Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis.

[1]  Giorgio Saracco,et al.  The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study , 2011, Hepatology.

[2]  Chien-Jen Chen,et al.  Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma. , 2011, Gastroenterology.

[3]  Daniel L. Kastner,et al.  Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) , 2011, The Journal of experimental medicine.

[4]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[5]  S. Ryter,et al.  Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.

[6]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[7]  Peter C Dedon,et al.  Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates , 2010, International journal of cancer.

[8]  N. Hayashi,et al.  The Bcl‐xL inhibitor, ABT‐737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib , 2010, Hepatology.

[9]  I. Leray,et al.  ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response , 2010, Cell Death and Differentiation.

[10]  J. Opferman,et al.  Hepatocyte‐specific deletion of the antiapoptotic protein myeloid cell leukemia‐1 triggers proliferation and hepatocarcinogenesis in mice , 2010, Hepatology.

[11]  疋田 隼人.  Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver , 2010 .

[12]  V. Castranova,et al.  JNK1, a potential therapeutic target for hepatocellular carcinoma. , 2009, Biochimica et biophysica acta.

[13]  L. Hennighausen,et al.  BH3‐only protein bid participates in the Bcl‐2 network in healthy liver cells , 2009, Hepatology.

[14]  J. Everhart,et al.  Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. , 2009, Gastroenterology.

[15]  Rajagopal N. Aravalli,et al.  Molecular mechanisms of hepatocellular carcinoma , 2008, Hepatology.

[16]  V. Duronio,et al.  An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation. , 2008, Molecular biology of the cell.

[17]  G. Gores,et al.  Cellular and molecular mechanisms of liver injury. , 2008, Gastroenterology.

[18]  E. Tsochatzis,et al.  Serum apoptotic caspase activity as a marker of severity in HBeAg-negative chronic hepatitis B virus infection , 2007, Gut.

[19]  David Hecht,et al.  Oral IDN‐6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C , 2007, Hepatology.

[20]  Jordi Muntané,et al.  Mecanismos de lesión hepatocelular , 2007 .

[21]  M. Dewhirst,et al.  Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. , 2006, Cancer research.

[22]  Lisa M Yerian,et al.  In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease , 2006, Hepatology.

[23]  David A. Brenner,et al.  Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways , 2006 .

[24]  M. Peck-Radosavljevic,et al.  Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy. , 2006, Journal of hepatology.

[25]  R. Schwabe,et al.  Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[26]  P. Galle,et al.  Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. , 2006, International journal of oncology.

[27]  Lin Chen,et al.  Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. , 2005, Genes & development.

[28]  U. Mihm,et al.  Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C , 2005, Journal of viral hepatitis.

[29]  V. Duronio,et al.  A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1. , 2005, The Biochemical journal.

[30]  Michael Karin,et al.  Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases , 2005, Cell.

[31]  Takahiro Suzuki,et al.  Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. , 2004, Gastroenterology.

[32]  Y. Ben-Neriah,et al.  NF-κB functions as a tumour promoter in inflammation-associated cancer , 2004, Nature.

[33]  S. Matsuda,et al.  Prognostic significance of Bcl-xL in human hepatocellular carcinoma. , 2004, Surgery.

[34]  Rinat Abramovitch,et al.  NF-kappaB functions as a tumour promoter in inflammation-associated cancer. , 2004, Nature.

[35]  G. Gores,et al.  Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. , 2003, Gastroenterology.

[36]  S. Friedman,et al.  Expression and role of Bcl‐xL in human hepatocellular carcinomas , 2001, Hepatology.

[37]  E. Yeh,et al.  Regulation of Apoptosis and Cell Cycle Progression by MCL1 , 2000, The Journal of Biological Chemistry.

[38]  K. Roth,et al.  Mcl-1 deficiency results in peri-implantation embryonic lethality. , 2000, Genes & development.

[39]  N. Hayashi,et al.  Interleukin 1beta protects mice from Fas-mediated hepatocyte apoptosis and death. , 1999, Gastroenterology.

[40]  Yoshiharu Matsuura,et al.  The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice , 1998, Nature Medicine.

[41]  伊藤 善基.  Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma , 1998 .

[42]  N. Hayashi,et al.  Fas antigen expression in liver tissues of patients with chronic hepatitis B. , 1996, Journal of hepatology.

[43]  al. et,et al.  Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice , 1995, Science.

[44]  N. Hayashi,et al.  Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C , 1993, Hepatology.