Does Evidence Of Inflammation On

Abslrtlct: 1lIu:1IgrofIrul: PretenD. delivery is the most common cause of neorudal morbidity and morlBlity in the United S1ates. There is evidence that cenicovaginal infectioo could predispose to preterm.Jabor. This study explored a possible associatioo of evidence of Inflammation on an otherwise normal Papanicolaou smear obtained during pregnancy with subsequent preterm labor and preterm. delivery. Metbods: Using a retrospective matched cohort design, we studied women who pve biJ1b to live singleton infants at the University of Missouri Hospi1al and Clinics during a 21-month period. Papanicolaou smears were obtained from 1 to 8 months before delivery and were interpreted in the same cytopadlology laboratory. Data pertaining to outcome variables and potential confounding wriables were collected from hospi1al charts. ReSflIts: Incidence rates were 14.4 percent for labor < 37 weeks' gestation (pretenD labor), 12.3 pen:ent for hospi1alization for preterm labor, 9.9 percent for delivery < 37 weeks (pretenD delivery), 2.6 percent for delivery < 34 weeks, and 7.5 percent for biJ1b weight < 2500 g. On uniwriate and muItmuiate aaaIyses, there were no significant dift'erences in any outcome between the 293 women with Inflammation and the 284 women without Inflammation 00 Papanicolaou smear. Results were unchanged when the llUllysis was limited to the 412 women who received no antibiotics during pregnanc:y. Among the 38 women with a history rI. pretenD. labor or pretenD. delivery, those with cenica1lnflfllllllUdion had a higher rate of preterm labor than those without Inflammation.

[1]  S. Cox,et al.  Infection and preterm labor. , 2000, Clinical obstetrics and gynecology.

[2]  R. Blake,et al.  Inflammation on the cervical Papanicolaou smear: the predictive value for infection in asymptomatic women. , 1992, Family medicine.

[3]  B. Calkins,et al.  Improved pregnancy outcome following successful treatment of chlamydial infection. , 1991, JAMA.

[4]  R. Lee,et al.  The Significance of Moderate and Severe Inflammation on Class I Papanicolaou Smear , 1990, Obstetrics and gynecology.

[5]  B. Calkins,et al.  Improved Pregnancy Outcome Following Successful Treatment of Chlamydial Infection , 1990 .

[6]  E. Davidson,et al.  Implications of inflammatory changes on cervical cytology. , 1990, BMJ.

[7]  H. Ehya,et al.  Detection of Chlamydia trachomatis in cervical smears from pregnant population. , 1990, Archives of pathology & laboratory medicine.

[8]  R. Gibbs,et al.  A Randomized, Blinded, Placebo‐Controlled Trial of Antibiotics in Idiopathic Preterm Labor , 1989, Obstetrics and gynecology.

[9]  B. Sibai,et al.  The incidence of positive amniotic fluid cultures in patients in preterm labor with intact membranes , 1989, American journal of obstetrics and gynecology.

[10]  W. Ledger.  Infection and Premature Labor , 1989, American journal of perinatology.

[11]  J. Hobbins,et al.  Infection in the pathogenesis of preterm labor. , 1988, Seminars in perinatology.

[12]  R. Romero,et al.  Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. , 1988, American journal of obstetrics and gynecology.

[13]  J. Iams,et al.  Prevention of preterm birth. , 1988, Seminars in perinatology.

[14]  K. Holmes,et al.  Relationships of Vaginal Lactobacillus species, Cervical Chlamydia trachomatis, and Bacterial Vaginosis to Preterm Birth , 1988, Obstetrics and gynecology.

[15]  D. Contos,et al.  Does extra-amniotic infection cause preterm labor? Gas-liquid chromatography studies of amniotic fluid in amnionitis, preterm labor, and normal controls. , 1987, Obstetrics and gynecology.

[16]  S. Weller,et al.  Prospective Evaluation of a Risk Scoring System for Predicting Preterm Delivery in Black Inner City Women , 1987, Obstetrics and gynecology.

[17]  K. Holmes,et al.  Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome. , 1986, JAMA.

[18]  K. Holmes,et al.  Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. , 1986, Obstetrics and gynecology.

[19]  S. Gabbe,et al.  Can preterm deliveries be prevented? , 1985, American journal of obstetrics and gynecology.

[20]  M C McCormick,et al.  The contribution of low birth weight to infant mortality and childhood morbidity. , 1985, The New England journal of medicine.

[21]  D. Guzick,et al.  The Association of Chorioamnionitis With Preterm Delivery , 1985, Obstetrics and gynecology.

[22]  S. Tischler.  Principles and Practice of Clinical Gynecology , 1984 .

[23]  N. Tejani,et al.  Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy. , 1984, American journal of obstetrics and gynecology.

[24]  R. Eden,et al.  Intra-amniotic bacterial colonization in premature labor. , 1984, American journal of obstetrics and gynecology.

[25]  J. Fortney,et al.  The development of an index of high-risk pregnancy. , 1982, American journal of obstetrics and gynecology.

[26]  L. S. James,et al.  Premature rupture of membranes, preterm delivery, and group B streptococcal colonization of mothers. , 1981, American journal of obstetrics and gynecology.

[27]  J. R. Bobitt,et al.  Amniotic fluid infection as determined by transabdominal amniocentesis in patients with intact membranes in premature labor. , 1981, American journal of obstetrics and gynecology.

[28]  L. Gluck,et al.  Premature Labor. II. Bacterial Sources of Phospholipase , 1981, Obstetrics and gynecology.

[29]  L. Keith,et al.  The Northwestern University multihospital twin study , 1980 .

[30]  G. Liggins,et al.  System for Predicting Spontaneous Preterm Birth , 1980, Obstetrics and gynecology.

[31]  M. Pupkin,et al.  Bacterial colonization of amniotic fluid from intact fetal membranes. , 1980, American journal of obstetrics and gynecology.

[32]  L. E. Edwards,et al.  Gonorrhea in pregnancy. , 1978, American journal of obstetrics and gynecology.

[33]  A. Feinstein.  Clinical biostatistics , 1974 .

[34]  I. Emeruwa.  A randomized study of antibiotic therapy in idiopathic preterm labor. , 1989, Obstetrics and gynecology.

[35]  R. H. Holbrook,et al.  Evaluation of a risk-scoring system for prediction of preterm labor. , 1989, American journal of perinatology.

[36]  L. Reller,et al.  Adjunctive erythromycin treatment for idiopathic preterm labor: results of a randomized, double-blinded, placebo-controlled trial. , 1986, American journal of obstetrics and gynecology.

[37]  B. Rosner,et al.  Genital mycoplasmas as a cause of excess premature delivery. , 1981, Transactions of the Association of American Physicians.

[38]  L. Keith,et al.  The Northwestern University multihospital twin study. I. A description of 588 twin pregnancies and associated pregnancy loss, 1971 to 1975. , 1980, American journal of obstetrics and gynecology.

[39]  M. Balogun.  Pelvic Infections. , 1938, California and western medicine.