Sirtuin-1 regulation of mammalian metabolism.

[1]  T. Veenstra,et al.  SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism* , 2010, The Journal of Biological Chemistry.

[2]  M. Dietrich,et al.  Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity , 2010, The Journal of Neuroscience.

[3]  David P. Carney,et al.  SIRT1 Activation by Small Molecules , 2010, The Journal of Biological Chemistry.

[4]  Qing Xu,et al.  Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress , 2010, Molecular and Cellular Biology.

[5]  R. Coppari,et al.  SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. , 2010, Cell metabolism.

[6]  P. Puigserver,et al.  Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. , 2010, Genes & development.

[7]  K. Petersen,et al.  Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.

[8]  Jianping Ye,et al.  Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. , 2010, Endocrinology.

[9]  L. Guarente,et al.  Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. , 2010, Trends in pharmacological sciences.

[10]  M. Vinciguerra,et al.  SirT1 in muscle physiology and disease: lessons from mouse models , 2010, Disease Models & Mechanisms.

[11]  M. Nishiyama,et al.  PPARβ/δ regulates the human SIRT1 gene transcription via Sp1 , 2010 .

[12]  G. Shulman,et al.  Diacylglycerol-mediated insulin resistance , 2010, Nature Medicine.

[13]  J. Olefsky,et al.  SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. , 2010, American journal of physiology. Endocrinology and metabolism.

[14]  G. Gores,et al.  Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. , 2010, The Journal of clinical investigation.

[15]  Venkataraman Thanabal,et al.  SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦ , 2010, The Journal of Biological Chemistry.

[16]  C. Vaslet,et al.  Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System , 2009, PloS one.

[17]  G. Shulman,et al.  Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. , 2009, Cell metabolism.

[18]  Shu-Chen Lu,et al.  Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity , 2009, Chemical biology & drug design.

[19]  M. McBurney,et al.  The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. , 2009, The Journal of clinical investigation.

[20]  Nathan R. Qi,et al.  The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice , 2009, Cell.

[21]  C. Deng,et al.  Recent progress in the biology and physiology of sirtuins , 2009, Nature.

[22]  M. Gillum,et al.  SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats , 2009, Proceedings of the National Academy of Sciences.

[23]  Qing Xu,et al.  Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. , 2009, Cell metabolism.

[24]  M. Dietrich,et al.  STAT3 inhibition of gluconeogenesis is downregulated by SirT1 , 2009, Nature Cell Biology.

[25]  Howard Y. Chang,et al.  SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span , 2009, Cell.

[26]  J. Olefsky,et al.  SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes , 2008, Molecular and Cellular Biology.

[27]  Tamas L. Horvath,et al.  N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake , 2008, Cell.

[28]  J. Auwerx,et al.  Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. , 2008, Cell metabolism.

[29]  Alexander S Banks,et al.  SirT1 gain of function increases energy efficiency and prevents diabetes in mice. , 2008, Cell metabolism.

[30]  W. Staines,et al.  sirt1-null mice develop an autoimmune-like condition. , 2008, Experimental cell research.

[31]  A. Bookout,et al.  Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability , 2008, The Journal of Neuroscience.

[32]  P. Elliott,et al.  Sirtuins — novel therapeutic targets to treat age-associated diseases , 2008, Nature Reviews Drug Discovery.

[33]  J. Yates,et al.  A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange , 2008, Nature.

[34]  Fan Lan,et al.  SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase* , 2008, Journal of Biological Chemistry.

[35]  P. Pfluger,et al.  Sirt1 protects against high-fat diet-induced metabolic damage , 2008, Proceedings of the National Academy of Sciences.

[36]  F. Alt,et al.  Tissue-specific regulation of SIRT1 by calorie restriction. , 2008, Genes & development.

[37]  B. Richelsen,et al.  Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women , 2008, International Journal of Obesity.

[38]  M. Czech,et al.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes , 2008, Nature Reviews Molecular Cell Biology.

[39]  M. McBurney,et al.  SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice , 2008, PloS one.

[40]  Junjie Chen,et al.  DBC1 is a negative regulator of SIRT1 , 2008, Nature.

[41]  J. Qin,et al.  Negative regulation of the deacetylase SIRT1 by DBC1 , 2008, Nature.

[42]  Amy V. Lynch,et al.  Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.

[43]  S. Um,et al.  Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. , 2007, Molecular cell.

[44]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[45]  P. Puigserver,et al.  Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1 , 2007, Proceedings of the National Academy of Sciences.

[46]  K. Petersen,et al.  Disordered lipid metabolism and the pathogenesis of insulin resistance. , 2007, Physiological reviews.

[47]  J. Shao,et al.  SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex* , 2006, Journal of Biological Chemistry.

[48]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[49]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[50]  Madeleine Lemieux,et al.  Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells , 2005, PLoS biology.

[51]  M. Montminy,et al.  The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.

[52]  J. Speakman,et al.  Contribution of different mechanisms to compensation for energy restriction in the mouse. , 2005, Obesity research.

[53]  M. Permutt,et al.  Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. , 2005, Cell metabolism.

[54]  Brian C. Smith,et al.  Mechanism of Human SIRT1 Activation by Resveratrol* , 2005, Journal of Biological Chemistry.

[55]  L. Guarente,et al.  Calorie Restriction— the SIR2 Connection , 2005, Cell.

[56]  B. Rogina,et al.  Sir2 mediates longevity in the fly through a pathway related to calorie restriction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[57]  D. Reinberg,et al.  Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. , 2004, Molecular cell.

[58]  Matt Kaeberlein,et al.  Sir2-Independent Life Span Extension by Calorie Restriction in Yeast , 2004, PLoS biology.

[59]  M. Mayo,et al.  Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.

[60]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[61]  Phuong Chung,et al.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.

[62]  Bruce M. Spiegelman,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.

[63]  Blanka Rogina,et al.  Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction , 2002, Science.

[64]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[65]  G. Fink,et al.  Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration , 2002, Nature.

[66]  J. Dhahbi,et al.  Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[67]  P. Schmid-Hempel,et al.  Survival for immunity: the price of immune system activation for bumblebee workers. , 2000, Science.

[68]  P. Defossez,et al.  Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. , 2000, Science.

[69]  T Hashimoto,et al.  Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting* , 2000, The Journal of Biological Chemistry.

[70]  L. Guarente,et al.  Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.

[71]  G. Shulman,et al.  On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .

[72]  M. McVey,et al.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.

[73]  M. Nishiyama,et al.  PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. , 2010, Endocrine journal.

[74]  S. Voelter-Mahlknecht,et al.  Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse. , 2009, International journal of molecular medicine.

[75]  S. Voelter-Mahlknecht,et al.  Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1. , 2006, International journal of molecular medicine.

[76]  Steven P Gygi,et al.  Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. , 2005, Nature.

[77]  Jerry Donovan,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.

[78]  R. Huber,et al.  Transcriptional silencing and longevity protein Sir 2 is an NAD-dependent histone deacetylase , 2022 .