Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging

[1]  Adrian V. Lee,et al.  Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. , 2008, Developmental biology.

[2]  L. Donehower,et al.  Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity , 2007, Mechanisms of Ageing and Development.

[3]  A. Levine,et al.  Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations , 2007, Proceedings of the National Academy of Sciences.

[4]  J. Campisi,et al.  Two faces of p53: aging and tumor suppression , 2007, Nucleic acids research.

[5]  Ronald A. DePinho,et al.  How stem cells age and why this makes us grow old , 2007, Nature Reviews Molecular Cell Biology.

[6]  M. Blasco,et al.  Cancer and ageing: convergent and divergent mechanisms , 2007, Nature Reviews Molecular Cell Biology.

[7]  Chad A Shaw,et al.  Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation , 2007, PLoS biology.

[8]  L. Donehower,et al.  The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. , 2007, Blood.

[9]  M. Turker,et al.  Age‐related accumulation of autosomal mutations in solid tissues of the mouse is gender and cell type specific , 2007, Aging cell.

[10]  J. Hoeijmakers,et al.  Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome , 2006, PLoS biology.

[11]  J. Hoeijmakers,et al.  A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis , 2006, Nature.

[12]  Jiri Bartek,et al.  p16INK4A is a robust in vivo biomarker of cellular aging in human skin , 2006, Aging cell.

[13]  K. Ligon,et al.  p16INK4a induces an age-dependent decline in islet regenerative potential , 2006, Nature.

[14]  R. DePinho,et al.  Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a , 2006, Nature.

[15]  S. Morrison,et al.  Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing , 2006, Nature.

[16]  S. Sommer,et al.  Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype. , 2006, Carcinogenesis.

[17]  T. Prolla,et al.  Mitochondrial DNA mutations and apoptosis in mammalian aging. , 2006, Cancer research.

[18]  P. Kirkpatrick,et al.  Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress , 2006, Circulation research.

[19]  T. Rando.  Stem cells, ageing and the quest for immortality , 2006, Nature.

[20]  J. Vijg,et al.  Maintaining genetic integrity in aging: a zero sum game. , 2006, Antioxidants & redox signaling.

[21]  S. Venkatachalam.  Aging, p53 and the ‘24 gene mutant’: getting it right A reply to Vijg and Hasty , 2005, Aging cell.

[22]  P. Hasty,et al.  Aging and p53: getting it straight A commentary on a recent paper by Gentry and Venkatachalam , 2005, Aging cell.

[23]  W. Deppert,et al.  Transcription-independent pro-apoptotic functions of p53. , 2005, Current opinion in cell biology.

[24]  S. Helfand,et al.  Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span , 2005, Current Biology.

[25]  Ignacio Varela,et al.  Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation , 2005, Nature.

[26]  J. Shay,et al.  BRAFE600-associated senescence-like cell cycle arrest of human naevi , 2005, Nature.

[27]  S. Venkatachalam,et al.  Complicating the role of p53 in aging , 2005, Aging cell.

[28]  Bernd W. Brandt,et al.  Variation in the human TP53 gene affects old age survival and cancer mortality1 , 2005, Experimental Gerontology.

[29]  J. Campisi.  Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors , 2005, Cell.

[30]  T. Kirkwood,et al.  Understanding the Odd Science of Aging , 2005, Cell.

[31]  P. Hasty.  The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice , 2005, Mechanisms of Ageing and Development.

[32]  L. Donehower,et al.  p53 and Mouse Aging Models , 2005 .

[33]  S. Lowe,et al.  Intrinsic tumour suppression , 2004, Nature.

[34]  N. Sharpless,et al.  Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.

[35]  K. Mohammad,et al.  Modulation of mammalian life span by the short isoform of p53. , 2004, Genes & development.

[36]  S. Sommer,et al.  Spontaneous mutation in Big Blue® mice from fetus to old age: Tissue‐specific time courses of mutation frequency but similar mutation types , 2004, Environmental and molecular mutagenesis.

[37]  Sam W. Lee,et al.  Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions , 2003, Molecular and Cellular Biology.

[38]  Yingpei Zhang,et al.  Caspases, apoptosis and aging , 2003, Ageing Research Reviews.

[39]  Judith Campisi,et al.  Cancer and ageing: rival demons? , 2003, Nature Reviews Cancer.

[40]  J. Hoeijmakers,et al.  Aging and Genome Maintenance: Lessons from the Mouse? , 2003, Science.

[41]  C. Deng,et al.  Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. , 2003, Genes & development.

[42]  Martin Holzenberger,et al.  IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.

[43]  P. Klatt,et al.  'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally , 2002, The EMBO journal.

[44]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[45]  L. Donehower.  Does p53 affect organismal aging? , 2002, Journal of cellular physiology.

[46]  Y. Suh.  Cell signaling in aging and apoptosis , 2002, Mechanisms of Ageing and Development.

[47]  J. Hoeijmakers,et al.  Premature Aging in Mice Deficient in DNA Repair and Transcription , 2002, Science.

[48]  D. Dunson,et al.  Mutational fingerprints of aging. , 2002, Nucleic acids research.

[49]  Stephen N. Jones,et al.  p53 mutant mice that display early ageing-associated phenotypes , 2002, Nature.

[50]  S. Shack,et al.  Loss in oxidative stress tolerance with aging linked to reduced extracellular signal‐regulated kinase and Akt kinase activities , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[51]  V. Paradis,et al.  Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. , 2001, Human pathology.

[52]  D. Kurz,et al.  Cellular Senescence After Single and Repeated Balloon Catheter Denudations of Rabbit Carotid Arteries , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[53]  George C. Williams,et al.  PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE , 1957, Science of Aging Knowledge Environment.

[54]  Steven N. Austad,et al.  Why do we age? , 2000, Nature.

[55]  J Vijg,et al.  Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Benson,et al.  Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. , 2000, Urology.

[57]  H. Vogel,et al.  Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53 , 2000, Molecular and Cellular Biology.

[58]  Y. Higami,et al.  Apoptosis in the aging process , 2000, Cell and Tissue Research.

[59]  G. R. Stuart,et al.  Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice. , 2000, Genetics.

[60]  Y. Hosoi,et al.  Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse. , 2000, Mutation research.

[61]  Pier Paolo Pandolfi,et al.  The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.

[62]  H. Vogel,et al.  Deletion of Ku86 causes early onset of senescence in mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[63]  Lynda Chin,et al.  p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis , 1999, Cell.

[64]  Sandy Chang,et al.  Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice , 1999, Cell.

[65]  W. Horton,et al.  Chondrocyte apoptosis increases with age in the articular cartilage of adult animals , 1998, The Anatomical record.

[66]  A. Balmain,et al.  The p53 response to ionising radiation in adult and developing murine tissues. , 1996, Oncogene.

[67]  G. Hannon,et al.  Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[68]  J. Haavik,et al.  p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. , 1995, Oncogene.

[69]  T. Ide,et al.  Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. , 1995, Oncogene.

[70]  L. Donehower,et al.  Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice , 1993, Nature Genetics.

[71]  L. Donehower,et al.  In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. , 1993, Oncogene.

[72]  L. Donehower,et al.  Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.

[73]  Edward L. Schneider,et al.  Handbook of the Biology of Aging , 1990 .