Two recently approved in vivo Genotoxicity test guidelines
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A. TITLE OF THE TEST GUIDELINES (YEAR OF ORIGINAL ADOPTION, YEAR OF UPDATE) Transgenic rodent (TGR) somatic and germ cell gene mutation assays, EU: B.58, OECD: 488 (2011, 2013) In vivo mammalian alkaline comet assay, EU: none at present, OECD: 489 (2014) Note: the latest version of the OECD test guideline (TG) should always be used independent of whether it is published in the EU Test Method Regulation or not.