ras and GAP—Who's controlling whom?

Etat actuel des connaissances sur l'interaction moleculaire entre les proteines GAP et RAS et ses implications dans l'activation metabolique de la GTPase

[1]  M. Wigler,et al.  Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein , 1990, Cell.

[2]  Irving S. Sigal,et al.  Cloning of bovine GAP and its interaction with oncogenic ras p21 , 1988, Nature.

[3]  C. Marshall,et al.  The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product , 1988, Nature.

[4]  G. A. Martin,et al.  Molecular cloning of two types of GAP complementary DNA from human placenta. , 1988, Science.

[5]  D. Morrison,et al.  PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex , 1990, Cell.

[6]  M. Nakafuku,et al.  S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein , 1990, Cell.

[7]  C. Yu,et al.  The effect of GTPase activating protein upon ras is inhibited by mitogenically responsive lipids. , 1989, Science.

[8]  A. Wolfman,et al.  A cytosolic protein catalyzes the release of GDP from p21ras. , 1990, Science.

[9]  F. McCormick,et al.  A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. , 1987, Science.

[10]  D. Lowy,et al.  Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. , 1988, Science.

[11]  Masayuki Yamamoto,et al.  Homologous activators of ras in fission and budding yeast , 1990, Nature.

[12]  H. Kung,et al.  A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins , 1990, FEBS letters.

[13]  James R. Broach,et al.  SRV2, a gene required for RAS activation of adenylate cyclase in yeast , 1990, Cell.

[14]  M. Moran,et al.  Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases , 1990, Nature.

[15]  A. Brown,et al.  ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels , 1990, Cell.

[16]  T. Fleming,et al.  PDGF induction of tyrosine phosphorylation of GTPase activating protein , 1989, Nature.