Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
暂无分享,去创建一个
Tomohiko Maehama | Yigong Shi | P. Pandolfi | J. Dixon | Yigong Shi | Jie-Oh Lee | N. Pavletich | T. Maehama | M. Georgescu | Haijuan Yang | Jack E Dixon | Jie-Oh Lee | Haijuan Yang | Maria-Magdalena Georgescu | Antonio Di Cristofano | Pier Pandolfi | Nikola P Pavletich | A. Cristofano
[1] Roger L. Williams,et al. A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1. , 1997, Biochemistry.
[2] W. K. Alfred Yung,et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers , 1997, Nature Genetics.
[3] Roger L. Williams,et al. Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically* , 1998, The Journal of Biological Chemistry.
[4] Kenneth M. Yamada,et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. , 1998, Science.
[5] W. Cho,et al. A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2 , 1999, The Journal of Biological Chemistry.
[6] José Luis de la Pompa,et al. Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN , 1998, Cell.
[7] Roger L. Williams,et al. Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ , 1996, Nature.
[8] A. M. Riley,et al. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. , 1999, Structure.
[9] R. Jahn,et al. Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain. , 1994, The Journal of biological chemistry.
[10] L. Dekker,et al. Crystal structure of the C2 domain from protein kinase C-delta. , 1998, Structure.
[11] J. Dixon,et al. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. , 1999, Trends in cell biology.
[12] S. Sprang,et al. Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+. , 1998, Structure.
[13] Jack E. Dixon,et al. Crystal Structure of the Dual Specificity Protein Phosphatase VHR , 1996, Science.
[14] M. Wigler,et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[15] D T Jones,et al. Protein fold recognition by sequence threading: tools and assessment techniques , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[16] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[17] W. Cavenee,et al. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[18] Tomohiko Maehama,et al. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.
[19] T. Mak,et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice , 1998, Current Biology.
[20] E. Fauman,et al. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate , 1994, Nature.
[21] T. Südhof,et al. A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. , 1993, The Journal of biological chemistry.
[22] W. Wooster,et al. Crystal structure of , 2005 .
[23] D. Barford,et al. Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. , 1995, Science.
[24] G. Mills,et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. , 1997, Cancer research.
[25] Thomas L. Madden,et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.
[26] D. Barford,et al. Crystal structure of human protein tyrosine phosphatase 1B. , 1994, Science.
[27] Hong Sun,et al. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[28] K. Mikoshiba,et al. Phospholipid Composition Dependence of Ca-dependent Phospholipid Binding to the C2A Domain of Synaptotagmin IV (*) , 1996, The Journal of Biological Chemistry.
[29] P C Sternweis,et al. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. , 1997, Annual review of biochemistry.
[30] J. Zou,et al. Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.
[31] M. Wigler,et al. PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.
[32] J. Puck,et al. Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II , 1999, Cell.
[33] H. Wu,et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[34] G. Ruvkun,et al. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. , 1998, Molecular cell.
[35] M. Bycroft,et al. Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2* , 1998, The Journal of Biological Chemistry.
[36] H. Hanafusa,et al. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Wigler,et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[38] T. Südhof,et al. C2-domains, Structure and Function of a Universal Ca2+-binding Domain* , 1998, The Journal of Biological Chemistry.
[39] R J Read,et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.
[40] W. Cavenee,et al. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. , 1998, Cancer research.
[41] Carlos Cordon-Cardo,et al. Pten is essential for embryonic development and tumour suppression , 1998, Nature Genetics.
[42] E. Chapman,et al. Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers* , 1998, The Journal of Biological Chemistry.
[43] C. Cordon-Cardo,et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. , 1999, Proceedings of the National Academy of Sciences of the United States of America.