.  Dissociation of Phagocyte Recognition of Cells Undergoing Apoptosis from Other Features of the Apoptotic Program* , 1998, The Journal of Biological Chemistry.

[42]  A. Devitt,et al.  Macrophage recognition of ICAM-3 on apoptotic leukocytes. , 1999, Journal of immunology.

[43]  S. Korsmeyer,et al.  Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis , 1998, The EMBO journal.

[44]  S. Korsmeyer,et al.  Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death , 1993, Cell.

[45]  A. Levine,et al.  Surfing the p53 network , 2000, Nature.

[46]  A. Poggi,et al.  The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium. , 1997, European journal of immunology.

[47]  A. Rees,et al.  Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. , 1992, Kidney international.

[48]  P. Williamson,et al.  Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes , 1995, The Journal of experimental medicine.

[49]  P. Williamson,et al.  Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey , 1999, Nature Cell Biology.

[50]  Y. Lazebnik,et al.  Caspases: enemies within. , 1998, Science.

[51]  J. Hughes,et al.  Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. , 1994, The Journal of clinical investigation.

[52]  C. Haslett,et al.  Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. , 1994, Journal of immunology.

[53]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.

[54]  R. Silverstein,et al.  CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis , 1995, The Journal of experimental medicine.

[55]  S. Nagata,et al.  Lethal effect of the anti-Fas antibody in mice , 1993, Nature.