Melittin inhibits tumor cell migration and enhances cisplatin sensitivity by suppressing IL‐17 signaling pathway gene LCN2 in castration‐resistant prostate cancer

Melittin is a small molecule polypeptide extracted from the abdominal cavity of bees, which is used to treat inflammatory diseases and relieve pain. However, the antitumor effect of melittin and its mechanisms remain unclear, especially in castration‐resistant prostate cancer (CRPC).

[1]  N. Jiang,et al.  Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer , 2022, Cell Death & Disease.

[2]  Y. Kuwahara,et al.  CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability. , 2022, Life sciences.

[3]  Rucheng Yan,et al.  Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer. , 2022, Cancer letters.

[4]  A. Jemal,et al.  Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.

[5]  R. Weiskirchen,et al.  Lipocalin-2 (LCN2) Deficiency Leads to Cellular Changes in Highly Metastatic Human Prostate Cancer Cell Line PC-3 , 2022, Cells.

[6]  Li Ma,et al.  A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis , 2021, Nature Communications.

[7]  A. Bansal,et al.  The m6A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis , 2021, Science Immunology.

[8]  J. K. Badawi.  Bee Venom Components as Therapeutic Tools against Prostate Cancer , 2021, Toxins.

[9]  T. H. van der Kwast,et al.  Prostate cancer , 2021, Nature Reviews Disease Primers.

[10]  Shih-Ying Wu,et al.  Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung , 2021, Nature Communications.

[11]  M. Staege,et al.  Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells , 2020, International journal of molecular sciences.

[12]  Fang Zuo,et al.  LCN2 Mediated by IL-17 Affects the Proliferation, Migration, Invasion and Cell Cycle of Gastric Cancer Cells by Targeting SLPI , 2020, Cancer management and research.

[13]  Henk G van der Poel,et al.  EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II-2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer. , 2020, European urology.

[14]  Diwei Ho,et al.  Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer , 2020, npj Precision Oncology.

[15]  P. Scheet,et al.  Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development. , 2020, American journal of respiratory and critical care medicine.

[16]  D. Pe’er,et al.  Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis , 2020, Science.

[17]  P. Vivas-Mejia,et al.  Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer , 2020, International journal of molecular sciences.

[18]  Q. Luo,et al.  Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response , 2020, Nature Communications.

[19]  G. Stark,et al.  Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis , 2020, Nature Communications.

[20]  R. Chen,et al.  Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3 , 2019, Cell Death & Disease.

[21]  P. Nelson,et al.  Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer. , 2019, The Journal of clinical investigation.

[22]  S. Gaffen,et al.  IL-17 receptor–based signaling and implications for disease , 2019, Nature Immunology.

[23]  Y. Kuwahara,et al.  CRISPR/Cas9-mediated knockout of Lcn2 effectively enhanced CDDP-induced apoptosis and reduced cell migration capacity of PC3 cells. , 2019, Life sciences.

[24]  H. Bae,et al.  Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide , 2019, Journal of Immunotherapy for Cancer.

[25]  Zhihong Zhang,et al.  Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis , 2019, Nature Communications.

[26]  G. Tonon,et al.  Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression , 2018, Nature Communications.

[27]  David F Jarrard,et al.  Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  H. Mukhtar,et al.  Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. , 2017, Cancer letters.

[29]  S. Yang,et al.  Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition , 2016, Oncogene.

[30]  H. Kashima,et al.  Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells , 2016, PloS one.

[31]  F. Separovic,et al.  Model Membrane and Cell Studies of Antimicrobial Activity of Melittin Analogues. , 2015, Current topics in medicinal chemistry.

[32]  V. Adam,et al.  Perspective of Use of Antiviral Peptides against Influenza Virus , 2015, Viruses.

[33]  J. Jonkers,et al.  IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis , 2015, Nature.

[34]  M. Rubin,et al.  Aggressive Variants of Castration-Resistant Prostate Cancer , 2014, Clinical Cancer Research.

[35]  T. Souto-Padrón,et al.  Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways. , 2013, Toxicon : official journal of the International Society on Toxinology.

[36]  P. Thall,et al.  Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer , 2013, Clinical Cancer Research.

[37]  H. Hudnell,et al.  Chronic biotoxin-associated illness: multiple-system symptoms, a vision deficit, and effective treatment. , 2005, Neurotoxicology and teratology.

[38]  Thomas,et al.  The Structure of Melittin , 2001 .

[39]  W. Shi,et al.  Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice , 2016, Applied Microbiology and Biotechnology.