Photoreceptor layer thinning is an early biomarker for age-related macular degeneration: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data.

[1]  T. Elze,et al.  Characteristics of Gln368Ter Myocilin variant and influence of polygenic risk on glaucoma penetrance in the UK Biobank. , 2021, Ophthalmology.

[2]  G. Hageman,et al.  Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10 , 2020, Scientific Reports.

[3]  Hongyu Zhao,et al.  Elevated Blood Pressure Increases Pneumonia Risk: Epidemiological Association and Mendelian Randomization in the UK Biobank , 2020, Med.

[4]  C. Curcio,et al.  Measuring the Contributions of Basal Laminar Deposit and Bruch's Membrane in Age-Related Macular Degeneration , 2020, Investigative ophthalmology & visual science.

[5]  Charles A Reisman,et al.  Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images , 2020, medRxiv.

[6]  Charles A Reisman,et al.  Associations with photoreceptor thickness measures in the UK Biobank , 2019, Scientific Reports.

[7]  Sina Farsiu,et al.  Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration , 2019, PloS one.

[8]  Hongyu Zhao,et al.  Genetic Link Between Arterial Stiffness and Atrial Fibrillation. , 2019, Circulation. Genomic and precision medicine.

[9]  Hongyu Zhao,et al.  Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease. , 2019, Arteriosclerosis, thrombosis, and vascular biology.

[10]  K. Stark,et al.  Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study , 2019, Investigative ophthalmology & visual science.

[11]  Hua Huang,et al.  Genome‐wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort , 2018, Human molecular genetics.

[12]  K. Nishida,et al.  High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models. , 2018, The American journal of pathology.

[13]  P. Donnelly,et al.  The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.

[14]  T. Ge,et al.  Polygenic prediction via Bayesian regression and continuous shrinkage priors , 2018, bioRxiv.

[15]  Bianca S. Gerendas,et al.  Prediction of Individual Disease Conversion in Early AMD Using Artificial Intelligence. , 2018, Investigative ophthalmology & visual science.

[16]  S. Sadda,et al.  Postreceptor Neuronal Loss in Intermediate Age-related Macular Degeneration. , 2017, American journal of ophthalmology.

[17]  W. Freeman,et al.  QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION , 2017, Retina.

[18]  S. Zekavat,et al.  An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD[S] , 2017, Journal of Lipid Research.

[19]  Mark J J P van Grinsven,et al.  Automated Staging of Age-Related Macular Degeneration Using Optical Coherence Tomography. , 2017, Investigative ophthalmology & visual science.

[20]  Kinpui Chan,et al.  Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies , 2016, PloS one.

[21]  Yara T. E. Lechanteur,et al.  Nature Genetics Advance Online Publication , 2022 .

[22]  M. V. Cicinelli,et al.  Macular ganglion cell complex and retinal nerve fiber layer comparison in different stages of age-related macular degeneration. , 2015, American journal of ophthalmology.

[23]  E. Lee,et al.  Ganglion Cell-Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Thicknesses in Age-Related Macular Degeneration. , 2015, Investigative ophthalmology & visual science.

[24]  P. Mitchell,et al.  Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration , 2013, European Journal of Human Genetics.

[25]  Qi Yang,et al.  Automated layer segmentation of macular OCT images using dual-scale gradient information. , 2010, Optics express.

[26]  Christine A. Curcio,et al.  Abundant Lipid and Protein Components of Drusen , 2010, PloS one.

[27]  Johanna M Seddon,et al.  Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. , 2009, Investigative ophthalmology & visual science.

[28]  M. Halushka,et al.  Tissue Inhibitor of Matrix Metalloproteinase-3 Levels in the Extracellular Matrix of Lung, Kidney, and Eye Increase With Age , 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[29]  T. Salt,et al.  Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction , 2007, Proceedings of the National Academy of Sciences.

[30]  M. Killingsworth,et al.  Relationship of Basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration. , 2007, Investigative ophthalmology & visual science.

[31]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[32]  Johanna M Seddon,et al.  The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. , 2005, Archives of ophthalmology.

[33]  C. Curcio Photoreceptor topography in ageing and age-related maculopathy , 2001, Eye.

[34]  M. Kamei,et al.  TIMP-3 in Bruch's membrane: changes during aging and in age-related macular degeneration. , 1999, Investigative ophthalmology & visual science.

[35]  M. Killingsworth,et al.  Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study , 1999, The British journal of ophthalmology.

[36]  C. Curcio,et al.  Photoreceptor loss in age-related macular degeneration. , 1996, Investigative ophthalmology & visual science.

[37]  R. Pruett,et al.  Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy , 1994, Nature Genetics.

[38]  J. Marshall,et al.  Convolution in human rods: an ageing process. , 1979, The British journal of ophthalmology.

[39]  R. Armstrong,et al.  Overview of Risk Factors for Age-Related Macular Degeneration (AMD). , 2015, Journal of stem cells.

[40]  Ye Wang,et al.  Age-related maculopathy susceptibility 2 participates in the phagocytosis functions of the retinal pigment epithelium. , 2012, International journal of ophthalmology.