Hyper‐activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury
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J. Catravas | J. Garcia | M. Cherian‐Shaw | R. Rafikov | J. Yuan | Yali Hou | S. Black | Shruti Sharma | A. Desai | Ting Wang | S. Aggarwal | Sanjiv Kumar | Joe G. N. Garcia | Christine M Gross | Xutong Sun | Qing Lu | Ning Qu | S. Noonepalle | E. Zemskov | Sridevi Dasarathy | Vijay Reddy | S. Lee | Qing Lu | M. Cherian-Shaw | S. Dasarathy
[1] R. Rafikov,et al. Endothelial Nitric Oxide Synthase Deficient Mice Are Protected from Lipopolysaccharide Induced Acute Lung Injury , 2015, PloS one.
[2] Yunchao Su,et al. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. , 2014, American journal of respiratory cell and molecular biology.
[3] J. Catravas,et al. Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. , 2014, American journal of respiratory cell and molecular biology.
[4] R. Rafikov,et al. Protein engineering to develop a redox insensitive endothelial nitric oxide synthase☆ , 2014, Redox biology.
[5] J. Catravas,et al. Lipopolysaccharide-induced Lung Injury Involves the Nitration-mediated Activation of RhoA* , 2014, The Journal of Biological Chemistry.
[6] R. Rafikov,et al. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. , 2012, Free radical biology & medicine.
[7] James D. Thomas,et al. Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1. , 2012, Journal of the American College of Cardiology.
[8] Daniel Pardo,et al. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. , 2011, The Journal of endocrinology.
[9] J. Catravas,et al. C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow. , 2011, American journal of respiratory cell and molecular biology.
[10] D. Sedding,et al. Insulin Stabilizes Microvascular Endothelial Barrier Function via Phosphatidylinositol 3-Kinase/Akt-Mediated Rac1 Activation , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[11] R. Damico,et al. cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism. , 2010, American journal of physiology. Lung cellular and molecular physiology.
[12] J. Catravas,et al. Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine. , 2010, Vascular pharmacology.
[13] Yali Hou,et al. Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. , 2010, American journal of physiology. Lung cellular and molecular physiology.
[14] K. Hahn,et al. RhoA GTPase Activation by TLR2 and TLR3 Ligands: Connecting via Src to NF-κB1 , 2009, The Journal of Immunology.
[15] J. Zweier,et al. Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme* , 2008, Journal of Biological Chemistry.
[16] S. Black,et al. Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction. , 2008, American journal of physiology. Cell physiology.
[17] G. Xia,et al. TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia* , 2008, Journal of Biological Chemistry.
[18] G. Hu,et al. Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules. , 2008, Chemico-biological interactions.
[19] E. Park,et al. Src Tyrosine Kinases Mediate Activations of NF-κB and Integrin Signal during Lipopolysaccharide-Induced Acute Lung Injury1 , 2007, The Journal of Immunology.
[20] Glen E. Kellogg,et al. Tyrosine nitration of IκBα : A novel mechanism for NF-κB activation , 2007 .
[21] P. Ward,et al. Role of oxidants in lung injury during sepsis. , 2007, Antioxidants & redox signaling.
[22] S. Hazen,et al. Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma. , 2007, American journal of respiratory cell and molecular biology.
[23] G. Kellogg,et al. Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation. , 2007, Biochemistry.
[24] K. Hirata,et al. Endothelial nitric oxide synthase uncoupling: Is it a physiological mechanism of endothelium-dependent relaxation in cerebral artery? , 2007, Cardiovascular research.
[25] A. Verin,et al. Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells. , 2006, American journal of physiology. Lung cellular and molecular physiology.
[26] J. Leiper,et al. The DDAH-ADMA-NOS Pathway , 2005, Therapeutic drug monitoring.
[27] R. Tuder,et al. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. , 2005, American journal of respiratory and critical care medicine.
[28] W. Seeger,et al. Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[29] R. Böger. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor. , 2004, The Journal of nutrition.
[30] Shakir Ali,et al. Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair , 2004 .
[31] K. Gohil,et al. Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice. , 2004, American journal of physiology. Lung cellular and molecular physiology.
[32] J. Cooke,et al. Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase. , 2003, Atherosclerosis. Supplements.
[33] K. Pritchard,et al. Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of l-Arginine Metabolism to Efficient Nitric Oxide Production* , 2003, Journal of Biological Chemistry.
[34] A. Hingorani,et al. Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. , 2003, Biochemical and biophysical research communications.
[35] R. Böger. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. , 2003, Cardiovascular research.
[36] Ching-mei Hsu,et al. Peroxynitrite is an important mediator in thermal injury–induced lung damage , 2003, Critical care medicine.
[37] Steven M Holland,et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. , 2003, The Journal of clinical investigation.
[38] P. Vallance,et al. Metabolism of Asymmetric Dimethylarginines Is Regulated in the Lung Developmentally and With Pulmonary Hypertension Induced by Hypobaric Hypoxia , 2003, Circulation.
[39] R. Böger. Association of Asymmetric Dimethylarginine and Endothelial Dysfunction , 2003, Clinical chemistry and laboratory medicine.
[40] G. Ronnett,et al. Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide. , 2003, Endothelium : journal of endothelial cell research.
[41] S. Yuan,et al. Src-dependent, neutrophil-mediated vascular hyperpermeability and beta-catenin modification. , 2002, American journal of physiology. Cell physiology.
[42] S. Wedgwood,et al. The Overexpression Catalase Reduces NO‐Mediated Inhibition of Endothelial NO Synthase , 2002, IUBMB life.
[43] S. Yuan. Protein kinase signaling in the modulation of microvascular permeability. , 2002, Vascular pharmacology.
[44] P. Tsao,et al. Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus: Role of Asymmetric Dimethylarginine and Dimethylarginine Dimethylaminohydrolase , 2002, Circulation.
[45] J. Keaney,et al. Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway* , 2002, The Journal of Biological Chemistry.
[46] S. Wedgwood,et al. Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC. , 2001, American journal of physiology. Lung cellular and molecular physiology.
[47] P. L. Becker,et al. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. , 2001, Arteriosclerosis, thrombosis, and vascular biology.
[48] S. Black,et al. Alterations in Endogenous Nitric Oxide Production After Cardiopulmonary Bypass in Lambs With Normal and Increased Pulmonary Blood Flow , 2000, Circulation.
[49] D. Sorescu,et al. Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology , 2000, Arteriosclerosis, thrombosis, and vascular biology.
[50] W. Seeger,et al. The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs. , 2000, American journal of physiology. Lung cellular and molecular physiology.
[51] John G. Collard,et al. Activation of RhoA by Thrombin in Endothelial Hyperpermeability: Role of Rho Kinase and Protein Tyrosine Kinases , 2000, Circulation research.
[52] Y. Hirota,et al. Increased production of nitrotyrosine in lung tissue of rats with radiation-induced acute lung injury. , 2000, American journal of physiology. Lung cellular and molecular physiology.
[53] S. Bode-Böger,et al. Asymmetric Dimethylarginine, Derangements of the Endothelial Nitric Oxide Synthase Pathway, and Cardiovascular Diseases , 2000, Seminars in thrombosis and hemostasis.
[54] P. Tsao,et al. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. , 1999, Circulation.
[55] R. Busse,et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation , 1999, Nature.
[56] J. Cooke,et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. , 1999, Circulation.
[57] E. Jacobs,et al. Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone. , 1999, The Annals of thoracic surgery.
[58] J. Pouysségur,et al. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. , 1998, Molecular biology of the cell.
[59] M. Ishida,et al. c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)* , 1997, The Journal of Biological Chemistry.
[60] S. Cuzzocrea,et al. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. , 1997, The Journal of clinical investigation.
[61] J. Crapo,et al. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock , 1997, British journal of pharmacology.
[62] R. Maunder,et al. Clinical risks for development of the acute respiratory distress syndrome. , 1995, American journal of respiratory and critical care medicine.
[63] M. Lamy,et al. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. , 1994, Journal of critical care.