Sirtuin-1 regulation of mammalian metabolism.
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[1] T. Veenstra,et al. SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism* , 2010, The Journal of Biological Chemistry.
[2] M. Dietrich,et al. Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity , 2010, The Journal of Neuroscience.
[3] David P. Carney,et al. SIRT1 Activation by Small Molecules , 2010, The Journal of Biological Chemistry.
[4] Qing Xu,et al. Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress , 2010, Molecular and Cellular Biology.
[5] R. Coppari,et al. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. , 2010, Cell metabolism.
[6] P. Puigserver,et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. , 2010, Genes & development.
[7] K. Petersen,et al. Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.
[8] Jianping Ye,et al. Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. , 2010, Endocrinology.
[9] L. Guarente,et al. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. , 2010, Trends in pharmacological sciences.
[10] M. Vinciguerra,et al. SirT1 in muscle physiology and disease: lessons from mouse models , 2010, Disease Models & Mechanisms.
[11] M. Nishiyama,et al. PPARβ/δ regulates the human SIRT1 gene transcription via Sp1 , 2010 .
[12] G. Shulman,et al. Diacylglycerol-mediated insulin resistance , 2010, Nature Medicine.
[13] J. Olefsky,et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. , 2010, American journal of physiology. Endocrinology and metabolism.
[14] G. Gores,et al. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. , 2010, The Journal of clinical investigation.
[15] Venkataraman Thanabal,et al. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦ , 2010, The Journal of Biological Chemistry.
[16] C. Vaslet,et al. Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System , 2009, PloS one.
[17] G. Shulman,et al. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. , 2009, Cell metabolism.
[18] Shu-Chen Lu,et al. Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity , 2009, Chemical biology & drug design.
[19] M. McBurney,et al. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. , 2009, The Journal of clinical investigation.
[20] Nathan R. Qi,et al. The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice , 2009, Cell.
[21] C. Deng,et al. Recent progress in the biology and physiology of sirtuins , 2009, Nature.
[22] M. Gillum,et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats , 2009, Proceedings of the National Academy of Sciences.
[23] Qing Xu,et al. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. , 2009, Cell metabolism.
[24] M. Dietrich,et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1 , 2009, Nature Cell Biology.
[25] Howard Y. Chang,et al. SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span , 2009, Cell.
[26] J. Olefsky,et al. SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes , 2008, Molecular and Cellular Biology.
[27] Tamas L. Horvath,et al. N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake , 2008, Cell.
[28] J. Auwerx,et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. , 2008, Cell metabolism.
[29] Alexander S Banks,et al. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. , 2008, Cell metabolism.
[30] W. Staines,et al. sirt1-null mice develop an autoimmune-like condition. , 2008, Experimental cell research.
[31] A. Bookout,et al. Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability , 2008, The Journal of Neuroscience.
[32] P. Elliott,et al. Sirtuins — novel therapeutic targets to treat age-associated diseases , 2008, Nature Reviews Drug Discovery.
[33] J. Yates,et al. A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange , 2008, Nature.
[34] Fan Lan,et al. SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase* , 2008, Journal of Biological Chemistry.
[35] P. Pfluger,et al. Sirt1 protects against high-fat diet-induced metabolic damage , 2008, Proceedings of the National Academy of Sciences.
[36] F. Alt,et al. Tissue-specific regulation of SIRT1 by calorie restriction. , 2008, Genes & development.
[37] B. Richelsen,et al. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women , 2008, International Journal of Obesity.
[38] M. Czech,et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes , 2008, Nature Reviews Molecular Cell Biology.
[39] M. McBurney,et al. SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice , 2008, PloS one.
[40] Junjie Chen,et al. DBC1 is a negative regulator of SIRT1 , 2008, Nature.
[41] J. Qin,et al. Negative regulation of the deacetylase SIRT1 by DBC1 , 2008, Nature.
[42] Amy V. Lynch,et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.
[43] S. Um,et al. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. , 2007, Molecular cell.
[44] G. Shulman,et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.
[45] P. Puigserver,et al. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1 , 2007, Proceedings of the National Academy of Sciences.
[46] K. Petersen,et al. Disordered lipid metabolism and the pathogenesis of insulin resistance. , 2007, Physiological reviews.
[47] J. Shao,et al. SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex* , 2006, Journal of Biological Chemistry.
[48] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[49] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[50] Madeleine Lemieux,et al. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells , 2005, PLoS biology.
[51] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[52] J. Speakman,et al. Contribution of different mechanisms to compensation for energy restriction in the mouse. , 2005, Obesity research.
[53] M. Permutt,et al. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. , 2005, Cell metabolism.
[54] Brian C. Smith,et al. Mechanism of Human SIRT1 Activation by Resveratrol* , 2005, Journal of Biological Chemistry.
[55] L. Guarente,et al. Calorie Restriction— the SIR2 Connection , 2005, Cell.
[56] B. Rogina,et al. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[57] D. Reinberg,et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. , 2004, Molecular cell.
[58] Matt Kaeberlein,et al. Sir2-Independent Life Span Extension by Calorie Restriction in Yeast , 2004, PLoS biology.
[59] M. Mayo,et al. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.
[60] M. Desai,et al. Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.
[61] Phuong Chung,et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.
[62] Bruce M. Spiegelman,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.
[63] Blanka Rogina,et al. Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction , 2002, Science.
[64] S. Uchida,et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.
[65] G. Fink,et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration , 2002, Nature.
[66] J. Dhahbi,et al. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[67] P. Schmid-Hempel,et al. Survival for immunity: the price of immune system activation for bumblebee workers. , 2000, Science.
[68] P. Defossez,et al. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. , 2000, Science.
[69] T Hashimoto,et al. Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting* , 2000, The Journal of Biological Chemistry.
[70] L. Guarente,et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.
[71] G. Shulman,et al. On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .
[72] M. McVey,et al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.
[73] M. Nishiyama,et al. PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. , 2010, Endocrine journal.
[74] S. Voelter-Mahlknecht,et al. Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse. , 2009, International journal of molecular medicine.
[75] S. Voelter-Mahlknecht,et al. Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1. , 2006, International journal of molecular medicine.
[76] Steven P Gygi,et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. , 2005, Nature.
[77] Jerry Donovan,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.
[78] R. Huber,et al. Transcriptional silencing and longevity protein Sir 2 is an NAD-dependent histone deacetylase , 2022 .