Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction.

[1]  R. Schweitzer,et al.  Recruitment and maintenance of tendon progenitors by TGFβ signaling are essential for tendon formation , 2009, Development.

[2]  D. Kingsley,et al.  Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation , 2008, BMC Developmental Biology.

[3]  R. Johnson,et al.  HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis , 2007, Development.

[4]  R. Serra,et al.  Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints. , 2007, Developmental biology.

[5]  C. Tabin,et al.  Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons , 2007, Development.

[6]  Harold L. Moses,et al.  TGF-β signaling is essential for joint morphogenesis , 2007, The Journal of cell biology.

[7]  G. Wagner,et al.  Scleraxis and NFATc Regulate the Expression of the Pro-α1(I) Collagen Gene in Tendon Fibroblasts* , 2007, Journal of Biological Chemistry.

[8]  C. Tabin,et al.  Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[9]  Ying Wang,et al.  BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. , 2006, Developmental biology.

[10]  J. Ralphs,et al.  Where tendons and ligaments meet bone: attachment sites (‘entheses’) in relation to exercise and/or mechanical load , 2006, Journal of anatomy.

[11]  J. Massagué,et al.  Smad transcription factors. , 2005, Genes & development.

[12]  Delphine Duprez,et al.  Tendon and ligament: development, repair and disease. , 2005, Birth defects research. Part C, Embryo today : reviews.

[13]  D. Ovchinnikov,et al.  Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  M. Bonnin,et al.  Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation , 2005, Mechanisms of Development.

[15]  T. Braun,et al.  Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development , 2005, Development.

[16]  Wei Liu,et al.  Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. , 2004, Developmental biology.

[17]  H. Moses,et al.  Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. , 2004, Developmental biology.

[18]  D. Kingsley,et al.  BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage , 2004, PLoS biology.

[19]  C. Tabin,et al.  FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression , 2004, Development.

[20]  J. H. Chae,et al.  Transcription factor CP2 is involved in activating mBMP4 in mouse mesenchymal stem cells. , 2004, Molecules and cells.

[21]  R. Schwartz,et al.  Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[23]  H. Kronenberg,et al.  Developmental regulation of the growth plate , 2003, Nature.

[24]  C. Tabin,et al.  A Somitic Compartment of Tendon Progenitors , 2003, Cell.

[25]  J. Ralphs,et al.  The skeletal attachment of tendons--tendon "entheses". , 2002, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[26]  M. Bonnin,et al.  Fgf4 positively regulates scleraxis and tenascin expression in chick limb tendons. , 2002, Developmental biology.

[27]  C. Tabin,et al.  Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer , 2002, Genesis.

[28]  E. Wagner,et al.  Reaching a genetic and molecular understanding of skeletal development. , 2002, Developmental cell.

[29]  C. Tabin,et al.  Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. , 2001, Development.

[30]  T. Volk.  Singling out Drosophila tendon cells: a dialogue between two distinct cell types. , 1999, Trends in genetics : TIG.

[31]  A. Lassar,et al.  Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. , 1999, Genes & development.

[32]  D. Paulin,et al.  A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors. , 1998, Developmental biology.

[33]  G. Kardon,et al.  Muscle and tendon morphogenesis in the avian hind limb. , 1998, Development.

[34]  K. Patel,et al.  Tbx genes and limb identity in chick embryo development. , 1998, Development.

[35]  Y. Liu,et al.  Overexpression of a Single Helix-Loop-Helix-type Transcription Factor, Scleraxis, Enhances Aggrecan Gene Expression in Osteoblastic Osteosarcoma ROS17/2.8 Cells* , 1997, The Journal of Biological Chemistry.

[36]  A A Biewener,et al.  Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse. , 1996, Bone.

[37]  G. Lyons,et al.  Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. , 1995, Development.

[38]  K. Lyons,et al.  A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. , 1994, Biochemical and biophysical research communications.

[39]  C. Tabin,et al.  Sonic hedgehog mediates the polarizing activity of the ZPA , 1993, Cell.

[40]  G. Lyons,et al.  Modulation of contractile protein gene expression in fetal murine crural muscles: Emergence of muscle diversity , 1993, Developmental dynamics : an official publication of the American Association of Anatomists.

[41]  M. Surani,et al.  The Splotch mutation interferes with muscle development in the limbs , 1993, Anatomy and Embryology.

[42]  A. Hosseini,et al.  The effects of paralysis on skeletal development in the chick embryo. , 1992, Comparative biochemistry and physiology. Comparative physiology.

[43]  A. Hosseini,et al.  The effects of paralysis on skeletal development in the chick embryo. I. General effects. , 1991, Journal of anatomy.

[44]  S W Herring,et al.  Paralysis and growth of the musculoskeletal system in the embryonic chick , 1990, Journal of morphology.

[45]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[46]  J. Graham,et al.  Determinants in the morphogenesis of muscle tendon insertions. , 1982 .

[47]  M J McLeod,et al.  Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. , 1980, Teratology.

[48]  A. Reddi,et al.  Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[50]  A. C. Pai.  DEVELOPMENTAL GENETICS OF A LETHAL MUTATION, MUSCULAR DYSGENESIS (MDG), IN THE MOUSE. II. DEVELOPMENTAL ANALYSIS. , 1965, Developmental biology.

[51]  A. C. Pai.  DEVELOPMENTAL GENETICS OF A LETHAL MUTATION, MUSCULAR DYSGENESIS (MDG), IN THE MOUSE. I. GENETIC ANALYSIS AND GROSS MORPHOLOGY. , 1965, Developmental biology.

[52]  M. Dickie.  NEW SPLOTCH ALLELES IN THE MOUSE. , 1964, The Journal of heredity.

[53]  V. Hamburger,et al.  The Primary Development of the Skeleton in Nerveless and Poorly Innervated Limb Transplants of Chick Embryos , 1940, Physiological Zoology.

[54]  Viktor Hamburger,et al.  The development and innervation of transplanted limb primordia of chick embryos , 1939 .

[55]  J. A. Howell.  An experimental study of the effect of stress and strain on bone development , 1917 .

[56]  John C. Koch,et al.  The laws of bone architecture , 1917 .

[57]  K. Lyons,et al.  BMP signaling in the cartilage growth plate. , 2006, Current topics in developmental biology.

[58]  B. Hallgrímsson,et al.  Myf5−/−:MyoD−/− amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis , 2005, Development Genes and Evolution.

[59]  J. Massagué,et al.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.

[60]  H. Moses,et al.  Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. , 2002, Genesis.

[61]  B. Olsen,et al.  Bone development. , 2000, Annual review of cell and developmental biology.

[62]  Philippe Soriano.  Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.

[63]  K. Ogawa,et al.  Deltoid contracture: a radiographic survey of bone and joint abnormalities. , 1999, Journal of shoulder and elbow surgery.

[64]  M. Kieny,et al.  Autonomy of tendon development in the embryonic chick wing. , 1979, Journal of embryology and experimental morphology.

[65]  V. Hamburger.  Morphogenetic and axial self-differentiation of transplanted limb primordia of 2-day chick embryos† , 1938 .