It is crucial to explore a suitable landslide susceptibility model with an excellent prediction capability for rapid evaluation and disaster relief in seismic regions with different lithological features. In this study, we selected two typical seismic events, the Jiuzhaigou and Minxian earthquakes, which occurred in the Alpine karst and loess regions, respectively. Eight influencing factors and five models were chosen to calculate the susceptibility of landslide, including the information (I) model, certainty factor (CF) model, logistic regression (LR) model, I + LR coupling model, and CF + LR coupling model. Then, the accuracy and the landslide susceptibility distribution of these models were assessed by the area under curve (AUC) and distribution criteria. Finally, the model with high accuracy and good applicability for the rock landslide or loess landslide regions was optimized. Our results showed that the accuracy of the coupling model is higher than that of the single models. Except for the LR model, the landslide susceptibility distribution for the above-mentioned models is consistent with universal cognition. The coupling models are generally better than their single models. Among them, the I + LR model can obtain the best comprehensive results for assessing the distribution and accuracy of both rock and loess landslide susceptibility, which is helpful for disaster relief and policy-making, and it can also provide useful scientific data for post-seismic reconstruction and restoration.