CD4+ T cells specific for factor VIII as a target for specific suppression of inhibitor production.
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N. Key | H. Wu | M. Reding | M. Krampf | D. Okita | B. Diethelm-Okita | B. Conti-Fine | B. Diethelm‐Okita
[1] D. Okita,et al. Universal epitopes for human CD4+ cells on tetanus and diphtheria toxins. , 2000, The Journal of infectious diseases.
[2] M. Grusby,et al. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. , 1999, Journal of immunology.
[3] P. Karachunski,et al. Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4+ epitope sequences of the acetylcholine receptor , 1999, Journal of Neuroimmunology.
[4] R. Garman,et al. Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis , 1999, Journal of Neuroimmunology.
[5] K. Garcia,et al. Structural basis of T cell recognition. , 1999, Annual review of immunology.
[6] E. Getzoff,et al. Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. , 1998, Blood cells, molecules & diseases.
[7] R. Stevens,et al. Crystal structure of botulinum neurotoxin type A and implications for toxicity , 1998, Nature Structural Biology.
[8] K. Murphy,et al. Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells , 1998, The Journal of Immunology.
[9] S. Sriram,et al. TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. , 1998, Journal of immunology.
[10] C. Kessler,et al. Factor VIII immunogenicity , 1998, Haemophilia : the official journal of the World Federation of Hemophilia.
[11] M. Shima,et al. Some human inhibitor antibodies interfere with factor VIII binding to factor IX. , 1998, Blood.
[12] A. Roberts,et al. Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production. , 1998, Journal of immunology.
[13] E. Sercarz,et al. Modulation of the immunogenicity of antigenic determinants by their flanking residues. , 1998, Immunology today.
[14] N. Sarvetnick,et al. TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. , 1998, Immunity.
[15] Anita B. Roberts,et al. REGULATION OF IMMUNE RESPONSES BY TGF-β* , 1998 .
[16] A. O’Garra,et al. Cytokines induce the development of functionally heterogeneous T helper cell subsets. , 1998, Immunity.
[17] P. Karachunski,et al. Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences. , 1997, The Journal of clinical investigation.
[18] P. Lehmann,et al. Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens , 1997, The Journal of experimental medicine.
[19] L. Steinman,et al. CD4+ T-cell subsets in autoimmunity. , 1997, Current opinion in immunology.
[20] W. Weigle,et al. CD4+ T-cell subsets and cytokines involved in peripheral tolerance. , 1997, Immunology today.
[21] S. Landry,et al. Local protein instability predictive of helper T-cell epitopes. , 1997, Immunology today.
[22] S. Swaminathan,et al. Structure of the receptor binding fragment HC of tetanus neurotoxin , 1997, Nature Structural Biology.
[23] J. Saint-Remy,et al. Factor VIII Inhibitors , 1997, Thrombosis and Haemostasis.
[24] S. Romagnani,et al. The Th1/Th2 paradigm. , 1997, Immunology today.
[25] P. Salgame,et al. Differential ability of T cell subsets to undergo activation-induced cell death. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[26] D. Green,et al. Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis , 1997, The Journal of experimental medicine.
[27] G. Card,et al. A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. , 1997, Blood.
[28] D. Okita,et al. Epitope repertoire of human CD4+ T cells on tetanus toxin: identification of immunodominant sequence segments. , 1997, The Journal of infectious diseases.
[29] C. Watts,et al. Capture and processing of exogenous antigens for presentation on MHC molecules. , 1997, Annual review of immunology.
[30] M. Bellone,et al. Myasthenia Gravis: The Immunobiology of an Autoimmune Disease , 1996 .
[31] S. Hauser,et al. Late Complications of Immune Deviation Therapy in a Nonhuman Primate , 1996, Science.
[32] Kenneth M. Murphy,et al. Functional diversity of helper T lymphocytes , 1996, Nature.
[33] A. Lucas,et al. T Lymphocyte Proliferative Responses Induced by Recombinant Factor VIII in Hemophilia A Patients with Inhibitors , 1996, Thrombosis and Haemostasis.
[34] R. Schwartz,et al. Models of T Cell Anergy: Is There a Common Molecular Mechanism? , 1996 .
[35] C. Kessler,et al. 9 Acquired inhibitors , 1996 .
[36] J. Bluestone,et al. CD28/B7 system of T cell costimulation. , 1996, Annual review of immunology.
[37] C. Escuriola-Ettingshausen,et al. Epidemiology of Inhibitors in Haemophilia A , 1996, Vox sanguinis.
[38] C. Janeway,et al. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[39] G. Cohen,et al. Interactions of protein antigens with antibodies. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[40] B M Conti-Fine,et al. Antibodies as tools to study the structure of membrane proteins: the case of the nicotinic acetylcholine receptor. , 1996, Annual review of biophysics and biomolecular structure.
[41] J. Kraehenbuhl,et al. Antigen sampling across epithelial barriers and induction of mucosal immune responses. , 1996, Annual review of immunology.
[42] D. Mccormick,et al. Epitopes for human CD4+ cells on diphtheria toxin: Structural features of sequence segments forming epitopes recognized by most subjects , 1995, European journal of immunology.
[43] M. Shima,et al. Common inhibitory effects of human anti‐C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor , 1995, British journal of haematology.
[44] J. Morris,et al. TSH receptor sequences recognized by CD4+ T cells in Graves' disease patients and healthy controls. , 1995, Journal of autoimmunity.
[45] G. E. Gilbert,et al. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site. , 1995, Blood.
[46] H. Weiner,et al. Peripheral deletion of antigen-reactive T cells in oral tolerance , 1995, Nature.
[47] T. Medsger,et al. T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors. , 1995, The Journal of clinical investigation.
[48] J. Healey,et al. Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII (*) , 1995, The Journal of Biological Chemistry.
[49] Warren Strober,et al. Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome , 1995, Cell.
[50] F. Rieux-Laucat,et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. , 1995, Science.
[51] G. Nossal. Choices following antigen entry: antibody formation or immunologic tolerance? , 1995, Annual review of immunology.
[52] D. Madden. The three-dimensional structure of peptide-MHC complexes. , 1995, Annual review of immunology.
[53] L. Hoyer. The incidence of factor VIII inhibitors in patients with severe hemophilia A. , 1995, Advances in experimental medicine and biology.
[54] L. Aledort,et al. Inhibitors to Coagulation Factors , 1995, Advances in Experimental Medicine and Biology.
[55] L. Aledort. Inhibitors in hemophilia patients: Current status and management , 1994, American journal of hematology.
[56] J. Saint-Remy,et al. Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies. , 1994, The Journal of clinical investigation.
[57] H. Weiner,et al. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[58] C. Elson,et al. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. , 1994, Journal of immunology.
[59] L. Hoyer,et al. Factor VIII inhibitors: structure and function in autoantibody and hemophilia A patients. , 1994, Seminars in hematology.
[60] Don C. Wiley,et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide , 1994, Nature.
[61] L. Moiola,et al. Epitopes on the beta subunit of human muscle acetylcholine receptor recognized by CD4+ cells of myasthenia gravis patients and healthy subjects. , 1994, The Journal of clinical investigation.
[62] J. Goverman,et al. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. , 1994, Science.
[63] J. Banchereau,et al. Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3 , 1994, The Journal of experimental medicine.
[64] V. Engelhard,et al. Structure of peptides associated with class I and class II MHC molecules. , 1994, Annual review of immunology.
[65] P. Cresswell,et al. Assembly, transport, and function of MHC class II molecules. , 1994, Annual review of immunology.
[66] H. Weiner,et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. , 1994, Annual review of immunology.
[67] M. Jenkins,et al. The role of anergy in peripheral T cell unresponsiveness. , 1994, Life sciences.
[68] P. Matzinger. Tolerance, danger, and the extended family. , 1994, Annual review of immunology.
[69] S J Rodda,et al. Mapping the major human T helper epitopes of tetanus toxin. The emerging picture. , 1993, Journal of immunology.
[70] C. Caldwell,et al. Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals. , 1993, Journal of immunology.
[71] L. Donoso,et al. Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols. , 1993, Journal of immunology.
[72] K. Tadokoro,et al. Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors. , 1993, Journal of immunology.
[73] J. Arnout,et al. Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction. , 1993, Blood.
[74] R M Horton,et al. Myasthenia gravis: recognition of a human autoantigen at the molecular level. , 1993, Immunology today.
[75] William Arbuthnot Sir Lane,et al. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles , 1993, The Journal of experimental medicine.
[76] G. Macpherson,et al. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo , 1993, The Journal of experimental medicine.
[77] J. Goedert,et al. Loss of high‐responder inhibitors in patients with severe hemophilia A and human immunodeficiency virus type 1 infection: A report from the multi‐center hemophilia cohort study , 1993, American journal of hematology.
[78] R. Germain,et al. The biochemistry and cell biology of antigen processing and presentation. , 1993, Annual review of immunology.
[79] A Sette,et al. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. , 1992, Science.
[80] Katherine A. Kantardjieff,et al. The crystal structure of diphtheria toxin , 1992, Nature.
[81] M. Kazatchkine,et al. Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[82] K. Rajewsky,et al. Generation and analysis of interleukin-4 deficient mice. , 1991, Science.
[83] A. Rudensky,et al. Sequence analysis of peptides bound to MHC class II molecules , 1991, Nature.
[84] Joshua R. Smith,et al. T cell sensitization to factor VIII in haemophilia A? , 1991, British journal of haematology.
[85] A. Abbas,et al. Cellular and Molecular Immunology , 1991 .
[86] L. Kappos,et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[87] H. Weiner,et al. T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis , 1990, Nature.
[88] P. Ho,et al. Identification of two promiscuous T cell epitopes from tetanus toxin , 1990, European journal of immunology.
[89] B. Dahlbäck,et al. Noncoagulation inhibitory factor VIII antibodies after induction of tolerance to factor VIII in hemophilia A patients. , 1990, Blood.
[90] Antonio Lanzavecchia,et al. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells , 1989, European journal of immunology.
[91] Antonio Lanzavecchia,et al. Antigen-specific interaction between T and B cells , 1985, Nature.
[92] B. Keyt,et al. Structure of human factor VIII , 1984, Nature.
[93] A. Engel. Myasthenia gravis and myasthenic syndromes , 1984, Annals of neurology.
[94] B. Zweiman,et al. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. , 1983, Cellular immunology.