Transforming Growth Factor-β

[1]  A. Leask.  TGFβ, cardiac fibroblasts, and the fibrotic response , 2007 .

[2]  C. Kielty,et al.  Fibrillin-1 regulates the bioavailability of TGFβ1 , 2007, The Journal of cell biology.

[3]  C. Knabbe,et al.  TGF‐Beta Signaling in Breast Cancer , 2006, Annals of the New York Academy of Sciences.

[4]  N. Matsumoto,et al.  Recent progress in genetics of Marfan syndrome and Marfan-associated disorders , 2006, Journal of Human Genetics.

[5]  S. Jakowlew.  Transforming growth factor-β in cancer and metastasis , 2006, Cancer and Metastasis Reviews.

[6]  R. Serra,et al.  Tgfbr2 regulates the maintenance of boundaries in the axial skeleton. , 2006, Developmental biology.

[7]  T. Jardetzky,et al.  The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. , 2006, Reproduction.

[8]  D. Sheppard,et al.  Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. , 2006 .

[9]  K. Chihara,et al.  Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. , 2006, Endocrinology.

[10]  T. Turner,et al.  Additive enhancement of implant fixation following combined treatment with rhTGF-beta2 and rhBMP-2 in a canine model. , 2006, The Journal of bone and joint surgery. American volume.

[11]  W. B. van den Berg,et al.  TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7 , 2006, Arthritis research & therapy.

[12]  Xing Shen,et al.  Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. , 2006, Genes & development.

[13]  R. Ritchie,et al.  TGF-beta regulates the mechanical properties and composition of bone matrix. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Wolfram Kress,et al.  A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 , 2005, Nature Genetics.

[15]  D. Judge,et al.  Marfan's syndrome , 2005, The Lancet.

[16]  S. Fox,et al.  Current insights into the role of transforming growth factor-β in bone resorption , 2005, Molecular and Cellular Endocrinology.

[17]  D. Rifkin,et al.  Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1 , 2005 .

[18]  R. Derynck,et al.  SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .

[19]  Sophie Janssens,et al.  Transforming Growth Factor- 1 to the Bone , 2005 .

[20]  Dean Sheppard,et al.  Integrin-mediated activation of latent transforming growth factor β , 2005, Cancer and Metastasis Reviews.

[21]  Ji-shuai Zhang,et al.  Smad4 is required for the normal organization of the cartilage growth plate. , 2005, Developmental biology.

[22]  S. Shete,et al.  Mutations in Transforming Growth Factor-&bgr; Receptor Type II Cause Familial Thoracic Aortic Aneurysms and Dissections , 2005, Circulation.

[23]  R. Derynck,et al.  Repression of Runx2 function by TGF‐β through recruitment of class II histone deacetylases by Smad3 , 2005, The EMBO journal.

[24]  Malcolm N. Cooke,et al.  Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits. , 2005, Tissue engineering.

[25]  D. Rifkin,et al.  Osteopetrosis-like phenotype in latent TGF-β binding protein 3 deficient mice , 2005 .

[26]  F. Hoffmann,et al.  Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP , 2005, Oncogene.

[27]  S. Wientroub,et al.  Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment , 2005, Journal of Medical Genetics.

[28]  W. B. van den Berg,et al.  Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression. , 2005, Osteoarthritis and cartilage.

[29]  A. Rachmiel,et al.  Mandibular defect repair by TGF-beta and IGF-1 released from a biodegradable osteoconductive hydrogel. , 2005, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[30]  D. Rifkin.  Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability* , 2005, Journal of Biological Chemistry.

[31]  J. Chirgwin,et al.  Molecular mechanisms of breast cancer metastases to bone. , 2005, Clinical breast cancer.

[32]  Zuxiong Chen,et al.  Preferential production of latent transforming growth factor β‐2 by primary prostatic epithelial cells and its activation by prostate‐specific antigen , 2005, Journal of cellular physiology.

[33]  Wei Wu,et al.  MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. , 2005, Human molecular genetics.

[34]  A. Downing,et al.  Amino Acid Requirements for Formation of the TGF-β-Latent TGF-β Binding Protein Complexes , 2005 .

[35]  H. Moses,et al.  Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. , 2004, Developmental biology.

[36]  H. von Melchner,et al.  Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung , 2004, The Journal of cell biology.

[37]  Philippe Debeer,et al.  Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis , 2004, Nature Genetics.

[38]  Geoffrey D. Young,et al.  Molecular Interactions That Confer Latency to Transforming Growth Factor-β* , 2004, Journal of Biological Chemistry.

[39]  O. Fromigué,et al.  Growth factors and bone formation in osteoporosis: roles for fibroblast growth factor and transforming growth factor beta. , 2004, Current pharmaceutical design.

[40]  Wun-Jae Kim,et al.  Transforming Growth Factor-β Stimulates p300-dependent RUNX3 Acetylation, Which Inhibits Ubiquitination-mediated Degradation* , 2004, Journal of Biological Chemistry.

[41]  M. Oursler,et al.  Roles of stromal cell RANKL, OPG, and M‐CSF expression in biphasic TGF‐β regulation of osteoclast differentiation , 2004, Journal of cellular physiology.

[42]  D. Rifkin,et al.  Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 , 2004, The Journal of cell biology.

[43]  S. O'Kane,et al.  Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[44]  P. Dijke,et al.  New insights into TGF-β–Smad signalling , 2004 .

[45]  V. Kaartinen,et al.  Tgf-β3-induced palatal fusion is mediated by Alk-5/Smad pathway , 2004 .

[46]  J. Keski‐Oja,et al.  Latent TGF-β Binding Proteins: Extracellular Matrix Association and Roles in TGF-β Activation , 2004 .

[47]  Kim Henriksen,et al.  Transforming Growth Factor-β Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression* , 2003, Journal of Biological Chemistry.

[48]  Wei-zhong Chang,et al.  Runx2 Integrates Estrogen Activity in Osteoblasts* , 2003, Journal of Biological Chemistry.

[49]  Ying E. Zhang,et al.  Smad-dependent and Smad-independent pathways in TGF-β family signalling , 2003, Nature.

[50]  Xiao-Fan Wang,et al.  ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling , 2003, Science.

[51]  R. Kucherlapati,et al.  Hierarchical model of gene regulation by transforming growth factor β , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[53]  Toru Yamaguchi,et al.  Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage* , 2003, Journal of Biological Chemistry.

[54]  R. Weinberg,et al.  Heart and Liver Defects and Reduced Transforming Growth Factor β2 Sensitivity in Transforming Growth Factor β Type III Receptor-Deficient Embryos , 2003, Molecular and Cellular Biology.

[55]  D. Arking,et al.  Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome , 2003, Nature Genetics.

[56]  S. Ralston,et al.  Transforming Growth Factor-β1 Mutations in Camurati-Engelmann Disease Lead to Increased Signaling by Altering either Activation or Secretion of the Mutant Protein* , 2003, The Journal of Biological Chemistry.

[57]  C. Heldin,et al.  Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses* , 2003, The Journal of Biological Chemistry.

[58]  K. Miyazono,et al.  RUNX transcription factors as key targets of TGF-β superfamily signaling , 2003 .

[59]  D. Rifkin,et al.  Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein* , 2003, The Journal of Biological Chemistry.

[60]  Justin P. Annes,et al.  Making sense of latent TGFβ activation , 2003, Journal of Cell Science.

[61]  M. Matzuk,et al.  Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily , 2002 .

[62]  A. Boskey,et al.  Effects of transforming growth factor-beta deficiency on bone development: a Fourier transform-infrared imaging analysis. , 2002, Bone.

[63]  J. Ninomiya-Tsuji,et al.  Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis , 2002, Mechanisms of Development.

[64]  M. Karsdal,et al.  Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis* , 2002, The Journal of Biological Chemistry.

[65]  K. Chihara,et al.  Activations of ERK1/2 and JNK by Transforming Growth Factor β Negatively Regulate Smad3-induced Alkaline Phosphatase Activity and Mineralization in Mouse Osteoblastic Cells* , 2002, The Journal of Biological Chemistry.

[66]  J. Otte,et al.  Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. , 2002, Genes & development.

[67]  Ying E. Zhang,et al.  TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses , 2002 .

[68]  W. B. van den Berg,et al.  Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair , 2002, The Journal of Immunology.

[69]  Lynda F. Bonewald,et al.  Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts , 2002, The Journal of Biological Chemistry.

[70]  S. K. Zaidi,et al.  Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[71]  D. Heymann,et al.  Recent advances in TGF-β effects on chondrocyte metabolism , 2002 .

[72]  Su‐Li Cheng,et al.  Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-β in Normal Human Osteoblastic Cells* , 2002, The Journal of Biological Chemistry.

[73]  D. Sheppard,et al.  The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1 , 2002, The Journal of cell biology.

[74]  D. Rifkin,et al.  Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability , 2002, The Journal of cell biology.

[75]  M. Reiss,et al.  Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function. , 2002, The Journal of biological chemistry.

[76]  O. Suzuki,et al.  Implantation of octacalcium phosphate combined with transforming growth factor-beta1 enhances bone repair as well as resorption of the implant in rat skull defects. , 2001, Journal of biomedical materials research.

[77]  M. Karsdal,et al.  Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway* , 2001, The Journal of Biological Chemistry.

[78]  Xiao-Fan Wang,et al.  The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  R. Baron,et al.  Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. , 2001, Bone.

[80]  L. Attisano,et al.  The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling , 2001, Molecular and Cellular Endocrinology.

[81]  D. Sheppard.  Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. , 2001, Chest.

[82]  S. M. Sims,et al.  Transforming Growth Factor‐β Induces Osteoclast Ruffling and Chemotaxis: Potential Role in Osteoclast Recruitment , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[83]  A Mazars,et al.  c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[84]  V. Kaartinen,et al.  TGF-β3-induced Palatogenesis Requires Matrix Metalloproteinases , 2001 .

[85]  R. Derynck,et al.  TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation , 2001, The EMBO journal.

[86]  N. Niikawa,et al.  Domain-specific Mutations of a Transforming Growth Factor (TGF)-β1 Latency-associated Peptide Cause Camurati-Engelmann Disease Because of the Formation of a Constitutively Active Form of TGF-β1* , 2001, The Journal of Biological Chemistry.

[87]  C. Deng,et al.  TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage , 2001, The Journal of cell biology.

[88]  C. Bünger,et al.  Transforming growth factor-beta1 adsorbed to tricalciumphosphate coated implants increases peri-implant bone remodeling. , 2001, Biomaterials.

[89]  M. Kumegawa,et al.  Endogenous Production of TGF-β Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-κB Ligand and Macrophage-Colony- Stimulating Factor1 , 2000, The Journal of Immunology.

[90]  K. Miyazono,et al.  A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[91]  Ester Piek,et al.  Role of Transforming Growth Factor-β Signaling in Cancer , 2000 .

[92]  Juha Saharinen,et al.  Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β , 2000 .

[93]  Jeffrey Bonadio,et al.  Developmental Expression of Latent Transforming Growth Factor β Binding Protein 2 and Its Requirement Early in Mouse Development , 2000, Molecular and Cellular Biology.

[94]  R. Derynck,et al.  Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members* , 2000, The Journal of Biological Chemistry.

[95]  C. Deng,et al.  Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. , 2000, Cytokine & growth factor reviews.

[96]  J. Murphy-Ullrich,et al.  Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology , 2000 .

[97]  K. M. Mulder,et al.  Role of Ras and Mapks in TGFβ signaling , 2000 .

[98]  Kenneth M. Yamada,et al.  Integrin Dynamics and Matrix Assembly: Tensin-Dependent Translocation of α5β1 Integrins Promotes Early Fibronectin Fibrillogenesis , 2000 .

[99]  I. Stamenkovic,et al.  Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. , 2000, Genes & development.

[100]  L. Bonewald,et al.  Role of the Latent Transforming Growth Factor β–Binding Protein 1 in Fibrillin‐Containing Microfibrils in Bone Cells In Vitro and In Vivo , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[101]  H. Moses,et al.  Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription* , 1999, The Journal of Biological Chemistry.

[102]  D. Dumont,et al.  A murine model of hereditary hemorrhagic telangiectasia. , 1999, The Journal of clinical investigation.

[103]  C. Gatlin,et al.  TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF. , 1999, Biochemical and Biophysical Research Communications - BBRC.

[104]  T. Martin,et al.  Activated T lymphocytes support osteoclast formation in vitro. , 1999, Biochemical and biophysical research communications.

[105]  T. Martin,et al.  Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1. , 1999, Endocrinology.

[106]  R. Derynck,et al.  Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. , 1999, Development.

[107]  D. Goltzman,et al.  Protein kinase signalling pathways involved in the up-regulation of the rat alpha1(I) collagen gene by transforming growth factor beta1 and bone morphogenetic protein 2 in osteoblastic cells. , 1999, The Biochemical journal.

[108]  S. Kern,et al.  Transforming growth factor‐β responsiveness in DPC4/SMAD4‐null cancer cells , 1999 .

[109]  M. Ferguson,et al.  Pathogenesis of cleft palate in TGF-beta3 knockout mice. , 1999, Development.

[110]  P. ten Dijke,et al.  Localization of Smads, the TGF‐β Family Intracellular Signaling Components During Endochondral Ossification , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[111]  R. W. Cho,et al.  Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro. , 1999, Journal of craniofacial genetics and developmental biology.

[112]  J. Brinckmann,et al.  Ligand-induced downregulation of receptors for TGF-beta in human osteoblast-like cells from adult donors. , 1999, The Journal of endocrinology.

[113]  J. Taipale,et al.  Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. , 1999, Cytokine & growth factor reviews.

[114]  D. Gazit,et al.  Recombinant TGF‐β1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice , 1999, Journal of cellular biochemistry.

[115]  K. Miyazono,et al.  Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. , 1999, Science.

[116]  N. Kaminski,et al.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.

[117]  R Wieser,et al.  TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. , 1999, The Journal of clinical investigation.

[118]  Liliana Attisano,et al.  SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor , 1998, Cell.

[119]  K. Ikeda,et al.  Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells* , 1998, The Journal of Biological Chemistry.

[120]  J. Compston,et al.  Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone. , 1998, Bone.

[121]  A. Geiser,et al.  Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene. , 1998, Bone.

[122]  L. Wakefield,et al.  Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency , 1998, Nature Medicine.

[123]  R. Hynes,et al.  Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo , 1998, Cell.

[124]  E. Li,et al.  Smad2 role in mesoderm formation, left–right patterning and craniofacial development , 1998, Nature.

[125]  G. Stein,et al.  CBFa(AML/PEBP2)‐related elements in the TGF‐β type I receptor promoter and expression with osteoblast differentiation , 1998, Journal of cellular biochemistry.

[126]  P. P. Hu,et al.  Molecular Mechanisms of Transforming Growth Factor-β Signaling , 1998 .

[127]  C. Deng,et al.  The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[128]  D. Chang,et al.  Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid* , 1998, The Journal of Biological Chemistry.

[129]  A. Roberts.  Molecular and Cell Biology of TGF-β , 1998, Mineral and Electrolyte Metabolism.

[130]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[131]  K. Miyazono,et al.  Smad6 inhibits signalling by the TGF-β superfamily , 1997, Nature.

[132]  J. Eisman,et al.  Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo. , 1997, Molecular endocrinology.

[133]  G. Boivin,et al.  TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. , 1997, Development.

[134]  J. Wrana,et al.  The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling , 1997, Cell.

[135]  A. Hata,et al.  TGF-β signalling through the Smad pathway , 1997 .

[136]  D. Rifkin,et al.  Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β , 1997, The Journal of cell biology.

[137]  C. Sherr.  Cancer Cell Cycles , 1996, Science.

[138]  R. Beavis,et al.  Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1* , 1996, The Journal of Biological Chemistry.

[139]  U. Lerner,et al.  Transforming growth factor‐β stimulates bone resorption in neonatal mouse calvariae by a prostaglandin‐unrelated but cell proliferation‐dependent pathway , 1996 .

[140]  G. Mundy,et al.  Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β , 1996, Nature Medicine.

[141]  B F Boyce,et al.  Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. , 1996, The Journal of clinical investigation.

[142]  M. Centrella,et al.  Rapid Flux in Transforming Growth Factor-β Receptors on Bone Cells* , 1996, The Journal of Biological Chemistry.

[143]  M. Sporn,et al.  Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. , 1996, Biochemistry.

[144]  L. Bonewald,et al.  Characterization and regulation of the latent transforming growth factor‐β complex secreted by vascular pericytes , 1996, Journal of cellular physiology.

[145]  J. Taipale,et al.  Hepatocyte Growth Factor Releases Epithelial and Endothelial Cells from Growth Arrest Induced by Transforming Growth Factor-1 (*) , 1996, The Journal of Biological Chemistry.

[146]  Y. Takeuchi,et al.  Differentiation and Cell Surface Expression of Transforming Growth Factor- Receptors Are Regulated by Interaction with Matrix Collagen in Murine Osteoblastic Cells (*) , 1996, The Journal of Biological Chemistry.

[147]  J. Taipale,et al.  Association of the small latent transforming growth factor‐beta with an eight cysteine repeat of its binding protein LTBP‐1. , 1996, The EMBO journal.

[148]  R. Derynck,et al.  Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype , 1996, The Journal of cell biology.

[149]  K. Miyazono,et al.  Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor- Binding Protein with the Extracellular Matrix (*) , 1995, The Journal of Biological Chemistry.

[150]  K. Irie,et al.  Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.

[151]  M. Yin,et al.  Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[152]  V. Kaartinen,et al.  Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction , 1995, Nature Genetics.

[153]  M. Ferguson,et al.  Transforming growth factor–β3 is required for secondary palate fusion , 1995, Nature Genetics.

[154]  L. Bonewald,et al.  Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein , 1995, The Journal of cell biology.

[155]  R. Marcus,et al.  The bone mineral status of patients with marfan syndrome , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[156]  X. Holy,et al.  Systemic administration of transforming growth factor-beta 2 prevents the impaired bone formation and osteopenia induced by unloading in rats. , 1995, The Journal of clinical investigation.

[157]  J. Seyer,et al.  Identification of a chemotactic epitope in human transforming growth factor‐β1 spanning amino acid residues 368–374 , 1995, Journal of cellular physiology.

[158]  R. Ziegler,et al.  Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. , 1995, The Journal of clinical investigation.

[159]  G. Haines,et al.  Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. , 1995, Clinical immunology and immunopathology.

[160]  A. Pfeiffer,et al.  Regulation of Transforming Growth Factor β by Sex Steroids , 1995, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[161]  R. Kimble,et al.  Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. , 1995, Endocrinology.

[162]  V. Rosen,et al.  Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype , 1995, Molecular and cellular biology.

[163]  M. Matzuk.  Functional analysis of mammalian members of the transforming growth factor-β superfamily , 1995, Trends in Endocrinology & Metabolism.

[164]  R. Mecham,et al.  Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3) (*) , 1995, The Journal of Biological Chemistry.

[165]  M. Ferguson,et al.  Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion. , 1995, The International journal of developmental biology.

[166]  H. Krutzsch,et al.  Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1 (*) , 1995, The Journal of Biological Chemistry.

[167]  J. Taipale,et al.  Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells (*) , 1995, The Journal of Biological Chemistry.

[168]  Y. Takeuchi,et al.  Relationship between actions of transforming growth factor (TGF)‐β and cell surface expression of its receptors in clonal osteoblastic cells , 1995, Journal of cellular physiology.

[169]  K. Miyazono,et al.  Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. , 1994, The Journal of biological chemistry.

[170]  T Matsumoto,et al.  Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity. , 1994, The Journal of biological chemistry.

[171]  K. Korach.  Insights from the study of animals lacking functional estrogen receptor. , 1994, Science.

[172]  V. Rosen,et al.  Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713] , 1994, The Journal of cell biology.

[173]  R. Derynck.  TGF-β-receptor-mediated signaling , 1994 .

[174]  L. Bonewald,et al.  Latent transforming growth factor-beta is produced by chondrocytes and activated by extracellular matrix vesicles upon exposure to 1,25-(OH)2D3. , 1994, The Journal of biological chemistry.

[175]  K. Korach,et al.  Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. , 1994, The New England journal of medicine.

[176]  M. Sporn,et al.  Role for autocrine TGF‐β1 in regulating differentiation of a human leukemic cell line toward osteoclast‐like cells , 1994, Journal of cellular physiology.

[177]  Jeffrey L. Wrana,et al.  Mechanism of activation of the TGF-β receptor , 1994, Nature.

[178]  Lynda F. Bonewald,et al.  Role of active and latent transforming growth factor β in bone formation , 1994 .

[179]  J. Lotem,et al.  The Network of Hematopoietic Cytokines , 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[180]  M. Sporn,et al.  Maternal rescue of transforming growth factor-beta 1 null mice. , 1994, Science.

[181]  S. Ralston.  Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[182]  J. Massagué,et al.  TGF-beta receptors and actions. , 1994, Biochimica et biophysica acta.

[183]  K. Miyazono,et al.  Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[184]  S. Miller,et al.  Systemic administration of recombinant transforming growth factor beta 2 (rTGF-beta 2) stimulates parameters of cancellous bone formation in juvenile and adult rats. , 1994, Bone.

[185]  M. Oursler.  Osteoclast synthesis and secretion and activation of latent transforming growth factor β , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[186]  L. Bonewald,et al.  Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. , 1994, The Journal of biological chemistry.

[187]  R. Mecham,et al.  Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices , 1994, The Journal of cell biology.

[188]  L. Peltonen,et al.  A novel mutation of the fibrillin gene causing ectopia lentis. , 1994, Genomics.

[189]  J. Wozney,et al.  Transforming Growth Factor-β Gene Family Members and Bone* , 1994 .

[190]  K. Miyazono,et al.  Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein , 1994, The Journal of cell biology.

[191]  H. Kawaguchi,et al.  Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. , 1993, The Journal of biological chemistry.

[192]  E. Allan,et al.  Plasminogen‐dependent activation of latent transforming growth factor beta (TGFβ) by growing cultures of osteoblast‐like cells , 1993, Journal of cellular physiology.

[193]  K. Miyazono,et al.  Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor , 1993, Cell.

[194]  B. Riggs,et al.  Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells. , 1993, Endocrinology.

[195]  J. Rosenbloom,et al.  Extracellular matrix 4: The elastic fiber , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[196]  Y. Higami,et al.  In vivo effects of transforming growth factor-β2 in ovariectomized rats , 1993 .

[197]  P. Weissberg,et al.  Tamoxifen decreases the rate of proliferation of rat vascular smooth-muscle cells in culture by inducing production of transforming growth factor beta. , 1993, The Biochemical journal.

[198]  J. Massagué,et al.  Betaglycan presents ligand to the TGFβ signaling receptor , 1993, Cell.

[199]  K. Miyazono,et al.  Lack of the latent transforming growth factor beta binding protein in malignant, but not benign prostatic tissue. , 1993, Cancer research.

[200]  A. Kulkarni,et al.  Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. , 1993, The American journal of pathology.

[201]  R. Derynck,et al.  Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. , 1993, Science.

[202]  D. Rifkin,et al.  Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells , 1993, Journal of cellular physiology.

[203]  Theresa L. Chen,et al.  Recombinant human transforming growth factor β1 modulates bone remodeling in a mineralizing bone organ culture , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[204]  W. Bursch,et al.  Transforming growth factor-beta 1 as a signal for induction of cell death by apoptosis. , 1993, British Journal of Cancer.

[205]  K. Miyazono,et al.  Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells , 1993, The Journal of cell biology.

[206]  R. Derynck,et al.  Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. , 1993, Molecular endocrinology.

[207]  D. Brenner,et al.  Transforming growth factor‐β1: There is regulation beyond transcription , 1993 .

[208]  L. Demers,et al.  Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[209]  E. Ruoslahti,et al.  Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease , 1992, Nature.

[210]  G. Roodman,et al.  Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. , 1992, Endocrinology.

[211]  G. Proetzel,et al.  Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.

[212]  J. Aubin,et al.  Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor beta. , 1992, Bone and mineral.

[213]  J. Massagué,et al.  Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. , 1992, The Journal of biological chemistry.

[214]  D. Rifkin,et al.  Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity , 1992, The Journal of cell biology.

[215]  G. Gibbons,et al.  Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. , 1992, The Journal of clinical investigation.

[216]  M. Sporn,et al.  Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment. , 1992, Cancer research.

[217]  D. Davies,et al.  Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. , 1992, Science.

[218]  M. Hoffman.  Researchers get a first look at the versatile TGF-beta family. , 1992, Science.

[219]  M. Sporn,et al.  Post-transcriptional regulation of the human transforming growth factor-beta 1 gene. , 1992, The Journal of biological chemistry.

[220]  D. Rowley,et al.  Glucocorticoid regulation of transforming growth factor-beta activation in urogenital sinus mesenchymal cells. , 1992, Endocrinology.

[221]  J. Massagué.  Receptors for the TGF-β family , 1992, Cell.

[222]  D. Burt,et al.  Correction: a new interpretation of a chicken transforming growth factor-beta 4 complementary DNA. , 1992, Molecular endocrinology.

[223]  L. Bonewald,et al.  Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63). , 1992, The Journal of biological chemistry.

[224]  R B Mazess,et al.  Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. , 1992, The New England journal of medicine.

[225]  R. Weinberg,et al.  Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase , 1992, Cell.

[226]  S. Schultz-Cherry,et al.  Transforming growth factor-beta complexes with thrombospondin. , 1992, Molecular biology of the cell.

[227]  Broulík Pd.  Tamoxifen prevents bone loss in ovariectomized mice. , 1991 .

[228]  R. Weinberg,et al.  Expression cloning and characterization of the TGF-β type III receptor , 1991, Cell.

[229]  E. Amento,et al.  Rapid publication TGF‐β1 induces bone closure of skull defects , 1991 .

[230]  E. Canalis,et al.  Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone , 1991, Molecular and cellular biology.

[231]  B. Riggs,et al.  Avian osteoclasts as estrogen target cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[232]  Ada Hamosh,et al.  Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene , 1991, Nature.

[233]  R. Glanville,et al.  Partial sequence of a candidate gene for the Marfan syndrome , 1991, Nature.

[234]  M. Mattei,et al.  Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes , 1991, Nature.

[235]  L. Mathews,et al.  Expression cloning of an activin receptor, a predicted transmembrane serine kinase , 1991, Cell.

[236]  L. Bonewald,et al.  Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ , 1991 .

[237]  S. Mohan,et al.  Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[238]  K. Miyazono,et al.  A role of the latent TGF‐beta 1‐binding protein in the assembly and secretion of TGF‐beta 1. , 1991, The EMBO journal.

[239]  E. Burger,et al.  Inhibiting and stimulating effects of TGF‐β1 on osteoclastic bone resorption in fetal mouse bone organ cultures , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[240]  G. Hattersley,et al.  Effects of transforming growth factor β1 on the regulation of osteoclastic development and function , 1991 .

[241]  J. Dasch,et al.  IgG-stimulated and LPS-stimulated monocytes elaborate transforming growth factor type β (TGF-β) in active form , 1991 .

[242]  M. Sporn,et al.  Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription. , 1990, The Journal of biological chemistry.

[243]  V. Jordan,et al.  Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro. , 1990, Molecular pharmacology.

[244]  K. Yamaguchi,et al.  Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[245]  G. Mundy,et al.  In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice , 1990 .

[246]  A. Fontana,et al.  Sequence analysis of the promoter region of the glioblastoma derived T cell suppressor factor / transforming growth factor (TGF)-β2 gene reveals striking differences to the TGF-β1 and -β3 genes , 1990 .

[247]  M. Sporn,et al.  Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. , 1990, British Journal of Cancer.

[248]  R. Ziegler,et al.  Chemotactic response of osteoblastlike cells to transforming growth factorβ , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[249]  D. Rifkin,et al.  Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self- regulating system , 1990, The Journal of cell biology.

[250]  L. Gentry,et al.  The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor. , 1990, Biochemistry.

[251]  K. Miyazono,et al.  TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences , 1990, Cell.

[252]  L. Bonewald,et al.  Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts. , 1990, Endocrinology.

[253]  M E Bolander,et al.  Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur , 1990, The Journal of cell biology.

[254]  M. Lotz,et al.  Transforming growth factor-beta and cellular immune responses in synovial fluids. , 1990, Journal of immunology.

[255]  F. Ruscetti,et al.  γ‐Interferon‐Induced Activation of Latent Transforming Growth Factor‐β by Human Monocytes , 1990 .

[256]  J. Massagué,et al.  TGF‐β Receptors and TGF‐β Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties , 1990 .

[257]  H. Moses,et al.  Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin , 1990, The Journal of cell biology.

[258]  A. Waage,et al.  Regulation of interleukin-2 and interleukin-6 production from T-cells: Involvement of interleukin-1 β and transforming growth factor-β , 1990 .

[259]  R. Glanville,et al.  Connective tissue microfibrils. Isolation and characterization of three large pepsin-resistant domains of fibrillin. , 1989, The Journal of biological chemistry.

[260]  R. Derynck,et al.  Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2 , 1989 .

[261]  M. Sporn,et al.  Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. , 1989, Cell regulation.

[262]  M. Sporn,et al.  Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. , 1989, Journal of immunology.

[263]  J. Aubin,et al.  Effects of transforming growth factor β and epidermal growth factor on cell proliferation and the formation of bone nodules in isolated fetal rat calvaria cells , 1989 .

[264]  D. Rifkin,et al.  Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture , 1989, The Journal of cell biology.

[265]  M. Noda,et al.  In vivo stimulation of bone formation by transforming growth factor-beta. , 1989, Endocrinology.

[266]  L. Bonewald,et al.  Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. , 1989, Biochemical and biophysical research communications.

[267]  P. Segarini,et al.  Binding of transforming growth factor-beta to cell surface proteins varies with cell type. , 1989, Molecular endocrinology.

[268]  M. Sporn,et al.  Characterization of the promoter region of the human transforming growth factor-beta 1 gene. , 1989, The Journal of biological chemistry.

[269]  E. Canalis,et al.  Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[270]  B. Komm,et al.  Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. , 1988, Science.

[271]  Kenneth G. Mann,et al.  Evidence of estrogen receptors in normal human osteoblast-like cells , 1988 .

[272]  K. Miyazono,et al.  Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. , 1988, The Journal of biological chemistry.

[273]  H. Moses,et al.  Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium , 1988, The Journal of cell biology.

[274]  I A Silver,et al.  Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. , 1988, Experimental cell research.

[275]  A. Roberts,et al.  Membrane binding characteristics of two forms of transforming growth factor-beta. , 1987, The Journal of biological chemistry.

[276]  R. Turner,et al.  Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[277]  L M Wakefield,et al.  Distribution and modulation of the cellular receptor for transforming growth factor-beta , 1987, The Journal of cell biology.

[278]  M. Sporn,et al.  Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro , 1987, The Journal of cell biology.

[279]  G. Mundy,et al.  Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[280]  B. Komm,et al.  Estrogen Regulation of α1(I)-Procollagen Messenger Ribonucleic Acid in the Rat Uterus* , 1987 .

[281]  E. Engvall,et al.  Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils , 1986, The Journal of cell biology.

[282]  J. Massagué,et al.  Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae. , 1986, Endocrinology.

[283]  G. Rodan,et al.  Type-β transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells , 1986 .

[284]  J. Massagué,et al.  Cellular distribution of type I and type II receptors for transforming growth factor-beta. , 1986, The Journal of biological chemistry.

[285]  D. Lawrence,et al.  Beta-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex. , 1986, Biochemical and biophysical research communications.

[286]  D. Lawrence,et al.  Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions , 1985 .

[287]  R. Derynck,et al.  Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[288]  L. Bonewald,et al.  Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long‐term cultures of fetal rat calvarial osteoblasts , 1994 .

[289]  A. Moustakas,et al.  Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer , 2007 .

[290]  R. Jilka,et al.  Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo , 2005, Osteoporosis International.

[291]  D. Rifkin,et al.  Latent TGF-β binding proteins , 2005 .

[292]  M. Reiss,et al.  Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. , 2004, The Journal of biological chemistry.

[293]  B. Boyan,et al.  The First Stage of Transforming Growth Factor β1 Activation is Release of the Large Latent Complex from the Extracellular Matrix of Growth Plate Chondrocytes by Matrix Vesicle Stromelysin-1 (MMP-3) , 2001, Calcified Tissue International.

[294]  J. Chirgwin,et al.  Molecular mechanisms of tumor-bone interactions in osteolytic metastases. , 2000, Critical reviews in eukaryotic gene expression.

[295]  L. Bonewald.  Regulation and regulatory activities of transforming growth factor beta. , 1999, Critical reviews in eukaryotic gene expression.

[296]  D. Dickinson,et al.  TGF-beta1 is essential for the homeostasis of the dentin-pulp complex. , 1998, European journal of oral sciences.

[297]  J. Rossant,et al.  The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. , 1998, Genes & development.

[298]  M. Sporn,et al.  Mutational analysis of a transforming growth factor-beta receptor binding site. , 1998, Growth factors.

[299]  L. Bonewald,et al.  Effects of Retinol on Activation of Latent Transforming Growth Factor-β by Isolated Osteoclasts. , 1997, Endocrinology.

[300]  G. Boivin,et al.  Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice. , 1995, The American journal of pathology.

[301]  D. Williams,et al.  Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. , 1994, The Journal of clinical investigation.

[302]  K. Miyazono,et al.  Immunoelectron Microscopic Localization of Transforming Growth Factor β1 and Latent Transforming Growth Factor β1 Binding Protein in Human Gastrointestinal Carcinomas: Qualitative Difference between Cancer Cells and Stromal Cells , 1993 .

[303]  M. Reiss,et al.  Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis. , 1993, Critical reviews in oncogenesis.

[304]  A. Mauviel,et al.  Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. , 1993, Arthritis and rheumatism.

[305]  Bruce Ag,et al.  Transforming growth factor-beta accelerates osteoinduction in a craniofacial onlay model. , 1993 .

[306]  P. Byers,et al.  Marfan syndrome: defective synthesis, secretion, and extracellular matrix formation of fibrillin by cultured dermal fibroblasts. , 1992, The Journal of clinical investigation.

[307]  J. Wergedal,et al.  Differentiation of normal human bone cells by transforming growth factor-beta and 1,25(OH)2 vitamin D3. , 1992, Metabolism: clinical and experimental.

[308]  W. Bursch,et al.  Cell death by apoptosis and its protective role against disease. , 1992, Trends in pharmacological sciences.

[309]  E. Mackie,et al.  Stimulation of bone formation in vivo by transforming growth factor-beta: remodeling of woven bone and lack of inhibition by indomethacin. , 1990, Bone.

[310]  E. Canalis,et al.  Transforming Growth Factor-β Stimulates Bone Matrix Apposition and Bone Cell Replication in Cultured Fetal Rat Calvariae* , 1990 .

[311]  G. Rodan,et al.  Estradiol enhances insulin-like growth factor I mRNA and has anabolic effects in osteoblastic cells from rat calvariae and long bones , 1990 .

[312]  M. Bolander,et al.  Estrogen receptor mRNA expression during fracture healing in the rat detected by polymerase chain reaction amplification , 1990 .

[313]  M. Sporn,et al.  Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. , 1990, Growth factors.

[314]  M. Bolander,et al.  Transforming growth factor-beta in the regulation of fracture repair. , 1990, The Orthopedic clinics of North America.

[315]  G. Rodan,et al.  Type beta transforming growth factor regulates expression of genes encoding bone matrix proteins. , 1989, Connective tissue research.

[316]  P. A. Lucas.  Chemotactic response of osteoblast-like cells to transforming growth factor beta. , 1989, Bone.

[317]  M. Sporn,et al.  Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. , 1988, Recent progress in hormone research.