Increased frequency of the apolipoprotein E‐4 isoform in male subjects with multifactorial hypercholesterolemia

The apoE polymorphism was studied by two‐dimensional gel electrophoresis in serum samples from 62 male subjects with multifactorial hypercholesterolemia and from 63 normal subjects. The apoE‐4 isoform was significantly more frequent (p<0.02) among the hypercholesterolemic subjects than among the normocholesterolemic controls.

[1]  F. W. Robertson,et al.  Polymorphism at the Apoprotein‐E locus in relation to risk of coronary disease , 1984, Clinical genetics.

[2]  K. Berg,et al.  Low density lipoprotein receptors in cultured skin fibroblasts from psoriasis patients , 1984, Clinical genetics.

[3]  R. Mahley,et al.  The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. , 1983, The Journal of biological chemistry.

[4]  T. Kita,et al.  Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia. , 1983, The New England journal of medicine.

[5]  R. Mahley,et al.  Human apolipoprotein E. The complete amino acid sequence. , 1982, The Journal of biological chemistry.

[6]  R. Mahley,et al.  Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. , 1982, The Journal of biological chemistry.

[7]  I. Holme,et al.  EFFECT OF DIET AND SMOKING INTERVENTION ON THE INCIDENCE OF CORONARY HEART DISEASE Report from the Oslo Study Group of a Randomised Trial in Healthy Men , 1981, The Lancet.

[8]  I. Hjermann,et al.  EFFECT OF DIET AND SMOKING INTERVENTION ON THE INCIDENCE OF CORONARY HEART DISEASE , 1981 .

[9]  K. Berg,et al.  The apoE polymorphism studied by two‐dimensional, high‐resolution gel electrophoresis of serum , 1981, Clinical genetics.

[10]  R. Mahley,et al.  Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. , 1981, The Journal of biological chemistry.

[11]  J. Breslow,et al.  Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. , 1981, Biochemistry.

[12]  R. Mahley,et al.  Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process. , 1980, The Journal of biological chemistry.

[13]  I. Hjermann.  Smoking and diet intervention in healthy coronary high risk men. Methods and 5-year follow-up of risk factors in a randomized trial. The Oslo study. , 1980, Journal of the Oslo city hospitals.

[14]  R. Mahley,et al.  Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. , 1978, The Journal of biological chemistry.

[15]  N. Anderson,et al.  Analytical techniques for cell fractions. XXI. Two-dimensional analysis of serum and tissue proteins: multiple isoelectric focusing. , 1978, Analytical biochemistry.

[16]  N G Anderson,et al.  Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: multiple gradient-slab gel electrophoresis. , 1978, Analytical biochemistry.

[17]  M. Höök,et al.  Glycosaminoglycans and their binding to biological macromolecules. , 1978, Annual review of biochemistry.

[18]  N G Anderson,et al.  High resolution two-dimensional electrophoresis of human plasma proteins. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Mahley,et al.  Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. , 1977, The Journal of biological chemistry.

[20]  G. Utermann,et al.  Studies on the metabolic defect in Broad‐ß disease (hyperlipoproteinaemia type III) , 1977, Clinical genetics.

[21]  J. Goldstein,et al.  Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans , 1976, Cell.

[22]  H. Pownall,et al.  The interaction of human plasma glycoaminoglycans with plasma lipoproteins. , 1975 .

[23]  P. O’Farrell.  High resolution two-dimensional electrophoresis of proteins. , 1975, The Journal of biological chemistry.

[24]  R. Fleischmajer.  [Familial hyperlipoproteinemia]. , 1969, Anais brasileiros de dermatologia.