Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease.
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M. Pawłowski | A. Bojarski | P. Marin | Jean Martínez | G. Satała | P. Popik | E. Colacino | F. Lamaty | A. Partyka | A. Wesołowska | G. Subra | P. Zajdel | Katarzyna Grychowska | X. Bantreil | T. Kos | S. Chaumont-Dubel
[1] A. Bespalov,et al. Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer’s disease , 2015, Expert opinion on investigational drugs.
[2] A. Meneses. Serotonin, neural markers, and memory , 2015, Front. Pharmacol..
[3] D. Galimberti,et al. Idalopirdine as a treatment for Alzheimer’s disease , 2015, Expert opinion on investigational drugs.
[4] J. Bockaert,et al. Serotonin: A New Hope in Alzheimer's Disease? , 2015, ACS chemical neuroscience.
[5] Ben Grayson,et al. Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents , 2015, Behavioural Brain Research.
[6] P. Skolnick,et al. 1-Aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats , 2014, Psychopharmacology.
[7] P. Marin,et al. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism , 2014, Journal of Cell Science.
[8] M. Millan,et al. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. , 2014, Nature chemical biology.
[9] L. Pardo,et al. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. , 2014, Journal of medicinal chemistry.
[10] S. Moro,et al. Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors. , 2013, Journal of medicinal chemistry.
[11] A. A. Ivanenkov. Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity , 2013 .
[12] M. Pawłowski,et al. The pipecolic linker—an acid-labile handle for derivatization of secondary amines on a solid-support. Part 3 , 2013 .
[13] R. Di Santo,et al. Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands. , 2012, Journal of medicinal chemistry.
[14] M. Millan,et al. 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia , 2012, EMBO molecular medicine.
[15] R. Layfield,et al. 5‐HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms , 2012, British journal of pharmacology.
[16] L. Saksida,et al. Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models , 2011, Psychopharmacology.
[17] J. Venhorst,et al. Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats , 2011, Neurobiology of Learning and Memory.
[18] A. Carroll,et al. Aplidiopsamine A, an antiplasmodial alkaloid from the temperate Australian ascidian, Aplidiopsis confluata. , 2010, The Journal of organic chemistry.
[19] Ben Grayson,et al. Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. , 2010, The international journal of neuropsychopharmacology.
[20] B. Roth,et al. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs. , 2010, Current topics in medicinal chemistry.
[21] Jean Martínez,et al. Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives , 2008 .
[22] D. Decamp,et al. Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway* , 2007, Journal of Biological Chemistry.
[23] J. Baik,et al. The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn* , 2007, Journal of Biological Chemistry.
[24] Jean Martínez,et al. 2-Trimethylsilylethanesulfonyl (SES) versus tosyl (Ts) protecting group in the preparation of nitrogen-containing five-membered rings. A novel route for the synthesis of substituted pyrrolines and pyrrolidines. , 2007, The Journal of organic chemistry.
[25] H. Mansell. Pyrrolo(iso)quinoline Derivatives as 5-HT2C Receptor Agonists. , 2006 .
[26] J. Holenz,et al. Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents. , 2006, Drug discovery today.
[27] C. Mathers,et al. Global prevalence of dementia: a Delphi consensus study , 2005, The Lancet.
[28] A. Meneses,et al. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task , 2005, Pharmacology Biochemistry and Behavior.
[29] Leonardo Pardo,et al. A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists. , 2005, Journal of medicinal chemistry.
[30] V. Brown,et al. 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats , 2005, Psychopharmacology.
[31] M. Bös,et al. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. , 2003, Journal of medicinal chemistry.
[32] I. Lucki,et al. Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test , 1998, Psychopharmacology.
[33] L. Lanfumey,et al. Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system , 1997, Brain Research.
[34] Michael Rickels,et al. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants , 1995, Psychopharmacology.
[35] J. Delacour,et al. A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data , 1988, Behavioural Brain Research.
[36] R. Porsolt,et al. Behavioural despair in rats: a new model sensitive to antidepressant treatments. , 1978, European journal of pharmacology.
[37] A. Meneses. Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative , 2014, Reviews in the neurosciences.
[38] F. Dauphin,et al. Selective 5-HT6 Receptor Blockade Improves Spatial Recognition Memory and Reverses Age-Related Deficits in Spatial Recognition Memory in the Mouse , 2009, Neuropsychopharmacology.
[39] K. J. Murphy,et al. The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats , 2004, Neuropsychopharmacology.
[40] B. Beer,et al. A simple and reliable conflict procedure for testing anti-anxiety agents , 2004, Psychopharmacologia.
[41] L. Dawson,et al. The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. , 2001, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
[42] U. Tubingen,et al. of Medicinal , 2022 .