A functional magnetic resonance imaging study of cortical regions associated with motor task execution and motor ideation in humans

Although motor performance may be enhanced through mental practice, the neurophysiological substrate of mental stimulation (ideation) of a motor task is not well established. We used blood oxygen level‐dependent contrast echo planar imaging at 1.5 T to identify regions of increased neural activity during the performance and ideation of a motor task. Five subjects performed a sequential finger‐to‐thumb opposition task and also imagined themselves performing the task in the absence of actual muscle movement. In all subjects, the left primary sensorimotor cortex showed more activation with actual movement than with motor ideation, but two subjects had significant activation with motor ideation. The left premotor area showed comparable activation with both actual and imagined performance in three subjects. These findings support the involvement of the primary motor area as well as the premotor area in motor ideation. © 1995 Wiley‐Liss, Inc.

[1]  M. Jeannerod.  The representing brain: Neural correlates of motor intention and imagery , 1994, Behavioral and Brain Sciences.

[2]  M. Mintun,et al.  Nonoxidative glucose consumption during focal physiologic neural activity. , 1988, Science.

[3]  D. Ingvar,et al.  Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance , 1977, Annals of neurology.

[4]  J. Binder,et al.  Functional magnetic resonance imaging of complex human movements , 1993, Neurology.

[5]  P E Roland,et al.  Does mental activity change the oxidative metabolism of the brain? , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[6]  M. Dimitrijevic,et al.  Characteristics of spinal cord-evoked responses in man. , 1980, Applied neurophysiology.

[7]  R. Desimone,et al.  Behavioral neurophysiology: insights into seeing and grasping. , 1988, Science.

[8]  Scott T. Grafton,et al.  Parceling of mesial frontal motor areas during ideation and movement using functional magnetic resonance imaging at 1.5 tesla , 1994, Annals of neurology.

[9]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P E Roland,et al.  Localization of cortical areas activated by thinking. , 1985, Journal of neurophysiology.

[11]  D. Landers,et al.  The effects of mental practice on motor skill learning and performance: A meta-analysis. , 1983 .

[12]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[13]  J. Allman,et al.  Mapping human visual cortex with positron emission tomography , 1986, Nature.

[14]  Ravi S. Menon,et al.  Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. , 1993, Biophysical journal.

[15]  Robert Kohn,et al.  Efficient estimation and prediction in time series regression models , 1985 .

[16]  Leslie G. Ungerleider,et al.  Dissociation of object and spatial visual processing pathways in human extrastriate cortex. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[17]  D. Pandya,et al.  Cortico-cortical connections in the rhesus monkey. , 1969, Brain research.

[18]  P. Roland,et al.  Supplementary motor area and other cortical areas in organization of voluntary movements in man. , 1980, Journal of neurophysiology.

[19]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[20]  Karl J. Friston,et al.  Analysis of functional MRI time‐series , 1994, Human Brain Mapping.

[21]  E C Wong,et al.  Processing strategies for time‐course data sets in functional mri of the human brain , 1993, Magnetic resonance in medicine.

[22]  J. Decety,et al.  Brain structures participating in mental simulation of motor behavior: a neuropsychological interpretation. , 1990, Acta psychologica.

[23]  J. Mazziotta,et al.  Mapping motor representations with positron emission tomography , 1994, Nature.

[24]  D Le Bihan,et al.  Activation of human primary visual cortex during visual recall: a magnetic resonance imaging study. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  P. Appel.  Performance enhancement in physical medicine and rehabilitation. , 1992, The American journal of clinical hypnosis.

[26]  D Le Bihan,et al.  Magnetic Resonance Imaging Functional Activation of Left Frontal Cortex During Covert Word Production , 1994, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[27]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Gandevia.  Roles for perceived voluntary motor commands in motor control , 1987, Trends in Neurosciences.