Preventive effects of a synthetic absorbable antiadhesive film (seprafilm) on small bowel obstruction in patients who underwent elective surgery for colon cancer: A randomized controlled trial

Seprafilm did not decrease small bowel obstruction (SBO), but significantly decreased reoperation in patients with inflammatory bowel disease. However, the preventive effect in colon cancer remains unclear.

[1]  M. Stommel,et al.  Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis , 2014, The Lancet.

[2]  J. Jeekel,et al.  Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis , 2013, BMJ.

[3]  K. Slim,et al.  Post-operative adhesions after digestive surgery: their incidence and prevention: review of the literature. , 2012, Journal of visceral surgery.

[4]  M. Meurisse,et al.  Pathophysiology and prevention of postoperative peritoneal adhesions. , 2011, World journal of gastroenterology.

[5]  Qiyu Zhang,et al.  Efficacy and Safety of Seprafilm for Preventing Postoperative Abdominal Adhesion: Systematic Review and Meta-analysis , 2007, World Journal of Surgery.

[6]  E. Weiss,et al.  Does sodium hyaluronate- and carboxymethylcellulose-based bioresorbable membrane (Seprafilm) decrease operative time for loop ileostomy closure? , 2006, Techniques in Coloproctology.

[7]  A. Darzi,et al.  Reduction in Adhesive Small-Bowel Obstruction by Seprafilm® Adhesion Barrier After Intestinal Resection , 2006, Diseases of the colon and rectum.

[8]  C. Miki,et al.  Efficacy of Seprafilm for reducing reoperative risk in pediatric surgical patients undergoing abdominal surgery. , 2005, Journal of pediatric surgery.

[9]  Z. Cohen,et al.  Prevention of Postoperative Abdominal Adhesions by a Novel, Glycerol/Sodium Hyaluronate/Carboxymethylcellulose-Based Bioresorbable Membrane: A Prospective, Randomized, Evaluator-Blinded Multicenter Study , 2005, Diseases of the colon and rectum.

[10]  H. Ikeuchi,et al.  Bioresorbable Hyaluronate-Carboxymethylcellulose Membrane (Seprafilm) in Surgery for Rectal Carcinoma: A Prospective Randomized Clinical Trial , 2005, Surgery Today.

[11]  C. Tang,et al.  Bioresorbable Adhesion Barrier Facilitates Early Closure of the Defunctioning Ileostomy After Rectal Excision: A Prospective, Randomized Trial , 2003 .

[12]  Yoichi Tanaka,et al.  Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years. , 2003, Hepato-gastroenterology.

[13]  C. Tang,et al.  Bioresorbable Adhesion Barrier Facilitates Early Closure of the Defunctioning Ileostomy After Rectal Excision , 2003, Diseases of the colon and rectum.

[14]  Joel O. Johnson,et al.  Methods for decreasing postoperative gut dysmotility. , 2003, The Lancet. Oncology.

[15]  J. Connor,et al.  Comparison of a Novel Liquid (Adcon-P®) and a Sodium Hyaluronate and Carboxymethylcellulose Membrane (Seprafilm™) in Postsurgical Adhesion Formation in a Murine Model , 2003, Diseases of the colon and rectum.

[16]  L. Stassen,et al.  Fewer Intraperitoneal Adhesions With Use of Hyaluronic Acid–Carboxymethylcellulose Membrane: A Randomized Clinical Trial , 2002, Annals of surgery.

[17]  J. Jeekel,et al.  Glove powder promotes adhesion formation and facilitates tumour cell adhesion and growth , 2001, The British journal of surgery.

[18]  C. Pashos,et al.  Incidence of small-bowel obstruction and adhesiolysis after open colorectal and general surgery , 1999, Diseases of the colon and rectum.

[19]  M. Diamond,et al.  Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group. , 1996, Fertility and sterility.

[20]  S. Stryker,et al.  Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. , 1996, Journal of the American College of Surgeons.