The prevalence and predictors of metabolically healthy obesity in obese rural population of China: a cross-sectional study

Abstract Till now, no evidence illustrates the prevalence and predictors of metabolically healthy obesity (MHO) in rural areas of China. The objective of this study was, firstly, to examine the prevalence of MHO in rural areas of China, and identify contributing determinants of MHO, Secondly, to comprehensively investigate to the different characteristics between MHO and metabolically unhealthy obesity (MUO). We conducted a population-based cross-sectional study of 2037 participants with obesity in rural Liaoning Province during 2012–2013. Obesity was defined as BMI ≥28 kg/m2 and metabolically healthy was defined as not having the metabolic syndrome. The prevalence of MHO was 23.1%, and significantly decreased with advancing age in female group. However there was no significant tendency with advancing age in male group. Independent determinant factors for MHO were age <55 years (odds ratio [OR] 1.659; p = .001), non-current smoking (OR 1.397; p = .038), pre-menopause (OR 1.648; p = .030) and non-hyperuricemia (OR 2.317; p < .001), whereas race, gender, diet score, current drinking, marriage, sleep duration, hyperhomocysteinemia, levels of physical activity, annual income and educational status were not significant contributors. In conclusion, we found that age <55 years, non-current smoking, pre-menopause and non-hyperuricemia were identified as independent determinant factors for MHO in this population.

[1]  N. Nakamura,et al.  Metabolically healthy obesity and risk of incident CKD. , 2015, Clinical journal of the American Society of Nephrology : CJASN.

[2]  H. J. Yoo,et al.  Association between body size phenotype and sleep duration: Korean National Health and Nutrition Examination Survey V (KNHANES V). , 2015, Metabolism: clinical and experimental.

[3]  Y. Zhao,et al.  Association between metabolically unhealthy overweight/obesity and chronic kidney disease: the role of inflammation. , 2014, Diabetes & metabolism.

[4]  Lei Gong,et al.  Metabolic abnormalities, but not obesity, contribute to the mildly reduced eGFR in middle-aged and elderly Chinese , 2014, International Urology and Nephrology.

[5]  J. Lima,et al.  Metabolically-healthy obesity and coronary artery calcification. , 2014, Journal of the American College of Cardiology.

[6]  J. Chen,et al.  Metabolically healthy obesity and its associates in Mongolian Chinese adults. , 2014, Metabolic syndrome and related disorders.

[7]  P. Kearney,et al.  Defining Metabolically Healthy Obesity: Role of Dietary and Lifestyle Factors , 2013, PloS one.

[8]  A. Must,et al.  Physical Activity and Screen Time in Metabolically Healthy Obese Phenotypes in Adolescents and Adults , 2013, Journal of obesity.

[9]  C. Phillips Metabolically healthy obesity: Definitions, determinants and clinical implications , 2013, Reviews in Endocrine and Metabolic Disorders.

[10]  M. Qorbani,et al.  Metabolic syndrome and menopause , 2013, Journal of Diabetes & Metabolic Disorders.

[11]  T. Postolache,et al.  Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults , 2013, Obesity.

[12]  W. Drygas,et al.  Smoking status, the menopausal transition, and metabolic syndrome in women , 2012, Menopause.

[13]  C. Stefanadis,et al.  Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. , 2011, Journal of the American College of Cardiology.

[14]  F. Paccaud,et al.  Metabolically healthy obesity: different prevalences using different criteria , 2010, European Journal of Clinical Nutrition.

[15]  V. Messier,et al.  Identifying Metabolically Healthy but Obese Individuals in Sedentary Postmenopausal Women , 2010, Obesity.

[16]  E. Ingelsson,et al.  Impact of Body Mass Index and the Metabolic Syndrome on the Risk of Cardiovascular Disease and Death in Middle-Aged Men , 2010, Circulation.

[17]  C. Lavie,et al.  Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. , 2009, Journal of the American College of Cardiology.

[18]  Paul Poirier,et al.  Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism , 2006, Circulation.

[19]  R. Krauss,et al.  Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement , 2005, Current opinion in cardiology.

[20]  J. Tuomilehto,et al.  Joint effects of physical activity, body mass index, waist circumference and waist-to-hip ratio with the risk of cardiovascular disease among middle-aged Finnish men and women. , 2004, European heart journal.

[21]  D. Panagiotakos,et al.  Epidemiology of overweight and obesity in a Greek adult population: the ATTICA Study. , 2004, Obesity research.

[22]  Christopher,et al.  Diabetes and Cardiovascular Disease Outcomes in theMetabolically Healthy Obese Phenotype A cohort study , 2015 .

[23]  J. Mckenney,et al.  Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). , 2001, JAMA.